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THIS WEEK IN PNAS

In This Issue
PNAS 2008 105: 6503-6504. [Full Text] [PDF]  

COMMENTARIES

Stephen Polasky

Why conservation planning needs socioeconomic data
PNAS 2008 105: 6505-6506; published online on April 30, 2008, 10.1073/pnas.0802815105 [Extract] [Full Text] [PDF]  
See companion article on page 6498 in issue 17 of volume 105

PERSPECTIVES

Ariel J. Blocker, Janet E. Deane, Andreas K. J. Veenendaal, Pietro Roversi, Julie L. Hodgkinson, Steven Johnson, and Susan M. Lea

What's the point of the type III secretion system needle?
PNAS 2008 105: 6507-6513; published online on May 5, 2008, 10.1073/pnas.0708344105 [Abstract] [Full Text] [Figures Only] [PDF]  

PHYSICAL SCIENCES

Chemistry

Wenyu Zhang, William R. Dichtel, Adam Z. Stieg, Diego Benítez, James K. Gimzewski, James R. Heath, and J. Fraser Stoddart

Folding of a donor–acceptor polyrotaxane by using noncovalent bonding interactions
PNAS 2008 105: 6514-6519; published online on April 30, 2008, 10.1073/pnas.0711072105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Ram P. Garg, Xuelei L. Qian, Lawrence B. Alemany, Sean Moran, and Ronald J. Parry

Investigations of valanimycin biosynthesis: Elucidation of the role of seryl-tRNA
PNAS 2008 105: 6543-6547; published online on May 1, 2008, 10.1073/pnas.0708957105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Geology

C. Vance Haynes, Jr

Younger Dryas "black mats" and the Rancholabrean termination in North America
PNAS 2008 105: 6520-6525; published online on April 24, 2008, 10.1073/pnas.0800560105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

T. Bosak, R. M. Losick, and A. Pearson

A polycyclic terpenoid that alleviates oxidative stress
PNAS 2008 105: 6725-6729; published online on April 24, 2008, 10.1073/pnas.0800199105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Geophysics

Koichiro Umemoto and Renata M. Wentzcovitch

Prediction of an U₂S₃-type polymorph of Al₂O₃ at 3.7 Mbar
PNAS 2008 105: 6526-6530; published online on May 1, 2008, 10.1073/pnas.0711925105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

BIOLOGICAL SCIENCES

Applied Biological Sciences

Anura P. Jayasooriya, Michael L. Mathai, Lesley L. Walker, Denovan P. Begg, Derek A. Denton, David Cameron-Smith, Gary F. Egan, Michael J. McKinley, Paula D. Rodger, Andrew J. Sinclair, John D. Wark, Harrison S. Weisinger, Mark Jois, and Richard S. Weisinger

Mice lacking angiotensin-converting enzyme have increased energy expenditure, with reduced fat mass and improved glucose clearance
PNAS 2008 105: 6531-6536; published online on April 28, 2008, 10.1073/pnas.0802690105 [Abstract] [Full Text] [Figures Only] [PDF]  

Zeeshan H. Syedain, Justin S. Weinberg, and Robert T. Tranquillo

Cyclic distension of fibrin-based tissue constructs: Evidence of adaptation during growth of engineered connective tissue
PNAS 2008 105: 6537-6542; published online on April 24, 2008, 10.1073/pnas.0711217105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Biochemistry

Ram P. Garg, Xuelei L. Qian, Lawrence B. Alemany, Sean Moran, and Ronald J. Parry

Investigations of valanimycin biosynthesis: Elucidation of the role of seryl-tRNA
PNAS 2008 105: 6543-6547; published online on May 1, 2008, 10.1073/pnas.0708957105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Dirk Hubmacher, Ehab I. El-Hallous, Valentin Nelea, Mari T. Kaartinen, Eunice R. Lee, and Dieter P. Reinhardt

Biogenesis of extracellular microfibrils: Multimerization of the fibrillin-1 C terminus into bead-like structures enables self-assembly
PNAS 2008 105: 6548-6553; published online on April 30, 2008, 10.1073/pnas.0706335105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Manas K. Chattopadhyay, Myung Hee Park, and Herbert Tabor

Hypusine modification for growth is the major function of spermidine in Saccharomyces cerevisiae polyamine auxotrophs grown in limiting spermidine
PNAS 2008 105: 6554-6559; published online on May 1, 2008, 10.1073/pnas.0710970105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Elizabeth Ficko-Blean, Keith A. Stubbs, Oksana Nemirovsky, David J. Vocadlo, and Alisdair B. Boraston

