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THIS WEEK IN PNAS

In This Issue
PNAS 2008 105: 4531-4532. [Full Text] [PDF]  

LETTERS (Online only)

Michael Worobey, Arthur E. Pitchenik, M. Thomas P. Gilbert, Gabriela Wlasiuk, and Andrew Rambaut

Reply to Pape et al.: The phylogeography of HIV-1 group M subtype B
PNAS 2008 105: E16; published online on March 12, 2008, 10.1073/pnas.0712128105 [Extract] [Full Text] [PDF]  

COMMENTARIES

Michael R. Gryk and Jeffrey C. Hoch

Local knowledge helps determine protein structures
PNAS 2008 105: 4533-4534; published online on March 19, 2008, 10.1073/pnas.0801069105 [Extract] [Full Text] [Figures Only] [PDF]  
See companion article on page 4685

James B. Kaper and Mohamed A. Karmali

The continuing evolution of a bacterial pathogen
PNAS 2008 105: 4535-4536; published online on March 19, 2008, 10.1073/pnas.0801435105 [Extract] [Full Text] [PDF]  
See companion article on page 4868

Marcelle Holsters

SYMRK, an enigmatic receptor guarding and guiding microbial endosymbioses with plant roots
PNAS 2008 105: 4537-4538; published online on March 18, 2008, 10.1073/pnas.0801270105 [Extract] [Full Text] [Figures Only] [PDF]  
See companion article on page 4928

SPECIAL FEATURE

Introductory Perspectives

Jerrold Meinwald and Thomas Eisner

Chemical Ecology Special Feature: Chemical ecology in retrospect and prospect
PNAS 2008 105: 4539-4540; published online on March 19, 2008, 10.1073/pnas.0800649105 [Extract] [Full Text] [PDF]  

Perspectives

T. Luke Simmons, R. Cameron Coates, Benjamin R. Clark, Niclas Engene, David Gonzalez, Eduardo Esquenazi, Pieter C. Dorrestein, and William H. Gerwick

Chemical Ecology Special Feature: Biosynthetic origin of natural products isolated from marine microorganism–invertebrate assemblages
PNAS 2008 105: 4587-4594; published online on February 4, 2008, 10.1073/pnas.0709851105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Michael A. Fischbach, Christopher T. Walsh, and Jon Clardy

Chemical Ecology Special Feature: The evolution of gene collectives: How natural selection drives chemical innovation
PNAS 2008 105: 4601-4608; published online on January 23, 2008, 10.1073/pnas.0709132105 [Abstract] [Full Text] [Figures Only] [PDF]  

Research Articles

Thomas Hartmann

Chemical Ecology Special Feature: The lost origin of chemical ecology in the late 19th century
PNAS 2008 105: 4541-4546; published online on January 24, 2008, 10.1073/pnas.0709231105 [Abstract] [Full Text] [PDF]  

A. R. Zangerl, M. C. Stanley, and M. R. Berenbaum

Chemical Ecology Special Feature: Selection for chemical trait remixing in an invasive weed after reassociation with a coevolved specialist
PNAS 2008 105: 4547-4552; published online on January 31, 2008, 10.1073/pnas.0710280105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Table]  

Toby J. A. Bruce, Michaela C. Matthes, Keith Chamberlain, Christine M. Woodcock, Abdul Mohib, Ben Webster, Lesley E. Smart, Michael A. Birkett, John A. Pickett, and Johnathan A. Napier

Chemical Ecology Special Feature: cis-Jasmone induces Arabidopsis genes that affect the chemical ecology of multitrophic interactions with aphids and their parasitoids
PNAS 2008 105: 4553-4558; published online on March 20, 2008, 10.1073/pnas.0710305105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Shree P. Pandey, Priyanka Shahi, Klaus Gase, and Ian T. Baldwin

Chemical Ecology Special Feature: Herbivory-induced changes in the small-RNA transcriptome and phytohormone signaling in Nicotiana attenuata
PNAS 2008 105: 4559-4564; published online on March 13, 2008, 10.1073/pnas.0711363105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Joaquín Goyret, Poppy M. Markwell, and Robert A. Raguso

Chemical Ecology Special Feature: Context- and scale-dependent effects of floral CO₂ on nectar foraging by Manduca sexta
PNAS 2008 105: 4565-4570; published online on January 22, 2008, 10.1073/pnas.0708629105 [Abstract] [Full Text] [Figures Only] [PDF]  

Elsa Youngsteadt, Satoshi Nojima, Christopher Häberlein, Stefan Schulz, and Coby Schal

