Cover illustration
April 29, 2008; 105 (17)
Cover image: Ligands usually bind to proteins by displacing water from the binding site. Intestinal fatty acid-binding protein, a prime example, is filled with water in the apo state (upper right). However, bovine β-lactoglobulin is an extreme exception (lower left); its hydrophobic binding pocket is completely dry. In contrast, carbon nanotubes, despite their highly hydrophobic character, contain ordered chains of water molecules. See the article on pages 6296–6301. Image courtesy of Johan Qvist.
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