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THIS WEEK IN PNAS

In This Issue
PNAS 2008 105: 5947-5948. [Full Text] [PDF]  

LETTERS (Online only)

Richard S. Bedlack, Nicholas Maragakis, and Terry Heiman-Patterson

Lithium may slow progression of amyotrophic lateral sclerosis, but further study is needed
PNAS 2008 105: E17; published online on April 16, 2008, 10.1073/pnas.0801762105 [Extract] [Full Text] [PDF]  

Francesco Fornai, Gabriele Siciliano, Maria Laura Manca, Luigi Murri, Antonio Paparelli, and Stefano Ruggieri

Reply to Bedlack et al.: A small pilot study calls for large clinical trials to evaluate the effects of lithium before prescribing the drug for amyotrophic lateral sclerosis
PNAS 2008 105: E18; published online on April 16, 2008, 10.1073/pnas.0802915105 [Extract] [Full Text] [PDF]  

COMMENTARIES

Gary Rudnick

Vesicular ATP transport is a hard (V)NUT to crack
PNAS 2008 105: 5949-5950; published online on April 15, 2008, 10.1073/pnas.0802774105 [Extract] [Full Text] [Figures Only] [PDF]  
See companion article on page 5683 in issue 15 of volume 105

Leroy Hood

Gene regulatory networks and embryonic specification
PNAS 2008 105: 5951-5952; published online on April 15, 2008, 10.1073/pnas.0801434105 [Extract] [Full Text] [PDF]  
See companion article on page 5955

Astrid A. Prinz

Understanding epilepsy through network modeling
PNAS 2008 105: 5953-5954; published online on April 14, 2008, 10.1073/pnas.0802299105 [Extract] [Full Text] [Figures Only] [PDF]  
See companion article on page 6179

FEATURE ARTICLES

Paola Oliveri, Qiang Tu, and Eric H. Davidson

From the Cover: Feature Article: Global regulatory logic for specification of an embryonic cell lineage
PNAS 2008 105: 5955-5962; published online on April 14, 2008, 10.1073/pnas.0711220105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  
See Commentary on page 5951

PHYSICAL SCIENCES

Applied Mathematics

Chemistry

David J. Belton, Siddharth V. Patwardhan, Vadim V. Annenkov, Elena N. Danilovtseva, and Carole C. Perry

From biosilicification to tailored materials: Optimizing hydrophobic domains and resistance to protonation of polyamines
PNAS 2008 105: 5963-5968; published online on April 17, 2008, 10.1073/pnas.0710809105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Physics

V. Buch, H. Groenzin, I. Li, M. J. Shultz, and E. Tosatti

Proton order in the ice crystal surface
PNAS 2008 105: 5969-5974; published online on April 11, 2008, 10.1073/pnas.0710129105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Text] [Supporting Information]  

SOCIAL SCIENCES

Psychology

Jeffrey N. Rouder, Richard D. Morey, Nelson Cowan, Christopher E. Zwilling, Candice C. Morey, and Michael S. Pratte

An assessment of fixed-capacity models of visual working memory
PNAS 2008 105: 5975-5979; published online on April 17, 2008, 10.1073/pnas.0711295105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

BIOLOGICAL SCIENCES

Agricultural Sciences

Biochemistry

Manuel González-Guerrero and José M. Argüello

Mechanism of Cu⁺-transporting ATPases: Soluble Cu⁺ chaperones directly transfer Cu⁺ to transmembrane transport sites
PNAS 2008 105: 5992-5997; published online on April 15, 2008, 10.1073/pnas.0711446105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Jaiesoon Cho, Jason S. King, Xun Qian, Adrian J. Harwood, and Stephen B. Shears

Dephosphorylation of 2,3-bisphosphoglycerate by MIPP expands the regulatory capacity of the Rapoport–Luebering glycolytic shunt
PNAS 2008 105: 5998-6003; published online on April 14, 2008, 10.1073/pnas.0710980105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Gabriel Sanchez, Danielle Bittencourt, Karine Laud, Jérôme Barbier, Olivier Delattre, Didier Auboeuf, and Martin Dutertre

Alteration of cyclin D1 transcript elongation by a mutated transcription factor up-regulates the oncogenic D1b splice isoform in cancer
PNAS 2008 105: 6004-6009; published online on April 14, 2008, 10.1073/pnas.0710748105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Paul J. Paukstelis and Alan M. Lambowitz