Chemical Ecology Special Feature: Seed odor mediates an obligate ant–plant mutualism in Amazonian rainforests
PNAS 2008 105: 4571-4575; published online on January 22, 2008, 10.1073/pnas.0708643105 [Abstract] [Full Text] [Figures Only] [PDF]  

Gabrielle A. Nevitt, Marcel Losekoot, and Henri Weimerskirch

From the Cover: Chemical Ecology Special Feature: Evidence for olfactory search in wandering albatross, Diomedea exulans
PNAS 2008 105: 4576-4581; published online on March 6, 2008, 10.1073/pnas.0709047105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Ernesto Mollo, Margherita Gavagnin, Marianna Carbone, Francesco Castelluccio, Ferdinando Pozone, Vassilios Roussis, José Templado, Michael T. Ghiselin, and Guido Cimino

Chemical Ecology Special Feature: Factors promoting marine invasions: A chemoecological approach
PNAS 2008 105: 4582-4586; published online on March 12, 2008, 10.1073/pnas.0709355105 [Abstract] [Full Text] [Figures Only] [PDF]  

Christian P. Ridley, Ho Young Lee, and Chaitan Khosla

Chemical Ecology Special Feature: Evolution of polyketide synthases in bacteria
PNAS 2008 105: 4595-4600; published online on February 4, 2008, 10.1073/pnas.0710107105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

PHYSICAL SCIENCES

Applied Physical Sciences

Chemistry

Ernesto Mollo, Margherita Gavagnin, Marianna Carbone, Francesco Castelluccio, Ferdinando Pozone, Vassilios Roussis, José Templado, Michael T. Ghiselin, and Guido Cimino

Chemical Ecology Special Feature: Factors promoting marine invasions: A chemoecological approach
PNAS 2008 105: 4582-4586; published online on March 12, 2008, 10.1073/pnas.0709355105 [Abstract] [Full Text] [Figures Only] [PDF]  

Jie Hu, Ao Ma, and Aaron R. Dinner

A two-step nucleotide-flipping mechanism enables kinetic discrimination of DNA lesions by AGT
PNAS 2008 105: 4615-4620; published online on March 19, 2008, 10.1073/pnas.0708058105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

W. Trent Franks, Benjamin J. Wylie, Heather L. Frericks Schmidt, Andrew J. Nieuwkoop, Rebecca-Maria Mayrhofer, Gautam J. Shah, Daniel T. Graesser, and Chad M. Rienstra

Dipole tensor-based atomic-resolution structure determination of a nanocrystalline protein by solid-state NMR
PNAS 2008 105: 4621-4626; published online on March 14, 2008, 10.1073/pnas.0712393105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Marcel O. Vlad, Alexandru Dan Corlan, Federico Morán, Peter Oefner, and John Ross

Incremental parameter evaluation from incomplete data with application to the population pharmacology of anticoagulants
PNAS 2008 105: 4627-4632; published online on March 19, 2008, 10.1073/pnas.0711508105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Computer Sciences

SOCIAL SCIENCES

Environmental Sciences

Social Sciences

BIOLOGICAL SCIENCES

Anthropology

Timothy D. Weaver, Charles C. Roseman, and Chris B. Stringer

Close correspondence between quantitative- and molecular-genetic divergence times for Neandertals and modern humans
PNAS 2008 105: 4645-4649; published online on March 17, 2008, 10.1073/pnas.0709079105 [Abstract] [Full Text] [Figures Only] [PDF]  

Adam D. Gordon, Lisa Nevell, and Bernard Wood

The Homo floresiensis cranium (LB1): Size, scaling, and early Homo affinities
PNAS 2008 105: 4650-4655; published online on March 20, 2008, 10.1073/pnas.0710041105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Applied Biological Sciences

Lucila Garcia-Contreras, Yun-Ling Wong, Pavan Muttil, Danielle Padilla, Jerry Sadoff, Jessica DeRousse, Willem Andreas Germishuizen, Sunali Goonesekera, Katharina Elbert, Barry R. Bloom, Rich Miller, P. Bernard Fourie, Anthony Hickey, and David Edwards

Immunization by a bacterial aerosol
PNAS 2008 105: 4656-4660; published online on March 14, 2008, 10.1073/pnas.0800043105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Appendix]  

Biochemistry

Wei Li, Ty E. Adams, Jyoti Nangalia, Charles T. Esmon, and James A. Huntington

Molecular basis of thrombin recognition by protein C inhibitor revealed by the 1.6-Å structure of the heparin-bridged complex
PNAS 2008 105: 4661-4666; published online on March 24, 2008, 10.1073/pnas.0711055105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Hervé Roy and Michael Ibba

