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THIS WEEK IN PNAS

In This Issue
PNAS 2008 105: 5651-5652. [Full Text] [PDF]  

COMMENTARIES

John H. Wilson

Knockout punches with a fistful of zinc fingers
PNAS 2008 105: 5653-5654; published online on April 9, 2008, 10.1073/pnas.0802298105 [Extract] [Full Text] [Figures Only] [PDF]  
See companion article on page 5809

Christopher T. Walsh and Elizabeth M. Nolan

Morphing peptide backbones into heterocycles
PNAS 2008 105: 5655-5656; published online on April 8, 2008, 10.1073/pnas.0802300105 [Extract] [Full Text] [Figures Only] [PDF]  
See companion article on page 5879

PHYSICAL SCIENCES

Chemistry

Youngmi Kim, Zehui Cao, and Weihong Tan

Molecular assembly for high-performance bivalent nucleic acid inhibitor
PNAS 2008 105: 5664-5669; published online on April 8, 2008, 10.1073/pnas.0711803105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Ping Lin, Vinod K. Batra, Lars C. Pedersen, William A. Beard, Samuel H. Wilson, and Lee G. Pedersen

Incorrect nucleotide insertion at the active site of a G:A mismatch catalyzed by DNA polymerase β
PNAS 2008 105: 5670-5674; published online on April 7, 2008, 10.1073/pnas.0801257105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Physics

S. Condamin, V. Tejedor, R. Voituriez, O. Bénichou, and J. Klafter

Probing microscopic origins of confined subdiffusion by first-passage observables
PNAS 2008 105: 5675-5680; published online on April 7, 2008, 10.1073/pnas.0712158105 [Abstract] [Full Text] [Figures Only] [PDF]  

SOCIAL SCIENCES

Social Sciences

Douglas Almond and Lena Edlund

Son-biased sex ratios in the 2000 United States Census
PNAS 2008 105: 5681-5682; published online on March 31, 2008, 10.1073/pnas.0800703105 [Abstract] [Full Text] [Figures Only] [PDF]  

BIOLOGICAL SCIENCES

Biochemistry

Youngmi Kim, Zehui Cao, and Weihong Tan

Molecular assembly for high-performance bivalent nucleic acid inhibitor
PNAS 2008 105: 5664-5669; published online on April 8, 2008, 10.1073/pnas.0711803105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Ping Lin, Vinod K. Batra, Lars C. Pedersen, William A. Beard, Samuel H. Wilson, and Lee G. Pedersen

Incorrect nucleotide insertion at the active site of a G:A mismatch catalyzed by DNA polymerase β
PNAS 2008 105: 5670-5674; published online on April 7, 2008, 10.1073/pnas.0801257105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Keisuke Sawada, Noriko Echigo, Narinobu Juge, Takaaki Miyaji, Masato Otsuka, Hiroshi Omote, Akitsugu Yamamoto, and Yoshinori Moriyama From the Cover: Identification of a vesicular nucleotide transporter PNAS 2008 105: 5683-5686; published online on March 28, 2008, 10.1073/pnas.0800141105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]   See Commentary on page 5949

Zhibing Lu, Debra Dunaway-Mariano, and Karen N. Allen

The catalytic scaffold of the haloalkanoic acid dehalogenase enzyme superfamily acts as a mold for the trigonal bipyramidal transition state
PNAS 2008 105: 5687-5692; published online on April 8, 2008, 10.1073/pnas.0710800105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Fernando A. Rodriguez, Carlos Contreras, Víctor Bolanos-Garcia, and Jorge E. Allende

Protein kinase CK2 as an ectokinase: The role of the regulatory CK2β subunit
PNAS 2008 105: 5693-5698; published online on April 7, 2008, 10.1073/pnas.0802065105 [Abstract] [Full Text] [Figures Only] [PDF]  

Sarah V. Lipchock and Scott A. Strobel

A relaxed active site after exon ligation by the group I intron
PNAS 2008 105: 5699-5704; published online on April 11, 2008, 10.1073/pnas.0712016105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Melanie Gertz, Frank Fischer, Dirk Wolters, and Clemens Steegborn

Activation of the lifespan regulator p66^Shc through reversible disulfide bond formation
PNAS 2008 105: 5705-5709; published online on April 14, 2008, 10.1073/pnas.0800691105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Nancy Adamek, Lynne M. Coluccio, and Michael A. Geeves Calcium sensitivity of the cross-bridge cycle of Myo1c, the adaptation motor in the inner ear PNAS 2008 105: 5710-5715; published online on April 7, 2008, 10.1073/pnas.0710520105 [Abstract] [Full Text] [Figures Only] [PDF] OPEN ACCESS ARTICLE