Identification and evolution of fungal mitochondrial tyrosyl-tRNA synthetases with group I intron splicing activity
PNAS 2008 105: 6010-6015; published online on April 14, 2008, 10.1073/pnas.0801722105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Biophysics

Hasan Yardimci, Marilyn van Duffelen, Yinghui Mao, Steven S. Rosenfeld, and Paul R. Selvin

The mitotic kinesin CENP-E is a processive transport motor
PNAS 2008 105: 6016-6021; published online on April 21, 2008, 10.1073/pnas.0711314105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Hyun Suk Jung, Stan A. Burgess, Neil Billington, Melanie Colegrave, Hitesh Patel, Joseph M. Chalovich, Peter D. Chantler, and Peter J. Knight

Conservation of the regulated structure of folded myosin 2 in species separated by at least 600 million years of independent evolution
PNAS 2008 105: 6022-6026; published online on April 14, 2008, 10.1073/pnas.0707846105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Andrij Baumketner, Mary Griffin Krone, and Joan-Emma Shea

Role of the familial Dutch mutation E22Q in the folding and aggregation of the 15–28 fragment of the Alzheimer amyloid-β protein
PNAS 2008 105: 6027-6032; published online on April 11, 2008, 10.1073/pnas.0708193105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Appendix]  

Maarten F. M. Engel, Lucie Khemtémourian, Cécile C. Kleijer, Hans J. D. Meeldijk, Jet Jacobs, Arie J. Verkleij, Ben de Kruijff, J. Antoinette Killian, and Jo W. M. Höppener

Membrane damage by human islet amyloid polypeptide through fibril growth at the membrane
PNAS 2008 105: 6033-6038; published online on April 11, 2008, 10.1073/pnas.0708354105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Saul Lapidus, Bo Han, and Jin Wang

Intrinsic noise, dissipation cost, and robustness of cellular networks: The underlying energy landscape of MAPK signal transduction
PNAS 2008 105: 6039-6044; published online on April 17, 2008, 10.1073/pnas.0708708105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Appendix]  

Anthony H. Keeble, Zahra Khan, Alan Forster, and Leo C. James

TRIM21 is an IgG receptor that is structurally, thermodynamically, and kinetically conserved
PNAS 2008 105: 6045-6050; published online on April 17, 2008, 10.1073/pnas.0800159105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Cell Biology

D. Watling, C. R. Carmo, I. M. Kerr, and A. P. Costa-Pereira

Multiple kinases in the interferon- response
PNAS 2008 105: 6051-6056; published online on April 15, 2008, 10.1073/pnas.0710814105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Ru Feng, Sabrina C. Desbordes, Huafeng Xie, Ester Sanchez Tillo, Fiona Pixley, E. Richard Stanley, and Thomas Graf PU.1 and C/EBP/β convert fibroblasts into macrophage-like cells PNAS 2008 105: 6057-6062; published online on April 18, 2008, 10.1073/pnas.0711961105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information] OPEN ACCESS ARTICLE

Hesham Sadek, Britta Hannack, Elizabeth Choe, Jessica Wang, Shuaib Latif, Mary G. Garry, Daniel J. Garry, Jamie Longgood, Doug E. Frantz, Eric N. Olson, Jenny Hsieh, and Jay W. Schneider

Cardiogenic small molecules that enhance myocardial repair by stem cells
PNAS 2008 105: 6063-6068; published online on April 17, 2008, 10.1073/pnas.0711507105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Judith A. J. Steen, Hanno Steen, Ann Georgi, Kenneth Parker, Michael Springer, Marc Kirchner, Fred Hamprecht, and Marc W. Kirschner Different phosphorylation states of the anaphase promoting complex in response to antimitotic drugs: A quantitative proteomic analysis PNAS 2008 105: 6069-6074; published online on April 17, 2008, 10.1073/pnas.0709807104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information] OPEN ACCESS ARTICLE

Isabelle Colas, Peter Shaw, Pilar Prieto, Michael Wanous, Wolfgang Spielmeyer, Rohit Mago, and Graham Moore

Effective chromosome pairing requires chromatin remodeling at the onset of meiosis
PNAS 2008 105: 6075-6080; published online on April 15, 2008, 10.1073/pnas.0801521105 [Abstract] [Full Text] [Figures Only] [PDF]  

Developmental Biology

Paola Oliveri, Qiang Tu, and Eric H. Davidson

From the Cover: Feature Article: Global regulatory logic for specification of an embryonic cell lineage
PNAS 2008 105: 5955-5962; published online on April 14, 2008, 10.1073/pnas.0711220105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  
See Commentary on page 5951