Structural and mechanistic insight into the basis of mucopolysaccharidosis IIIB
PNAS 2008 105: 6560-6565; published online on April 28, 2008, 10.1073/pnas.0711491105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Joseph D. Schrag, Sarn Jiralerspong, Myriam Banville, Maria Luz Jaramillo, and Maureen D. O'Connor-McCourt

The crystal structure and dimerization interface of GADD45
PNAS 2008 105: 6566-6571; published online on April 29, 2008, 10.1073/pnas.0800086105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Andrea Alfieri, Enrico Malito, Roberto Orru, Marco W. Fraaije, and Andrea Mattevi

Revealing the moonlighting role of NADP in the structure of a flavin-containing monooxygenase
PNAS 2008 105: 6572-6577; published online on April 28, 2008, 10.1073/pnas.0800859105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Jin Huang, Akiko Koide, Koki Makabe, and Shohei Koide

Design of protein function leaps by directed domain interface evolution
PNAS 2008 105: 6578-6583; published online on April 29, 2008, 10.1073/pnas.0801097105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Jidong Zhu, John Blenis, and Junying Yuan

Activation of PI3K/Akt and MAPK pathways regulates Myc-mediated transcription by phosphorylating and promoting the degradation of Mad1
PNAS 2008 105: 6584-6589; published online on May 1, 2008, 10.1073/pnas.0802785105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Biophysics

Hongtao Chen, Sungwon Kim, Li Li, Shuyi Wang, Kinam Park, and Ji-Xin Cheng

Release of hydrophobic molecules from polymer micelles into cell membranes revealed by Förster resonance energy transfer imaging
PNAS 2008 105: 6596-6601; published online on April 29, 2008, 10.1073/pnas.0707046105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Xiaohui Qu, Glenna J. Smith, Kang Taek Lee, Tobin R. Sosnick, Tao Pan, and Norbert F. Scherer

Single-molecule nonequilibrium periodic Mg²⁺-concentration jump experiments reveal details of the early folding pathways of a large RNA
PNAS 2008 105: 6602-6607; published online on April 30, 2008, 10.1073/pnas.0801436105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Cell Biology

Bernhard Schmierer, Alexander L. Tournier, Paul A. Bates, and Caroline S. Hill

Mathematical modeling identifies Smad nucleocytoplasmic shuttling as a dynamic signal-interpreting system
PNAS 2008 105: 6608-6613; published online on April 28, 2008, 10.1073/pnas.0710134105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Noriyuki Sonoda, Takeshi Imamura, Takeshi Yoshizaki, Jennie L. Babendure, Juu-Chin Lu, and Jerrold M. Olefsky

β-Arrestin-1 mediates glucagon-like peptide-1 signaling to insulin secretion in cultured pancreatic β cells
PNAS 2008 105: 6614-6619; published online on April 29, 2008, 10.1073/pnas.0710402105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Susanna Purhonen, Jarmo Palm, Derrick Rossi, Nina Kaskenpää, Iiro Rajantie, Seppo Ylä-Herttuala, Kari Alitalo, Irving L. Weissman, and Petri Salven Bone marrow-derived circulating endothelial precursors do not contribute to vascular endothelium and are not needed for tumor growth PNAS 2008 105: 6620-6625; published online on April 28, 2008, 10.1073/pnas.0710516105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information] OPEN ACCESS ARTICLE

Sungsoo Na, Olivier Collin, Farhan Chowdhury, Bernard Tay, Mingxing Ouyang, Yingxiao Wang, and Ning Wang

Rapid signal transduction in living cells is a unique feature of mechanotransduction
PNAS 2008 105: 6626-6631; published online on May 2, 2008, 10.1073/pnas.0711704105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Syed A. Ali, Sayyed K. Zaidi, Caroline S. Dacwag, Nunciada Salma, Daniel W. Young, Abdul R. Shakoori, Martin A. Montecino, Jane B. Lian, Andre J. van Wijnen, Anthony N. Imbalzano, Gary S. Stein, and Janet L. Stein

Phenotypic transcription factors epigenetically mediate cell growth control
PNAS 2008 105: 6632-6637; published online on April 29, 2008, 10.1073/pnas.0800970105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Xu Peng, Xiaoyang Wu, Joseph E. Druso, Huijun Wei, Ann Yong-Jin Park, Marc S. Kraus, Ana Alcaraz, Ju Chen, Shu Chien, Richard A. Cerione, and Jun-Lin Guan