Mark R. Brown, Kevin D. Clark, Monika Gulia, Zhangwu Zhao, Stephen F. Garczynski, Joe W. Crim, Richard J. Suderman, and Michael R. Strand

An insulin-like peptide regulates egg maturation and metabolism in the mosquito Aedes aegypti
PNAS 2008 105: 5716-5721; published online on April 7, 2008, 10.1073/pnas.0800478105 [Abstract] [Full Text] [Figures Only] [PDF]  

Eric R. Geertsma, Maarten Groeneveld, Dirk-Jan Slotboom, and Bert Poolman

Quality control of overexpressed membrane proteins
PNAS 2008 105: 5722-5727; published online on April 7, 2008, 10.1073/pnas.0802190105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Xiaodong Zhang and Thomas C. Bruice

Enzymatic mechanism and product specificity of SET-domain protein lysine methyltransferases
PNAS 2008 105: 5728-5732; published online on April 7, 2008, 10.1073/pnas.0801788105 [Abstract] [Full Text] [Figures Only] [PDF]  

Alejandra Yep, George L. Kenyon, and Michael J. McLeish

Saturation mutagenesis of putative catalytic residues of benzoylformate decarboxylase provides a challenge to the accepted mechanism
PNAS 2008 105: 5733-5738; published online on April 8, 2008, 10.1073/pnas.0709657105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Se-Young Son, Jichun Ma, Youhei Kondou, Masato Yoshimura, Eiki Yamashita, and Tomitake Tsukihara

Structure of human monoamine oxidase A at 2.2-Å resolution: The control of opening the entry for substrates/inhibitors
PNAS 2008 105: 5739-5744; published online on April 7, 2008, 10.1073/pnas.0710626105 [Abstract] [Full Text] [Figures Only] [PDF]  

Alex Yick-Lun So, Samantha B. Cooper, Brian J. Feldman, Mitra Manuchehri, and Keith R. Yamamoto Conservation analysis predicts in vivo occupancy of glucocorticoid receptor-binding sequences at glucocorticoid-induced genes PNAS 2008 105: 5745-5749; published online on April 11, 2008, 10.1073/pnas.0801551105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information] OPEN ACCESS ARTICLE

Rachid Essalmani, Ahmed Zaid, Jadwiga Marcinkiewicz, Ann Chamberland, Antonella Pasquato, Nabil G. Seidah, and Annik Prat In vivo functions of the proprotein convertase PC5/6 during mouse development: Gdf11 is a likely substrate PNAS 2008 105: 5750-5755; published online on March 31, 2008, 10.1073/pnas.0709428105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information] OPEN ACCESS ARTICLE

Biophysics

Johannes Wiedersich, Simone Köhler, Arne Skerra, and Josef Friedrich

Temperature and pressure dependence of protein stability: The engineered fluorescein-binding lipocalin FluA shows an elliptic phase diagram
PNAS 2008 105: 5756-5761; published online on April 7, 2008, 10.1073/pnas.0710409105 [Abstract] [Full Text] [Figures Only] [PDF]  

Mark Wells, Henning Tidow, Trevor J. Rutherford, Phineus Markwick, Malene Ringkjobing Jensen, Efstratios Mylonas, Dmitri I. Svergun, Martin Blackledge, and Alan R. Fersht

Structure of tumor suppressor p53 and its intrinsically disordered N-terminal transactivation domain
PNAS 2008 105: 5762-5767; published online on April 7, 2008, 10.1073/pnas.0801353105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Cell Biology

Kathryn B. Horwitz, Wendy W. Dye, Joshua Chuck Harrell, Peter Kabos, and Carol A. Sartorius

Rare steroid receptor-negative basal-like tumorigenic cells in luminal subtype human breast cancer xenografts
PNAS 2008 105: 5774-5779; published online on April 7, 2008, 10.1073/pnas.0706216105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Developmental Biology

Takako Kondo, Patrick L. Sheets, David A. Zopf, Heather L. Aloor, Theodore R. Cummins, Rebecca J. Chan, and Eri Hashino

Tlx3 exerts context-dependent transcriptional regulation and promotes neuronal differentiation from embryonic stem cells
PNAS 2008 105: 5780-5785; published online on April 7, 2008, 10.1073/pnas.0708704105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Evolution