Jinsheng Weng, Jian Luo, Xuhong Cheng, Chang Jin, Xiangtian Zhou, Jia Qu, LiLi Tu, Di Ai, Dali Li, Jun Wang, James F. Martin, Brad A. Amendt, and Mingyao Liu

Deletion of G protein-coupled receptor 48 leads to ocular anterior segment dysgenesis (ASD) through down-regulation of Pitx2
PNAS 2008 105: 6081-6086; published online on April 18, 2008, 10.1073/pnas.0708257105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Ecology

Evolution

Feng Gao and Eric H. Davidson

Transfer of a large gene regulatory apparatus to a new developmental address in echinoid evolution
PNAS 2008 105: 6091-6096; published online on April 14, 2008, 10.1073/pnas.0801201105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Lee Hsiang Liow, Mikael Fortelius, Ella Bingham, Kari Lintulaakso, Heikki Mannila, Larry Flynn, and Nils Chr. Stenseth

Higher origination and extinction rates in larger mammals
PNAS 2008 105: 6097-6102; published online on April 15, 2008, 10.1073/pnas.0709763105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Genetics

Kathryn A. Tworkowski, Abhishek A. Chakraborty, Andrew V. Samuelson, Yvette R. Seger, Masako Narita, Gregory J. Hannon, Scott W. Lowe, and William P. Tansey

Adenovirus E1A targets p400 to induce the cellular oncoprotein Myc
PNAS 2008 105: 6103-6108; published online on April 14, 2008, 10.1073/pnas.0802095105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Immunology

Nienke Vrisekoop, Ineke den Braber, Anne Bregje de Boer, An F. C. Ruiter, Mariëtte T. Ackermans, Saskia N. van der Crabben, Elise H. R. Schrijver, Gerrit Spierenburg, Hans P. Sauerwein, Mette D. Hazenberg, Rob J. de Boer, Frank Miedema, José A. M. Borghans, and Kiki Tesselaar

Sparse production but preferential incorporation of recently produced naïve T cells in the human peripheral pool
PNAS 2008 105: 6115-6120; published online on April 17, 2008, 10.1073/pnas.0709713105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Boris Calderon, Anish Suri, Mark J. Miller, and Emil R. Unanue Dendritic cells in islets of Langerhans constitutively present β cell-derived peptides bound to their class II MHC molecules PNAS 2008 105: 6121-6126; published online on April 21, 2008, 10.1073/pnas.0801973105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information] OPEN ACCESS ARTICLE

Medical Sciences

Yulan Wang, Jürg Utzinger, Jasmina Saric, Jia V. Li, Jean Burckhardt, Stephan Dirnhofer, Jeremy K. Nicholson, Burton H. Singer, Reto Brun, and Elaine Holmes

Global metabolic responses of mice to Trypanosoma brucei brucei infection
PNAS 2008 105: 6127-6132; published online on April 14, 2008, 10.1073/pnas.0801777105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Mitsuyuki Matsumoto, Richard E. Straub, Stefano Marenco, Kristin K. Nicodemus, Shun-ichiro Matsumoto, Akihiko Fujikawa, Sosuke Miyoshi, Miwako Shobo, Shinji Takahashi, Junko Yarimizu, Masatoshi Yuri, Masashi Hiramoto, Shuji Morita, Hiroyuki Yokota, Takeshi Sasayama, Kazuhiro Terai, Masayasu Yoshino, Akira Miyake, Joseph H. Callicott, Michael F. Egan, Andreas Meyer-Lindenberg, Lucas Kempf, Robyn Honea, Radha Krishna Vakkalanka, Jun Takasaki, Masazumi Kamohara, Takatoshi Soga, Hideki Hiyama, Hiroyuki Ishii, Ayako Matsuo, Shintaro Nishimura, Nobuya Matsuoka, Masato Kobori, Hitoshi Matsushime, Masao Katoh, Kiyoshi Furuichi, and Daniel R. Weinberger The evolutionarily conserved G protein-coupled receptor SREB2/GPR85 influences brain size, behavior, and vulnerability to schizophrenia PNAS 2008 105: 6133-6138; published online on April 14, 2008, 10.1073/pnas.0710717105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information] OPEN ACCESS ARTICLE

May-Yun Wang, Paul Grayburn, Shuyuan Chen, Mariella Ravazzola, Lelio Orci, and Roger H. Unger