Cardiac developmental defects and eccentric right ventricular hypertrophy in cardiomyocyte focal adhesion kinase (FAK) conditional knockout mice
PNAS 2008 105: 6638-6643; published online on April 30, 2008, 10.1073/pnas.0802319105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Developmental Biology

Inés Carrera, Florence Janody, Nina Leeds, Fabien Duveau, and Jessica E. Treisman

Pygopus activates Wingless target gene transcription through the mediator complex subunits Med12 and Med13
PNAS 2008 105: 6644-6649; published online on May 1, 2008, 10.1073/pnas.0709749105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Qingsong Zhu, Yasuyuki Arakane, Richard W. Beeman, Karl J. Kramer, and Subbaratnam Muthukrishnan Functional specialization among insect chitinase family genes revealed by RNA interference PNAS 2008 105: 6650-6655; published online on April 24, 2008, 10.1073/pnas.0800739105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information] OPEN ACCESS ARTICLE

Xiaolin Gao, Peri Tate, Ping Hu, Robert Tjian, William C. Skarnes, and Zhong Wang

ES cell pluripotency and germ-layer formation require the SWI/SNF chromatin remodeling component BAF250a
PNAS 2008 105: 6656-6661; published online on April 30, 2008, 10.1073/pnas.0801802105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Joan Isern, Stuart T. Fraser, Zhiyong He, and Margaret H. Baron

The fetal liver is a niche for maturation of primitive erythroid cells
PNAS 2008 105: 6662-6667; published online on April 29, 2008, 10.1073/pnas.0802032105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Environmental Sciences

Lucas N. Joppa, Scott R. Loarie, and Stuart L. Pimm On the protection of "protected areas" PNAS 2008 105: 6673-6678; published online on May 1, 2008, 10.1073/pnas.0802471105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information] [Supporting Information] OPEN ACCESS ARTICLE

Evolution

Shigehiro Kuraku, Yoko Takio, Koji Tamura, Hideaki Aono, Axel Meyer, and Shigeru Kuratani

Noncanonical role of Hox14 revealed by its expression patterns in lamprey and shark
PNAS 2008 105: 6679-6683; published online on April 30, 2008, 10.1073/pnas.0710947105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Immunology

Hui Xu, Timothy B. Oriss, Mingjian Fei, Adam C. Henry, Barbro N. Melgert, Li Chen, Andrew L. Mellor, David H. Munn, Charles G. Irvin, Prabir Ray, and Anuradha Ray

Indoleamine 2,3-dioxygenase in lung dendritic cells promotes Th2 responses and allergic inflammation
PNAS 2008 105: 6690-6695; published online on April 24, 2008, 10.1073/pnas.0708809105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Brett K. Kaiser, Juan Carlos Pizarro, Julie Kerns, and Roland K. Strong

Structural basis for NKG2A/CD94 recognition of HLA-E
PNAS 2008 105: 6696-6701; published online on April 30, 2008, 10.1073/pnas.0802736105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Medical Sciences

Simon K. Michael, Howard K. Surks, Yuepeng Wang, Yan Zhu, Robert Blanton, Michelle Jamnongjit, Mark Aronovitz, Wendy Baur, Kenichi Ohtani, Michael K. Wilkerson, Adrian D. Bonev, Mark T. Nelson, Richard H. Karas, and Michael E. Mendelsohn

High blood pressure arising from a defect in vascular function
PNAS 2008 105: 6702-6707; published online on April 30, 2008, 10.1073/pnas.0802128105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Kajsa Paulsson, Jean-Baptiste Cazier, Finlay MacDougall, Jane Stevens, Irina Stasevich, Nikoletta Vrcelj, Tracy Chaplin, Debra M. Lillington, T. Andrew Lister, and Bryan D. Young

Microdeletions are a general feature of adult and adolescent acute lymphoblastic leukemia: Unexpected similarities with pediatric disease
PNAS 2008 105: 6708-6713; published online on May 5, 2008, 10.1073/pnas.0800408105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Jonathan L. Tobin, Matt Di Franco, Erica Eichers, Helen May-Simera, Monica Garcia, Jiong Yan, Robyn Quinlan, Monica J. Justice, Raoul C. Hennekam, James Briscoe, Masazumi Tada, Roberto Mayor, Alan J. Burns, James R. Lupski, Peter Hammond, and Philip L. Beales Inhibition of neural crest migration underlies craniofacial dysmorphology and Hirschsprung's disease in Bardet–Biedl syndrome PNAS 2008 105: 6714-6719; published online on April 28, 2008, 10.1073/pnas.0707057105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information] OPEN ACCESS ARTICLE

