Table of Contents

Commentaries

Commentary:
- John R. Huguenard
Reliability of axonal propagation: The spike doesn't stop here
PNAS 2000 97:9349-9350
- See companion article on page 9724 in issue 17 of volume 97
Commentary:
- David M. J. Lilley
- and Malcolm F. White
Resolving the relationships of resolving enzymes
PNAS 2000 97:9351-9353
- See companion article on page 8926 in issue 16 of volume 97
Commentary:
- Ioannis V. Yannas
Synthesis of organs: In vitro or in vivo?
PNAS 2000 97:9354-9356; published online before print August 8, 2000
- See companion article on page 9191 in issue 16 of volume 97
Commentary:
- Toshio Yanagida
- and Atsuko H. Iwane
A large step for myosin
PNAS 2000 97:9357-9359
- See companion article on page 9482 in issue 17 of volume 97
Commentary:
- Shan Ping Yu
- and Dennis W. Choi
Ions, cell volume, and apoptosis
PNAS 2000 97:9360-9362
- See companion article on page 9487 in issue 17 of volume 97
Commentary:
- Stephen E. Straus
Immunoactive cannabinoids: Therapeutic prospects for marijuana constituents
PNAS 2000 97:9363-9364; published online before print August 8, 2000
- See companion article on page 9561 in issue 17 of volume 97
Commentary:
- Charles J. Goodnight
Heritability at the ecosystem level
PNAS 2000 97:9365-9366
- See companion article on page 9110 in issue 16 of volume 97

Physical Sciences

Chemistry

Select this article
Physical Sciences - Chemistry:
- Daniel A. Erlanson,
- Andrew C. Braisted,
- Darren R. Raphael,
- Mike Randal,
- Robert M. Stroud,
- Eric M. Gordon,
- and James A. Wells
Site-directed ligand discovery
PNAS 2000 97:9367-9372
Select this article
Physical Sciences - Chemistry:
- William Shakespeare,
- Michael Yang,
- Regine Bohacek,
- Franklin Cerasoli,
- Karin Stebbins,
- Raji Sundaramoorthi,
- Mihai Azimioara,
- Chi Vu,
- Selvi Pradeepan,
- Chester Metcalf III,
- Chad Haraldson,
- Taylor Merry,
- David Dalgarno,
- Surinder Narula,
- Marcos Hatada,
- Xiaode Lu,
- Marie Rose van Schravendijk,
- Susan Adams,
- Shelia Violette,
- Jeremy Smith,
- Wei Guan,
- Catherine Bartlett,
- Jay Herson,
- John Iuliucci,
- Manfred Weigele,
- and Tomi Sawyer
Structure-based design of an osteoclast-selective, nonpeptide Src homology 2 inhibitor with in vivo antiresorptive activity
PNAS 2000 97:9373-9378
Select this article
Physical Sciences - Chemistry - Biological Sciences - Biophysics:
- Remedios González-Luque,
- Marco Garavelli,
- Fernando Bernardi,
- Manuela Merchán,
- Michael A. Robb,
- and Massimo Olivucci
Computational evidence in favor of a two-state, two-mode model of the retinal chromophore photoisomerization
PNAS 2000 97:9379-9384

Engineering

Select this article
Physical Sciences - Engineering:
- Kurt Lin,
- Pin-Pin Hsu,
- Benjamin P. Chen,
- Suli Yuan,
- Shunichi Usami,
- John Y.-J. Shyy,
- Yi-Shuan Li,
- and Shu Chien
Molecular mechanism of endothelial growth arrest by laminar shear stress
PNAS 2000 97:9385-9389; published online before print August 1, 2000

Biological Sciences

Applied Biological Sciences

Select this article
Biological Sciences - Applied Biological Sciences:
- Steven P. Gygi,
- Garry L. Corthals,
- Yanni Zhang,
- Yvan Rochon,
- and Ruedi Aebersold
Evaluation of two-dimensional gel electrophoresis-based proteome analysis technology
PNAS 2000 97:9390-9395; published online before print August 1, 2000