Alexander G. S. C. Liu, Erik R. Seiffert, and Elwyn L. Simons

Stable isotope evidence for an amphibious phase in early proboscidean evolution
PNAS 2008 105: 5786-5791; published online on April 14, 2008, 10.1073/pnas.0800884105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Bernard C. Lamb, Snehal Mandaokar, Basma Bahsoun, Isabella Grishkan, and Eviatar Nevo

Differences in spontaneous mutation frequencies as a function of environmental stress in soil fungi at "Evolution Canyon," Israel
PNAS 2008 105: 5792-5796; published online on April 9, 2008, 10.1073/pnas.0801995105 [Abstract] [Full Text] [PDF]  

Chaolin Zhang, Wen-Hsiung Li, Adrian R. Krainer, and Michael Q. Zhang

RNA landscape of evolution for optimal exon and intron discrimination
PNAS 2008 105: 5797-5802; published online on April 7, 2008, 10.1073/pnas.0801692105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Luis David Alcaraz, Gabriela Olmedo, Germán Bonilla, René Cerritos, Gustavo Hernández, Alfredo Cruz, Enrique Ramírez, Catherine Putonti, Beatriz Jiménez, Eva Martínez, Varinia López, Jacqueline L. Arvizu, Francisco Ayala, Francisco Razo, Juan Caballero, Janet Siefert, Luis Eguiarte, Jean-Philippe Vielle, Octavio Martínez, Valeria Souza, Alfredo Herrera-Estrella, and Luis Herrera-Estrella

The genome of Bacillus coahuilensis reveals adaptations essential for survival in the relic of an ancient marine environment
PNAS 2008 105: 5803-5808; published online on April 11, 2008, 10.1073/pnas.0800981105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Genetics

Gaganpreet K. Sidhu, Sachin Rustgi, Mustafa N. Shafqat, Diter von Wettstein, and Kulvinder S. Gill

Fine structure mapping of a gene-rich region of wheat carrying Ph1, a suppressor of crossing over between homoeologous chromosomes
PNAS 2008 105: 5815-5820; published online on April 8, 2008, 10.1073/pnas.0800931105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Laurence Decourty, Cosmin Saveanu, Kenza Zemam, Florence Hantraye, Emmanuel Frachon, Jean-Claude Rousselle, Micheline Fromont-Racine, and Alain Jacquier Linking functionally related genes by sensitive and quantitative characterization of genetic interaction profiles PNAS 2008 105: 5821-5826; published online on April 11, 2008, 10.1073/pnas.0710533105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information] OPEN ACCESS ARTICLE

L. Meadow Anderson and Haw Yang

DNA looping can enhance lysogenic CI transcription in phage lambda
PNAS 2008 105: 5827-5832; published online on April 7, 2008, 10.1073/pnas.0705570105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Ruslan Kalendar, Jaakko Tanskanen, Wei Chang, Kristiina Antonius, Hanan Sela, Ofer Peleg, and Alan H. Schulman

Cassandra retrotransposons carry independently transcribed 5S RNA
PNAS 2008 105: 5833-5838; published online on April 11, 2008, 10.1073/pnas.0709698105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Immunology

Nina F. Rose, Jean Publicover, Anasuya Chattopadhyay, and John K. Rose

Hybrid alphavirus–rhabdovirus propagating replicon particles are versatile and potent vaccine vectors
PNAS 2008 105: 5839-5843; published online on April 7, 2008, 10.1073/pnas.0800280105 [Abstract] [Full Text] [Figures Only] [PDF]  

Medical Sciences

Hannah H. Alphs, Ratish Gambhira, Balasubramanyam Karanam, Jeffrey N. Roberts, Subhashini Jagu, John T. Schiller, Weiguang Zeng, David C. Jackson, and Richard B. S. Roden Protection against heterologous human papillomavirus challenge by a synthetic lipopeptide vaccine containing a broadly cross-neutralizing epitope of L2 PNAS 2008 105: 5850-5855; published online on April 14, 2008, 10.1073/pnas.0800868105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information] OPEN ACCESS ARTICLE

Marius Wernig, Jian-Ping Zhao, Jan Pruszak, Eva Hedlund, Dongdong Fu, Frank Soldner, Vania Broccoli, Martha Constantine-Paton, Ole Isacson, and Rudolf Jaenisch

Neurons derived from reprogrammed fibroblasts functionally integrate into the fetal brain and improve symptoms of rats with Parkinson's disease
PNAS 2008 105: 5856-5861; published online on April 7, 2008, 10.1073/pnas.0801677105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Meihui Pan, Vatsala Maitin, Sajesh Parathath, Ursula Andreo, Sharron X. Lin, Carly St. Germain, Zemin Yao, Frederick R. Maxfield, Kevin Jon Williams, and Edward A. Fisher