Mitsuru Matsumoto, Yiqing Zhou, Shinji Matsuo, Hideki Nakanishi, Kenji Hirose, Hajimu Oura, Seiji Arase, Akemi Ishida-Yamamoto, Yoshimi Bando, Keisuke Izumi, Hiroshi Kiyonari, Naoko Oshima, Rika Nakayama, Akemi Matsushima, Fumiko Hirota, Yasuhiro Mouri, Noriyuki Kuroda, Shigetoshi Sano, and David D. Chaplin

Targeted deletion of the murine corneodesmosin gene delineates its essential role in skin and hair physiology
PNAS 2008 105: 6720-6724; published online on April 24, 2008, 10.1073/pnas.0709345105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Microbiology

T. Bosak, R. M. Losick, and A. Pearson

A polycyclic terpenoid that alleviates oxidative stress
PNAS 2008 105: 6725-6729; published online on April 24, 2008, 10.1073/pnas.0800199105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Jennifer E. Mendell, Kendall D. Clements, J. Howard Choat, and Esther R. Angert From the Cover: Extreme polyploidy in a large bacterium PNAS 2008 105: 6730-6734; published online on April 29, 2008, 10.1073/pnas.0707522105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]

Melinda J. Faulkner, Karthik Veeravalli, Stéphanie Gon, George Georgiou, and Jon Beckwith

Functional plasticity of a peroxidase allows evolution of diverse disulfide-reducing pathways
PNAS 2008 105: 6735-6740; published online on May 2, 2008, 10.1073/pnas.0801986105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Neuroscience

Alan N. Hampton, Peter Bossaerts, and John P. O'Doherty

Neural correlates of mentalizing-related computations during strategic interactions in humans
PNAS 2008 105: 6741-6746; published online on April 21, 2008, 10.1073/pnas.0711099105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Katharina von Kriegstein, Özgür Dogan, Martina Grüter, Anne-Lise Giraud, Christian A. Kell, Thomas Grüter, Andreas Kleinschmidt, and Stefan J. Kiebel From the Cover: Simulation of talking faces in the human brain improves auditory speech recognition PNAS 2008 105: 6747-6752; published online on April 24, 2008, 10.1073/pnas.0710826105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information] OPEN ACCESS ARTICLE

Wolfram Wetzel, Frank W. Ohl, and Henning Scheich Global versus local processing of frequency-modulated tones in gerbils: An animal model of lateralized auditory cortex functions PNAS 2008 105: 6753-6758; published online on April 24, 2008, 10.1073/pnas.0707844105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information] OPEN ACCESS ARTICLE

Alexander Rauch, Gregor Rainer, and Nikos K. Logothetis The effect of a serotonin-induced dissociation between spiking and perisynaptic activity on BOLD functional MRI PNAS 2008 105: 6759-6764; published online on May 2, 2008, 10.1073/pnas.0800312105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information] OPEN ACCESS ARTICLE

Wen-Lin Liao, Hsiu-Chao Tsai, Hsiao-Fang Wang, Josephine Chang, Kuan-Ming Lu, Hsiao-Lin Wu, Yi-Chao Lee, Ting-Fen Tsai, Hiroshi Takahashi, Michael Wagner, Norbert B. Ghyselinck, Pierre Chambon, and Fu-Chin Liu

Modular patterning of structure and function of the striatum by retinoid receptor signaling
PNAS 2008 105: 6765-6770; published online on April 28, 2008, 10.1073/pnas.0802109105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Physiology

Michael Föller, Susanne Feil, Kamran Ghoreschi, Saisudha Koka, Andrea Gerling, Martin Thunemann, Franz Hofmann, Beat Schuler, Johannes Vogel, Bernd Pichler, Ravi S. Kasinathan, Jan P. Nicolay, Stephan M. Huber, Florian Lang, and Robert Feil

Anemia and splenomegaly in cGKI-deficient mice
PNAS 2008 105: 6771-6776; published online on April 28, 2008, 10.1073/pnas.0708940105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Cheolho Sim and David L. Denlinger

Insulin signaling and FOXO regulate the overwintering diapause of the mosquito Culex pipiens
PNAS 2008 105: 6777-6781; published online on April 30, 2008, 10.1073/pnas.0802067105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Plant Biology

CORRECTIONS

Correction for Assarsson et al., Kinetic analysis of a complete poxvirus transcriptome reveals an immediate-early class of genes [Full Text] [Figures Only] [PDF]  

Correction for Möglich et al., End-to-end distance distributions and intrachain diffusion constants in unfolded polypeptide chains indicate intramolecular hydrogen bond formation [Full Text] [PDF]