Adipogenic capacity and the susceptibility to type 2 diabetes and metabolic syndrome
PNAS 2008 105: 6139-6144; published online on April 14, 2008, 10.1073/pnas.0801981105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Microbiology

Orit Gefen, Chana Gabay, Michael Mumcuoglu, Giora Engel, and Nathalie Q. Balaban

Single-cell protein induction dynamics reveals a period of vulnerability to antibiotics in persister bacteria
PNAS 2008 105: 6145-6149; published online on April 21, 2008, 10.1073/pnas.0711712105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Chun Kim, Sarah Wilcox-Adelman, Yasuyo Sano, Wei-Jen Tang, R. John Collier, and Jin Mo Park From the Cover: Antiinflammatory cAMP signaling and cell migration genes co-opted by the anthrax bacillus PNAS 2008 105: 6150-6155; published online on April 21, 2008, 10.1073/pnas.0800105105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]

Jana Stöckel, Eric A. Welsh, Michelle Liberton, Rangesh Kunnvakkam, Rajeev Aurora, and Himadri B. Pakrasi

Global transcriptomic analysis of Cyanothece 51142 reveals robust diurnal oscillation of central metabolic processes
PNAS 2008 105: 6156-6161; published online on April 21, 2008, 10.1073/pnas.0711068105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Neuroscience

J. M. Coates and J. Herbert

Endogenous steroids and financial risk taking on a London trading floor
PNAS 2008 105: 6167-6172; published online on April 14, 2008, 10.1073/pnas.0704025105 [Abstract] [Full Text] [Figures Only] [PDF]  

Tom Eichele, Stefan Debener, Vince D. Calhoun, Karsten Specht, Andreas K. Engel, Kenneth Hugdahl, D. Yves von Cramon, and Markus Ullsperger Prediction of human errors by maladaptive changes in event-related brain networks PNAS 2008 105: 6173-6178; published online on April 21, 2008, 10.1073/pnas.0708965105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information] OPEN ACCESS ARTICLE

Robert J. Morgan and Ivan Soltesz From the Cover: Nonrandom connectivity of the epileptic dentate gyrus predicts a major role for neuronal hubs in seizures PNAS 2008 105: 6179-6184; published online on March 28, 2008, 10.1073/pnas.0801372105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information] OPEN ACCESS ARTICLE   See Commentary on page 5953

Era Taoufik, Edwige Petit, Didier Divoux, Vivian Tseveleki, Manuela Mengozzi, Michael L. Roberts, Samuel Valable, Pietro Ghezzi, John Quackenbush, Michael Brines, Anthony Cerami, and Lesley Probert TNF receptor I sensitizes neurons to erythropoietin- and VEGF-mediated neuroprotection after ischemic and excitotoxic injury PNAS 2008 105: 6185-6190; published online on April 14, 2008, 10.1073/pnas.0801447105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information] OPEN ACCESS ARTICLE

Plant Biology

Ran Hovav, Joshua A. Udall, Bhupendra Chaudhary, Ryan Rapp, Lex Flagel, and Jonathan F. Wendel

Partitioned expression of duplicated genes during development and evolution of a single cell in a polyploid plant
PNAS 2008 105: 6191-6195; published online on April 17, 2008, 10.1073/pnas.0711569105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Rohit Shroff, Fredd Vergara, Alexander Muck, Ales Svatos, and Jonathan Gershenzon Nonuniform distribution of glucosinolates in Arabidopsis thaliana leaves has important consequences for plant defense PNAS 2008 105: 6196-6201; published online on April 11, 2008, 10.1073/pnas.0711730105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information] OPEN ACCESS ARTICLE

Psychology

Xiangrui Li, Zhong-Lin Lu, Bosco S. Tjan, Barbara A. Dosher, and Wilson Chu

Blood oxygenation level-dependent contrast response functions identify mechanisms of covert attention in early visual areas
PNAS 2008 105: 6202-6207; published online on April 14, 2008, 10.1073/pnas.0801390105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

CORRECTIONS

Correction for Wood et al., 6-Ethynylthieno[3,2-d]- and 6-ethynylthieno[2,3-d]pyrimidin-4-anilines as tunable covalent modifiers of ErbB kinases [Full Text] [Figures Only] [PDF]  

Correction for del Mercato et al., Charge transport and intrinsic fluorescence in amyloid-like fibrils [Full Text] [PDF]