Table of Contents

• Jianming Cao,
• Hyotcherl Ihee,
• and Ahmed H. Zewail

Ultrafast electron diffraction and direct observation of transient structures in a chemical reaction

• Athar Ansari
• and Marc R. Gartenberg

Persistence of an alternate chromatin structure at silenced loci in vitro

• David O’Neill,
• John Yang,
• Hediye Erdjument-Bromage,
• Katherine Bornschlegel,
• Paul Tempst,
• and Arthur Bank

Tissue-specific and developmental stage-specific DNA binding by a mammalian SWI/SNF complex associated with human fetal-to-adult globin gene switching

• Mark M. Burcin,
• Gudrun Schiedner,
• Stefan Kochanek,
• Sophia Y. Tsai,
• and Bert W. O’Malley

Adenovirus-mediated regulable target gene expression in vivo

• Jennifer N. Cha,
• Katsuhiko Shimizu,
• Yan Zhou,
• Sean C. Christiansen,
• Bradley F. Chmelka,
• Galen D. Stucky,
• and Daniel E. Morse

Silicatein filaments and subunits from a marine sponge direct the polymerization of silica and silicones in vitro

• Raymond R. Samaha,
• Simpson Joseph,
• Bonnie O’Brien,
• Thomas W. O’Brien,
• and Harry F. Noller

Site-directed hydroxyl radical probing of 30S ribosomal subunits by using Fe(II) tethered to an interruption in the 16S rRNA chain

• Yong Ma,
• Kazuhide Uemura,
• Shogo Oka,
• Yasunori Kozutsumi,
• Nobuko Kawasaki,
• and Toshisuke Kawasaki

Antitumor activity of mannan-binding protein in vivo as revealed by a virus expression system: Mannan-binding proteindependent cell-mediated cytotoxicity

• Darius Balciunas,
• Cecilia Gälman,
• Hans Ronne,
• and Stefan Björklund

The Med1 subunit of the yeast mediator complex is involved in both transcriptional activation and repression

• Tianlin Ma,
• Nianxiang Zou,
• Biing Yuan Lin,
• Louise T. Chow,
• and J. Wade Harper

Interaction between cyclin-dependent kinases and human papillomavirus replication-initiation protein E1 is required for efficient viral replication

• Rong Xu,
• Brenda Ayers,
• David Cowburn,
• and Tom W. Muir

Chemical ligation of folded recombinant proteins: Segmental isotopic labeling of domains for NMR studies

• Hanna Brzeska,
• Rachel Young,
• Ulla Knaus,
• and Edward D. Korn

Myosin I heavy chain kinase: Cloning of the full-length gene and acidic lipid-dependent activation by Rac and Cdc42

• Simon C. Lovell,
• J. Michael Word,
• Jane S. Richardson,
• and David C. Richardson

Asparagine and glutamine rotamers: B -factor cutoff and correction of amide flips yield distinct clustering

• Dapeng Zhou,
• André Dinter,
• Ricardo Gutiérrez Gallego,
• Johannis P. Kamerling,
• Johannes F. G. Vliegenthart,
• Eric G. Berger,
• and Thierry Hennet

A β-1,3- N -acetylglucosaminyltransferase with poly- N -acetyllactosamine synthase activity is structurally related to β-1,3-galactosyltransferases

• Chunfa Huang,
• Joseph A. Duncan,
• Alfred G. Gilman,
• and Susanne M. Mumby

Persistent membrane association of activated and depalmitoylated G protein α subunits

• Michael Ibba,
• Heather C. Losey,
• Yutaka Kawarabayasi,
• Hisasi Kikuchi,
• Shipra Bunjun,
• and Dieter Söll

Substrate recognition by class I lysyl-tRNA synthetases: A molecular basis for gene displacement

• Byung Joon Hwang,
• James M. Ford,
• Philip C. Hanawalt,
• and Gilbert Chu

Expression of the p48 xeroderma pigmentosum gene is p53-dependent and is involved in global genomic repair

• Christophe Béraud,
• William J. Henzel,
• and Patrick A. Baeuerle

Involvement of regulatory and catalytic subunits of phosphoinositide 3-kinase in NF-κB activation

• Tohru Tezuka,
• Hisashi Umemori,
• Tetsu Akiyama,
• Shigetada Nakanishi,
• and Tadashi Yamamoto

PSD-95 promotes Fyn-mediated tyrosine phosphorylation of the N -methyl- d -aspartate receptor subunit NR2A

• Michael Weinreich,
• Chun Liang,
• and Bruce Stillman

The Cdc6p nucleotide-binding motif is required for loading Mcm proteins onto chromatin

• Lin Huang,
• Keiko Kumura Ishii,
• Harmon Zuccola,
• Amy M. Gehring,
• Charles B. C. Hwang,
• James Hogle,
• and Donald M. Coen

The enzymological basis for resistance of herpesvirus DNA polymerase mutants to acyclovir: Relationship to the structure of α-like DNA polymerases