Biophysics

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Physical Sciences - Chemistry - Biological Sciences - Biophysics:
- Remedios González-Luque,
- Marco Garavelli,
- Fernando Bernardi,
- Manuela Merchán,
- Michael A. Robb,
- and Massimo Olivucci
Computational evidence in favor of a two-state, two-mode model of the retinal chromophore photoisomerization
PNAS 2000 97:9379-9384
Select this article
Biological Sciences - Biophysics:
- Thilo D. Lacoste,
- Xavier Michalet,
- Fabien Pinaud,
- Daniel S. Chemla,
- A. Paul Alivisatos,
- and Shimon Weiss
Ultrahigh-resolution multicolor colocalization of single fluorescent probes
PNAS 2000 97:9461-9466; published online before print August 8, 2000
Select this article
Biological Sciences - Biophysics:
- D. A. Beysens,
- G. Forgacs,
- and J. A. Glazier
Cell sorting is analogous to phase ordering in fluids
PNAS 2000 97:9467-9471
Select this article
Biological Sciences - Biophysics:
- Seth M. Rubin,
- Megan M. Spence,
- Boyd M. Goodson,
- David E. Wemmer,
- and Alexander Pines
Evidence of nonspecific surface interactions between laser-polarized xenon and myoglobin in solution
PNAS 2000 97:9472-9475; published online before print August 8, 2000
Select this article
Biological Sciences - Biophysics:
- Matthew Bennett,
- Alexander Krah,
- Frank Wien,
- Elspeth Garman,
- Robert Mckenna,
- Mark Sanderson,
- and Stephen Neidle
A DNA–porphyrin minor-groove complex at atomic resolution: The structural consequences of porphyrin ruffling
PNAS 2000 97:9476-9481; published online before print August 1, 2000
Select this article
Biological Sciences - Biophysics:
- Matthias Rief,
- Ronald S. Rock,
- Amit D. Mehta,
- Mark S. Mooseker,
- Richard E. Cheney,
- and James A. Spudich
Myosin-V stepping kinetics: A molecular model for processivity
PNAS 2000 97:9482-9486
- See commentary article on page 9357 in issue 17 of volume 97

Cell Biology

Select this article
Biological Sciences - Cell Biology:
- Emi Maeno,
- Yasuki Ishizaki,
- Toku Kanaseki,
- Akihiro Hazama,
- and Yasunobu Okada
From the Cover: Normotonic cell shrinkage because of disordered volume regulation is an early prerequisite to apoptosis
PNAS 2000 97:9487-9492; published online before print July 18, 2000
- See commentary article on page 9360 in issue 17 of volume 97
Select this article
Biological Sciences - Cell Biology:
- Robin L. Kolnicki
Kinetochore reproduction in animal evolution: Cell biological explanation of karyotypic fission theory
PNAS 2000 97:9493-9497
- See commentary article on page 9821 in issue 18 of volume 97
Select this article
Biological Sciences - Cell Biology:
- Gisela F. Claassen
- and Stephen R. Hann
A role for transcriptional repression of p21^CIP1 by c-Myc in overcoming transforming growth factor β-induced cell-cycle arrest
PNAS 2000 97:9498-9503; published online before print August 1, 2000
Select this article
Biological Sciences - Cell Biology:
- Michael W. Berns,
- Zifu Wang,
- Andrew Dunn,
- Vincent Wallace,
- and Vasan Venugopalan
Gene inactivation by multiphoton-targeted photochemistry
PNAS 2000 97:9504-9507

Developmental Biology

Select this article
Biological Sciences - Developmental Biology:
- Canan G. Nebigil,
- Doo-Sup Choi,
- Andrée Dierich,
- Pierre Hickel,
- Marianne Le Meur,
- Nadia Messaddeq,
- Jean-Marie Launay,
- and Luc Maroteaux
Serotonin 2B receptor is required for heart development
PNAS 2000 97:9508-9513
Select this article
Biological Sciences - Developmental Biology:
- R. Andrew Cameron,
- Gregory Mahairas,
- Jonathan P. Rast,
- Pedro Martinez,
- Ted R. Biondi,
- Steven Swartzell,
- James C. Wallace,
- Albert J. Poustka,
- Brian T. Livingston,
- Gregory A. Wray,
- Charles A. Ettensohn,
- Hans Lehrach,
- Roy J. Britten,
- Eric H. Davidson,
- and Leroy Hood
A sea urchin genome project: Sequence scan, virtual map, and additional resources
PNAS 2000 97:9514-9518; published online before print August 1, 2000
Select this article
Biological Sciences - Developmental Biology:
- Tommy Hock,
- Tracy Cottrill,
- John Keegan,
- and Dan Garza
The E23 early gene of Drosophila encodes an ecdysone-inducible ATP-binding cassette transporter capable of repressing ecdysone-mediated gene activation
PNAS 2000 97:9519-9524; published online before print August 8, 2000
Select this article
Biological Sciences - Developmental Biology:
- JianRong Lu,
- Priscilla Chang,
- James A. Richardson,
- Lin Gan,
- Hartmut Weiler,
- and Eric N. Olson
Inaugural Article: The basic helix–loop–helix transcription factor capsulin controls spleen organogenesis
PNAS 2000 97:9525-9530