Presecretory oxidation, aggregation, and autophagic destruction of apoprotein-B: A pathway for late-stage quality control
PNAS 2008 105: 5862-5867; published online on April 7, 2008, 10.1073/pnas.0707460104 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Jodi L. McBride, Ryan L. Boudreau, Scott Q. Harper, Patrick D. Staber, Alex Mas Monteys, Inâs Martins, Brian L. Gilmore, Haim Burstein, Richard W. Peluso, Barry Polisky, Barrie J. Carter, and Beverly L. Davidson

Artificial miRNAs mitigate shRNA-mediated toxicity in the brain: Implications for the therapeutic development of RNAi
PNAS 2008 105: 5868-5873; published online on April 8, 2008, 10.1073/pnas.0801775105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Srikumar Sengupta, Johan A. den Boon, I-How Chen, Michael A. Newton, Stephen A. Stanhope, Yu-Juen Cheng, Chien-Jen Chen, Allan Hildesheim, Bill Sugden, and Paul Ahlquist

MicroRNA 29c is down-regulated in nasopharyngeal carcinomas, up-regulating mRNAs encoding extracellular matrix proteins
PNAS 2008 105: 5874-5878; published online on April 4, 2008, 10.1073/pnas.0801130105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Microbiology

Mohan Liu, Yonglong Zhang, Masayori Inouye, and Nancy A. Woychik

Bacterial addiction module toxin Doc inhibits translation elongation through its association with the 30S ribosomal subunit
PNAS 2008 105: 5885-5890; published online on April 8, 2008, 10.1073/pnas.0711949105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Hendrik Szurmant, Lintao Bu, Charles L. Brooks, III/, and James A. Hoch

An essential sensor histidine kinase controlled by transmembrane helix interactions with its auxiliary proteins
PNAS 2008 105: 5891-5896; published online on April 11, 2008, 10.1073/pnas.0800247105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Betty Y.-W. Chung, W. Allen Miller, John F. Atkins, and Andrew E. Firth

An overlapping essential gene in the Potyviridae
PNAS 2008 105: 5897-5902; published online on April 11, 2008, 10.1073/pnas.0800468105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Hilde-Kari Guttormsen, Lawrence C. Paoletti, Keith G. Mansfield, Wojcieck Jachymek, Harold J. Jennings, and Dennis L. Kasper

Rational chemical design of the carbohydrate in a glycoconjugate vaccine enhances IgM-to-IgG switching
PNAS 2008 105: 5903-5908; published online on March 31, 2008, 10.1073/pnas.0710799105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Neuroscience

Christian F. Doeller and Neil Burgess

Distinct error-correcting and incidental learning of location relative to landmarks and boundaries
PNAS 2008 105: 5909-5914; published online on April 14, 2008, 10.1073/pnas.0711433105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Christian F. Doeller, John A. King, and Neil Burgess

Parallel striatal and hippocampal systems for landmarks and boundaries in spatial memory
PNAS 2008 105: 5915-5920; published online on April 11, 2008, 10.1073/pnas.0801489105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Zaheer A. Rana, Kristian Gundersen, and Andres Buonanno

Activity-dependent repression of muscle genes by NFAT
PNAS 2008 105: 5921-5926; published online on April 11, 2008, 10.1073/pnas.0801330105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Plant Biology

Jae Sook Kang, Julia Frank, Chang Ho Kang, Hiroyuki Kajiura, Meenu Vikram, Akihiro Ueda, Sewon Kim, Jeong Dong Bahk, Barbara Triplett, Kazuhito Fujiyama, Sang Yeol Lee, Antje von Schaewen, and Hisashi Koiwa

Salt tolerance of Arabidopsis thaliana requires maturation of N-glycosylated proteins in the Golgi apparatus
PNAS 2008 105: 5933-5938; published online on April 11, 2008, 10.1073/pnas.0800237105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Psychology

Josh H. McDermott and Andrew J. Oxenham

Spectral completion of partially masked sounds
PNAS 2008 105: 5939-5944; published online on April 7, 2008, 10.1073/pnas.0711291105 [Abstract] [Full Text] [Figures Only] [PDF]  

CORRECTIONS

Correction for Zhang et al., Anyonic braiding in optical lattices [Full Text] [PDF]  

Correction for Barbano et al., A mathematical tool for exploring the dynamics of biological networks [Full Text] [PDF]