Table of Contents

Commentaries

Commentary:
- Bik K. Tye
From the Cover: Insights into DNA replication from the third domain of life
PNAS 2000 97:2399-2401
- See companion article on page 14783 in issue 26 of volume 96
- See companion article on page 1530 in issue 4 of volume 97
Commentary:
- Paula Tallal
The science of literacy: From the laboratory to the classroom
PNAS 2000 97:2402-2404
- See companion article on page 2952 in issue 6 of volume 97
Commentary:
- Heribert Hirt
Connecting oxidative stress, auxin, and cell cycle regulation through a plant mitogen-activated protein kinase pathway
PNAS 2000 97:2405-2407
- See companion article on page 2940 in issue 6 of volume 97

Physical Sciences

Applied Physical Sciences

Select this article
Physical Sciences - Applied Physical Sciences:
- Daniel T. Chiu,
- Noo Li Jeon,
- Sui Huang,
- Ravi S. Kane,
- Christopher J. Wargo,
- Insung S. Choi,
- Donald E. Ingber,
- and George M. Whitesides
Patterned deposition of cells and proteins onto surfaces by using three-dimensional microfluidic systems
PNAS 2000 97:2408-2413; published ahead of print February 18, 2000
Select this article
Physical Sciences - Applied Physical Sciences:
- Lana G. Kaiser,
- Thomas Meersmann,
- John W. Logan,
- and Alexander Pines
Visualization of gas flow and diffusion in porous media
PNAS 2000 97:2414-2418; published ahead of print March 7, 2000

Chemistry

Select this article
Physical Sciences - Chemistry:
- Dustin J. Maly,
- Ingrid C. Choong,
- and Jonathan A. Ellman
Combinatorial target-guided ligand assembly: Identification of potent subtype-selective c-Src inhibitors
PNAS 2000 97:2419-2424

Geology

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Physical Sciences - Geology:
- Steven A. Benner,
- Kevin G. Devine,
- Lidia N. Matveeva,
- and David H. Powell
From the Cover: The missing organic molecules on Mars
PNAS 2000 97:2425-2430; published ahead of print March 7, 2000

Physics

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Physical Sciences - Physics:
- G. E. Volovik
Monopoles and fractional vortices in chiral superconductors
PNAS 2000 97:2431-2436
Select this article
Physical Sciences - Physics:
- Daniel S. Chemla
- and Jagdeep Shah
Inaugural Article: Ultrafast dynamics of many-body processes and fundamental quantum mechanical phenomena in semiconductors
PNAS 2000 97:2437-2444

Social Sciences

Psychology

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Biological Sciences - Neurobiology - Social Sciences - Psychology:
- Ewan C. McNay,
- Thomas M. Fries,
- and Paul E. Gold
Decreases in rat extracellular hippocampal glucose concentration associated with cognitive demand during a spatial task
PNAS 2000 97:2881-2885; published ahead of print March 7, 2000
Select this article
Social Sciences - Psychology:
- Joel B. Talcott,
- Caroline Witton,
- Maggie F. McLean,
- Peter C. Hansen,
- Adrian Rees,
- Gary G. R. Green,
- and John F. Stein
From the Cover: Dynamic sensory sensitivity and children's word decoding skills
PNAS 2000 97:2952-2957; published ahead of print February 25, 2000
- See commentary article on page 2402 in issue 6 of volume 97

Biological Sciences

Agricultural Sciences

Select this article
Biological Sciences - Agricultural Sciences:
- Guomin Shan,
- Wei Huang,
- Shirley J. Gee,
- Bruce A. Buchholz,
- John S. Vogel,
- and Bruce D. Hammock
Isotope-labeled immunoassays without radiation waste
PNAS 2000 97:2445-2449; published ahead of print March 7, 2000

Applied Biological Sciences

Select this article
Biological Sciences - Applied Biological Sciences:
- Parag Mallick,
- Kenneth E. Goodwill,
- Sorel Fitz-Gibbon,
- Jeffrey H. Miller,
- and David Eisenberg
Selecting protein targets for structural genomics of Pyrobaculum aerophilum : Validating automated fold assignment methods by using binary hypothesis testing
PNAS 2000 97:2450-2455; published ahead of print March 7, 2000