Genetics

Select this article
Biological Sciences - Genetics:
- Karin Thevissen,
- Bruno P. A. Cammue,
- Katleen Lemaire,
- Joris Winderickx,
- Robert C. Dickson,
- Robert L. Lester,
- Kathelijne K. A. Ferket,
- Frederic Van Even,
- Annabel H. A. Parret,
- and Willem F. Broekaert
A gene encoding a sphingolipid biosynthesis enzyme determines the sensitivity of Saccharomyces cerevisiae to an antifungal plant defensin from dahlia (Dahlia merckii)
PNAS 2000 97:9531-9536; published online before print August 8, 2000
Select this article
Biological Sciences - Genetics:
- Alastair S. H. Goldman
- and Michael Lichten
Restriction of ectopic recombination by interhomolog interactions during Saccharomyces cerevisiae meiosis
PNAS 2000 97:9537-9542
Select this article
Biological Sciences - Genetics:
- R.-M. Hu,
- Z.-G. Han,
- H.-D. Song,
- Y.-D. Peng,
- Q.-H. Huang,
- S.-X. Ren,
- Y.-J. Gu,
- C.-H. Huang,
- Y.-B. Li,
- C.-L. Jiang,
- G. Fu,
- Q.-H. Zhang,
- B.-W. Gu,
- M. Dai,
- Y.-F. Mao,
- G.-F. Gao,
- R. Rong,
- M. Ye,
- J. Zhou,
- S.-H. Xu,
- J. Gu,
- J.-X. Shi,
- W.-R. Jin,
- C.-K. Zhang,
- T.-M. Wu,
- G.-Y. Huang,
- Z. Chen,
- M.-D. Chen,
- and J.-L. Chen
Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning
PNAS 2000 97:9543-9548; published online before print August 8, 2000
Select this article
Biological Sciences - Genetics:
- Karin Jurkat-Rott,
- Nenad Mitrovic,
- Chao Hang,
- Alexei Kouzmenkine,
- Paul Iaizzo,
- Jürgen Herzog,
- Holger Lerche,
- Sophie Nicole,
- Jose Vale-Santos,
- Dominique Chauveau,
- Bertrand Fontaine,
- and Frank Lehmann-Horn
Voltage-sensor sodium channel mutations cause hypokalemic periodic paralysis type 2 by enhanced inactivation and reduced current
PNAS 2000 97:9549-9554
- See commentary article on page 9832 in issue 18 of volume 97

Immunology

Select this article
Biological Sciences - Immunology:
- Judith A. Shizuru,
- Irving L. Weissman,
- Rachel Kernoff,
- Marilyn Masek,
- and Yolanda C. Scheffold
Purified hematopoietic stem cell grafts induce tolerance to alloantigens and can mediate positive and negative T cell selection
PNAS 2000 97:9555-9560; published online before print August 1, 2000
Select this article
Biological Sciences - Immunology:
- A. M. Malfait,
- R. Gallily,
- P. F. Sumariwalla,
- A. S. Malik,
- E. Andreakos,
- R. Mechoulam,
- and M. Feldmann
From the Cover: The nonpsychoactive cannabis constituent cannabidiol is an oral anti-arthritic therapeutic in murine collagen-induced arthritis
PNAS 2000 97:9561-9566; published online before print August 1, 2000
- See commentary article on page 9363 in issue 17 of volume 97
Select this article
Biological Sciences - Immunology:
- Lei Ling
- and David V. Goeddel
T6BP, a TRAF6-interacting protein involved in IL-1 signaling
PNAS 2000 97:9567-

FROM THE COVER

Reliability of axonal propagation: The spike doesn't stop here

Resolving the relationships of resolving enzymes

Synthesis of organs: In vitro or in vivo?