• Sergio Gurrieri,
• Steven B. Smith,
• and Carlos Bustamante

Trapping of megabase-sized DNA molecules during agarose gel electrophoresis

• Barden Chan,
• Kristin Weidemaier,
• Wai-Tak Yip,
• Paul F. Barbara,
• and Karin Musier-Forsyth

Intra-tRNA distance measurements for nucleocapsid proteindependent tRNA unwinding during priming of HIV reverse transcription

• Matthew Walker,
• Xue-Zhong Zhang,
• Wei Jiang,
• John Trinick,
• and Howard D. White

Observation of transient disorder during myosin subfragment-1 binding to actin by stopped-flow fluorescence and millisecond time resolution electron cryomicroscopy: Evidence that the start of the crossbridge power stroke in muscle has variable geometry

• G. Sagvolden,
• I. Giaever,
• E. O. Pettersen,
• and J. Feder

Cell adhesion force microscopy

• Yawen Bai

Kinetic evidence for an on-pathway intermediate in the folding of cytochrome c

• Alexander Pertsemlidis,
• Alan K. Soper,
• Jon M. Sorenson,
• and Teresa Head-Gordon

Evidence for microscopic, long-range hydration forces for a hydrophobic amino acid

• Markus Eilers,
• Philip J. Reeves,
• Weiwen Ying,
• H. Gobind Khorana,
• and Steven O. Smith

Magic angle spinning NMR of the protonated retinylidene Schiff base nitrogen in rhodopsin: Expression of 15 N-lysine- and 13 C-glycine-labeled opsin in a stable cell line

• Sutapa Mukherjee,
• Krzysztof Palczewski,
• Vsevolod Gurevich,
• Jeffrey L. Benovic,
• J. Paul Banga,
• and Mary Hunzicker-Dunn

A direct role for arrestins in desensitization of the luteinizing hormone/choriogonadotropin receptor in porcine ovarian follicular membranes

• Taroh Iiri,
• Sean M. Bell,
• Thomas J. Baranski,
• Toshiro Fujita,
• and Henry R. Bourne

A G sα mutant designed to inhibit receptor signaling through G s

• Larry Pederson,
• Matthew Kremer,
• Jeffrey Judd,
• David Pascoe,
• Thomas C. Spelsberg,
• B. Lawrence Riggs,
• and Merry Jo Oursler

Androgens regulate bone resorption activity of isolated osteoclasts in vitro

• Kazumasa Morita,
• Mikio Furuse,
• Kazushi Fujimoto,
• and Shoichiro Tsukita

Claudin multigene family encoding four-transmembrane domain protein components of tight junction strands

• Chang-rung Chen,
• Ying-chun Li,
• Jing Chen,
• Ming-chin Hou,
• Piyi Papadaki,
• and Eric C. Chang

Moe1, a conserved protein in Schizosaccharomyces pombe , interacts with a Ras effector, Scd1, to affect proper spindle formation

• Urte Gayko,
• Vaughn Cleghon,
• Terry Copeland,
• Deborah K. Morrison,
• and Norbert Perrimon

Synergistic activities of multiple phosphotyrosine residues mediate full signaling from the Drosophila Torso receptor tyrosine kinase

• Elisabeth Verpy,
• Michel Leibovici,
• and Christine Petit

Characterization of otoconin-95, the major protein of murine otoconia, provides insights into the formation of these inner ear biominerals

• Feng Chen
• and Mario R. Capecchi

Paralogous mouse Hox genes, Hoxa9, Hoxb9, and Hoxd9, function together to control development of the mammary gland in response to pregnancy

• Olivia Wendling,
• Pierre Chambon,
• and Manuel Mark

Retinoid X receptors are essential for early mouse development and placentogenesis

• Jianrong Lu,
• Robert Webb,
• James A. Richardson,
• and Eric N. Olson

MyoR: A muscle-restricted basic helix–loop–helix transcription factor that antagonizes the actions of MyoD

• P. Callaerts,
• A. M. Munoz-Marmol,
• S. Glardon,
• E. Castillo,
• H. Sun,
• W.-H. Li,
• W. J. Gehring,
• and E. Salo

Isolation and expression of a Pax-6 gene in the regenerating and intact Planarian Dugesia(G)tigrina

• Bernd Hauck,
• Walter J. Gehring,
• and Uwe Walldorf

Functional analysis of an eye specific enhancer of the eyeless gene in Drosophila

• R. G. Nager,
• P. Monaghan,
• R. Griffiths,
• D. C. Houston,
• and R. Dawson

Experimental demonstration that offspring sex ratio varies with maternal condition

• James D. Fry,
• Peter D. Keightley,
• Stefanie L. Heinsohn,
• and Sergey V. Nuzhdin

New estimates of the rates and effects of mildly deleterious mutation in Drosophila melanogaster

• Robert P. Hirt,
• John M. Logsdon, Jr.,
• Bryan Healy,
• Michael W. Dorey,
• W. Ford Doolittle,
• and T. Martin Embley

Microsporidia are related to Fungi: Evidence from the largest subunit of RNA polymerase II and other proteins

• Makoto Yoshioka,
• Pamela M. Vacek,
• Tina Poseno,
• Robert Silver,
• and Barry A. Finette