Biophysics

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Biological Sciences - Biophysics:
- Daan Thorn Leeson,
- Feng Gai,
- Hector M. Rodriguez,
- Lydia M. Gregoret,
- and R. Brian Dyer
Protein folding and unfolding on a complex energy landscape
PNAS 2000 97:2527-2532; published ahead of print February 18, 2000
Select this article
Biological Sciences - Biophysics:
- Emi Hirakawa,
- Hideo Higuchi,
- and Yoko Y. Toyoshima
Processive movement of single 22S dynein molecules occurs only at low ATP concentrations
PNAS 2000 97:2533-2537; published ahead of print March 7, 2000
Select this article
Biological Sciences - Biophysics:
- Judith M. Nocek,
- Kai Huang,
- and Brian M. Hoffman
Extension of transverse relaxation-optimized spectroscopy techniques to allosteric proteins: CO- and paramagnetic fluoromet-hemoglobin [β( 15 N-valine)]
PNAS 2000 97:2538-2543
Select this article
Biological Sciences - Biophysics:
- D. K. Klimov
- and D. Thirumalai
Mechanisms and kinetics of β-hairpin formation
PNAS 2000 97:2544-2549
Select this article
Biological Sciences - Biophysics:
- Chao Zhang
- and Sung-Hou Kim
Environment-dependent residue contact energies for proteins
PNAS 2000 97:2550-2555; published ahead of print March 7, 2000
Select this article
Biological Sciences - Biophysics:
- Feliksas F. Bukauskas,
- Karen Jordan,
- Angele Bukauskiene,
- Michael V. L. Bennett,
- Paul D. Lampe,
- Dale W. Laird,
- and Vytas K. Verselis
Clustering of connexin 43–enhanced green fluorescent protein gap junction channels and functional coupling in living cells
PNAS 2000 97:2556-2561; published ahead of print March 7, 2000
Select this article
Biological Sciences - Biophysics:
- Peer R. E. Mittl,
- Christine Deillon,
- David Sargent,
- Niankun Liu,
- Stephan Klauser,
- Richard M. Thomas,
- Bernd Gutte,
- and Markus G. Grütter
The retro -GCN4 leucine zipper sequence forms a stable three-dimensional structure
PNAS 2000 97:2562-2566

Cell Biology

Select this article
Biological Sciences - Cell Biology:
- Ryoichi Yamaji,
- Ronald Adamik,
- Kazuyo Takeda,
- Akira Togawa,
- Gustavo Pacheco-Rodriguez,
- Victor J. Ferrans,
- Joel Moss,
- and Martha Vaughan
Identification and localization of two brefeldin A-inhibited guanine nucleotide-exchange proteins for ADP-ribosylation factors in a macromolecular complex
PNAS 2000 97:2567-2572
Select this article
Biological Sciences - Cell Biology:
- Michael L. Gagnon,
- Diane R. Bielenberg,
- Ze'ev Gechtman,
- Hua-Quan Miao,
- Seiji Takashima,
- Shay Soker,
- and Michael Klagsbrun
Identification of a natural soluble neuropilin-1 that binds vascular endothelial growth factor: In vivo expression and antitumor activity
PNAS 2000 97:2573-2578; published ahead of print February 25, 2000
Select this article
Biological Sciences - Cell Biology:
- Per U. Christensen,
- Nicola J. Bentley,
- Rui G. Martinho,
- Olaf Nielsen,
- and Antony M. Carr
Mik1 levels accumulate in S phase and may mediate an intrinsic link between S phase and mitosis
PNAS 2000 97:2579-2584
Select this article
Biological Sciences - Cell Biology:
- Naoki Shinohara,
- Taku Demura,
- and Hiroo Fukuda
Isolation of a vascular cell wall-specific monoclonal antibody recognizing a cell polarity by using a phage display subtraction method
PNAS 2000 97:2585-2590; published ahead of print March 7, 2000
Select this article
Biological Sciences - Cell Biology:
- Canan G. Nebigil,
- Jean-Marie Launay,
- Pierre Hickel,
- Claire Tournois,
- and Luc Maroteaux
5-Hydroxytryptamine 2B receptor regulates cell-cycle progression: Cross-talk with tyrosine kinase pathways
PNAS 2000 97:2591-2596; published ahead of print February 25, 2000
Select this article
Biological Sciences - Cell Biology:
- Hong Zhang,
- Qunli Xu,
- Stanislaw Krajewski,
- Maryla Krajewska,
- Zhihua Xie,
- Sally Fuess,
- Shinichi Kitada,
- Krzysztof Pawłowski,
- Adam Godzik,
- and John C. Reed
BAR: An apoptosis regulator at the intersection of caspases and Bcl-2 family proteins
PNAS 2000 97:2597-2602
Select this article
Biological Sciences - Cell Biology:
- Kung Meng,
- A. Rodríguez-Peña,
- Todor Dimitrov,
- Wen Chen,
- Moshe Yamin,
- Masaharu Noda,
- and Thomas F. Deuel
Pleiotrophin signals increased tyrosine phosphorylation of β-catenin through inactivation of the intrinsic catalytic activity of the receptor-type protein tyrosine phosphatase β/ζ
PNAS 2000 97:2603-2608; published ahead of print March 7, 2000