A large step for myosin

Ions, cell volume, and apoptosis

Immunoactive cannabinoids: Therapeutic prospects for marijuana constituents

Heritability at the ecosystem level

Site-directed ligand discovery

Structure-based design of an osteoclast-selective, nonpeptide Src homology 2 inhibitor with in vivo antiresorptive activity

Computational evidence in favor of a two-state, two-mode model of the retinal chromophore photoisomerization

Molecular mechanism of endothelial growth arrest by laminar shear stress

Evaluation of two-dimensional gel electrophoresis-based proteome analysis technology

A retroviral RNA kissing complex containing only two G⋅C base pairs

A Ypt/Rab effector complex containing the Sec1 homolog Vps33p is required for homotypic vacuole fusion

Redesign of substrate-selectivity determining modules of glutathione transferase A1–1 installs high catalytic efficiency with toxic alkenal products of lipid peroxidation

The crystal structure of d-lactate dehydrogenase, a peripheral membrane respiratory enzyme

Analysis of topoisomerase function in bacterial replication fork movement: Use of DNA microarrays

Autocatalytic proteolysis of the transcription factor-coactivator C1 (HCF): A potential role for proteolytic regulation of coactivator function

A distinctive role for the Yersinia protein kinase: Actin binding, kinase activation, and cytoskeleton disruption

TARP: A nuclear protein expressed in prostate and breast cancer cells derived from an alternate reading frame of the T cell receptor γ chain locus

Intramolecular control of transcriptional activity by the NK2-specific domain in NK-2 homeodomain proteins

A Δ9 desaturase gene with a different substrate specificity is responsible for the cuticular diene hydrocarbon polymorphism in Drosophila melanogaster

Inversion of stereospecificity of vanillyl-alcohol oxidase

Computational evidence in favor of a two-state, two-mode model of the retinal chromophore photoisomerization

Ultrahigh-resolution multicolor colocalization of single fluorescent probes

Cell sorting is analogous to phase ordering in fluids

Evidence of nonspecific surface interactions between laser-polarized xenon and myoglobin in solution

A DNA–porphyrin minor-groove complex at atomic resolution: The structural consequences of porphyrin ruffling

Myosin-V stepping kinetics: A molecular model for processivity

From the Cover: Normotonic cell shrinkage because of disordered volume regulation is an early prerequisite to apoptosis

Kinetochore reproduction in animal evolution: Cell biological explanation of karyotypic fission theory

A role for transcriptional repression of p21CIP1 by c-Myc in overcoming transforming growth factor β-induced cell-cycle arrest

Gene inactivation by multiphoton-targeted photochemistry

Serotonin 2B receptor is required for heart development

A sea urchin genome project: Sequence scan, virtual map, and additional resources

The E23 early gene of Drosophila encodes an ecdysone-inducible ATP-binding cassette transporter capable of repressing ecdysone-mediated gene activation

Inaugural Article: The basic helix–loop–helix transcription factor capsulin controls spleen organogenesis

A gene encoding a sphingolipid biosynthesis enzyme determines the sensitivity of Saccharomyces cerevisiae to an antifungal plant defensin from dahlia (Dahlia merckii)

Restriction of ectopic recombination by interhomolog interactions during Saccharomyces cerevisiae meiosis

Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning

Voltage-sensor sodium channel mutations cause hypokalemic periodic paralysis type 2 by enhanced inactivation and reduced current

Purified hematopoietic stem cell grafts induce tolerance to alloantigens and can mediate positive and negative T cell selection

From the Cover: The nonpsychoactive cannabis constituent cannabidiol is an oral anti-arthritic therapeutic in murine collagen-induced arthritis

T6BP, a TRAF6-interacting protein involved in IL-1 signaling

A role for transcriptional repression of p21^CIP1 by c-Myc in overcoming transforming growth factor β-induced cell-cycle arrest