Developmental Biology

Select this article
Biological Sciences - Developmental Biology:
- A. Baonza
- and A. Garcia-Bellido
Notch signaling directly controls cell proliferation in the Drosophila wing disc
PNAS 2000 97:2609-2614; published ahead of print March 7, 2000
Select this article
Biological Sciences - Developmental Biology:
- Elizabeth M. Callery
- and Richard P. Elinson
From the Cover: Thyroid hormone-dependent metamorphosis in a direct developing frog
PNAS 2000 97:2615-2620; published ahead of print March 7, 2000
Select this article
Biological Sciences - Developmental Biology:
- Ruth T. Yu,
- Ming-Yi Chiang,
- Teruyo Tanabe,
- Mime Kobayashi,
- Kunio Yasuda,
- Ronald M. Evans,
- and Kazuhiko Umesono
The orphan nuclear receptor Tlx regulates Pax2 and is essential for vision
PNAS 2000 97:2621-2625; published ahead of print March 7, 2000
Select this article
Biological Sciences - Developmental Biology:
- S. Paul Oh,
- Tsugio Seki,
- Kendrick A. Goss,
- Takeshi Imamura,
- Youngsuk Yi,
- Patricia K. Donahoe,
- Li Li,
- Kohei Miyazono,
- Peter ten Dijke,
- Seongjin Kim,
- and En Li
Activin receptor-like kinase 1 modulates transforming growth factor-β1 signaling in the regulation of angiogenesis
PNAS 2000 97:2626-2631

Ecology

Select this article
Biological Sciences - Ecology:
- Thomas Eisner
- and Maria Eisner
Defensive use of a fecal thatch by a beetle larva ( Hemisphaerota cyanea )
PNAS 2000 97:2632-2636; published ahead of print February 18, 2000
Select this article
Biological Sciences - Ecology:
- Reuven Dukas
- and Elizabeth A. Bernays
Learning improves growth rate in grasshoppers
PNAS 2000 97:2637-2640; published ahead of print March 7, 2000

Evolution

Select this article
Biological Sciences - Evolution:
- Jukka Jernvall
Linking development with generation of novelty in mammalian teeth
PNAS 2000 97:2641-2645

FROM THE COVER

From the Cover: Insights into DNA replication from the third domain of life

The science of literacy: From the laboratory to the classroom

Connecting oxidative stress, auxin, and cell cycle regulation through a plant mitogen-activated protein kinase pathway

Patterned deposition of cells and proteins onto surfaces by using three-dimensional microfluidic systems

Visualization of gas flow and diffusion in porous media

Combinatorial target-guided ligand assembly: Identification of potent subtype-selective c-Src inhibitors

From the Cover: The missing organic molecules on Mars

Monopoles and fractional vortices in chiral superconductors

Inaugural Article: Ultrafast dynamics of many-body processes and fundamental quantum mechanical phenomena in semiconductors

Decreases in rat extracellular hippocampal glucose concentration associated with cognitive demand during a spatial task

From the Cover: Dynamic sensory sensitivity and children's word decoding skills

Isotope-labeled immunoassays without radiation waste

Selecting protein targets for structural genomics of Pyrobaculum aerophilum : Validating automated fold assignment methods by using binary hypothesis testing

Different functional domains of TAF II 250 modulate expression of distinct subsets of mammalian genes

Ribosomal subunit kinase-2 is required for growth factor-stimulated transcription of the c- Fos gene

Erythroid Krüppel-like factor is recruited to the CACCC box in the β-globin promoter but not to the CACCC box in the γ-globin promoter: The role of the neighboring promoter elements

Yeast ribonucleotide reductase has a heterodimeric iron-radical-containing subunit

On the interpretation of quantitative structure–function activity relationship data for lactate oxidase

Biosynthesis of terpenoids: YgbB protein converts 4-diphosphocytidyl-2C-methyl- d -erythritol 2-phosphate to 2C-methyl- d -erythritol 2,4-cyclodiphosphate

The interaction of nitric oxide (NO) with the yeast transcription factor Ace1: A model system for NO-protein thiol interactions with implications to metal metabolism

Physical association of ubiquitin ligases and the 26S proteasome

Zinc transfer potentials of the α- and β-clusters of metallothionein are affected by domain interactions in the whole molecule

The EntF and EntE adenylation domains of Escherichia coli enterobactin synthetase: Sequestration and selectivity in acyl-AMP transfers to thiolation domain cosubstrates

Evidence for a requirement for ATP hydrolysis at two distinct steps during a single turnover of the catalytic cycle of human P-glycoprotein

Mammalian thioredoxin reductase: Oxidation of the C-terminal cysteine/selenocysteine active site forms a thioselenide, and replacement of selenium with sulfur markedly reduces catalytic activity

Protein folding and unfolding on a complex energy landscape

Processive movement of single 22S dynein molecules occurs only at low ATP concentrations

Extension of transverse relaxation-optimized spectroscopy techniques to allosteric proteins: CO- and paramagnetic fluoromet-hemoglobin [β( 15 N-valine)]

Mechanisms and kinetics of β-hairpin formation

Environment-dependent residue contact energies for proteins

Clustering of connexin 43–enhanced green fluorescent protein gap junction channels and functional coupling in living cells

The retro -GCN4 leucine zipper sequence forms a stable three-dimensional structure

Identification and localization of two brefeldin A-inhibited guanine nucleotide-exchange proteins for ADP-ribosylation factors in a macromolecular complex

Identification of a natural soluble neuropilin-1 that binds vascular endothelial growth factor: In vivo expression and antitumor activity

Mik1 levels accumulate in S phase and may mediate an intrinsic link between S phase and mitosis

Isolation of a vascular cell wall-specific monoclonal antibody recognizing a cell polarity by using a phage display subtraction method

5-Hydroxytryptamine 2B receptor regulates cell-cycle progression: Cross-talk with tyrosine kinase pathways

BAR: An apoptosis regulator at the intersection of caspases and Bcl-2 family proteins

Pleiotrophin signals increased tyrosine phosphorylation of β-catenin through inactivation of the intrinsic catalytic activity of the receptor-type protein tyrosine phosphatase β/ζ

Notch signaling directly controls cell proliferation in the Drosophila wing disc

From the Cover: Thyroid hormone-dependent metamorphosis in a direct developing frog

The orphan nuclear receptor Tlx regulates Pax2 and is essential for vision

Activin receptor-like kinase 1 modulates transforming growth factor-β1 signaling in the regulation of angiogenesis

Defensive use of a fecal thatch by a beetle larva ( Hemisphaerota cyanea )

Learning improves growth rate in grasshoppers

Linking development with generation of novelty in mammalian teeth