RNA-dependent lipid remodeling by bacterial multiple peptide resistance factors
PNAS 2008 105: 4667-4672; published online on February 27, 2008, 10.1073/pnas.0800006105 [Abstract] [Full Text] [Figures Only] [PDF]  

Robin N. Evans, Gregor Blaha, Scott Bailey, and Thomas A. Steitz The structure of LepA, the ribosomal back translocase PNAS 2008 105: 4673-4678; published online on March 24, 2008, 10.1073/pnas.0801308105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information] OPEN ACCESS ARTICLE

Biophysics

Jie Hu, Ao Ma, and Aaron R. Dinner

A two-step nucleotide-flipping mechanism enables kinetic discrimination of DNA lesions by AGT
PNAS 2008 105: 4615-4620; published online on March 19, 2008, 10.1073/pnas.0708058105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

W. Trent Franks, Benjamin J. Wylie, Heather L. Frericks Schmidt, Andrew J. Nieuwkoop, Rebecca-Maria Mayrhofer, Gautam J. Shah, Daniel T. Graesser, and Chad M. Rienstra

Dipole tensor-based atomic-resolution structure determination of a nanocrystalline protein by solid-state NMR
PNAS 2008 105: 4621-4626; published online on March 14, 2008, 10.1073/pnas.0712393105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Celestine N. Chi, Lisa Elfström, Yao Shi, Tord Snäll, Åke Engström, and Per Jemth

Reassessing a sparse energetic network within a single protein domain
PNAS 2008 105: 4679-4684; published online on March 13, 2008, 10.1073/pnas.0711732105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Yang Shen, Oliver Lange, Frank Delaglio, Paolo Rossi, James M. Aramini, Gaohua Liu, Alexander Eletsky, Yibing Wu, Kiran K. Singarapu, Alexander Lemak, Alexandr Ignatchenko, Cheryl H. Arrowsmith, Thomas Szyperski, Gaetano T. Montelione, David Baker, and Ad Bax From the Cover: Consistent blind protein structure generation from NMR chemical shift data PNAS 2008 105: 4685-4690; published online on March 7, 2008, 10.1073/pnas.0800256105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]   See Commentary on page 4533

M. Yusuf Ali, Hailong Lu, Carol S. Bookwalter, David M. Warshaw, and Kathleen M. Trybus

Myosin V and Kinesin act as tethers to enhance each others' processivity
PNAS 2008 105: 4691-4696; published online on March 17, 2008, 10.1073/pnas.0711531105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Jeanne C. Stachowiak, David L. Richmond, Thomas H. Li, Allen P. Liu, Sapun H. Parekh, and Daniel A. Fletcher

Unilamellar vesicle formation and encapsulation by microfluidic jetting
PNAS 2008 105: 4697-4702; published online on March 19, 2008, 10.1073/pnas.0710875105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Deborah F. Kelly, Danijela Dukovski, and Thomas Walz

Monolayer purification: A rapid method for isolating protein complexes for single-particle electron microscopy
PNAS 2008 105: 4703-4708; published online on March 17, 2008, 10.1073/pnas.0800867105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Cell Biology

Yin Shen, Youko Matsuno, Shaun D. Fouse, Nagesh Rao, Sierra Root, Renhe Xu, Matteo Pellegrini, Arthur D. Riggs, and Guoping Fan

X-inactivation in female human embryonic stem cells is in a nonrandom pattern and prone to epigenetic alterations
PNAS 2008 105: 4709-4714; published online on March 13, 2008, 10.1073/pnas.0712018105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Ludivine Sinzelle, Vladimir V. Kapitonov, Dawid P. Grzela, Tobias Jursch, Jerzy Jurka, Zsuzsanna Izsvák, and Zoltán Ivics

Transposition of a reconstructed Harbinger element in human cells and functional homology with two transposon-derived cellular genes
PNAS 2008 105: 4715-4720; published online on March 13, 2008, 10.1073/pnas.0707746105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Zoltan Arany, Bridget K. Wagner, Yanhong Ma, Jessica Chinsomboon, Dina Laznik, and Bruce M. Spiegelman

Gene expression-based screening identifies microtubule inhibitors as inducers of PGC-1 and oxidative phosphorylation
PNAS 2008 105: 4721-4726; published online on March 17, 2008, 10.1073/pnas.0800979105 [Abstract] [Full Text] [Figures Only] [PDF]  

Maud Martin, Michael Potente, Veerle Janssens, Didier Vertommen, Jean-Claude Twizere, Mark H. Rider, Jozef Goris, Stefanie Dimmeler, Richard Kettmann, and Franck Dequiedt

Protein phosphatase 2A controls the activity of histone deacetylase 7 during T cell apoptosis and angiogenesis
PNAS 2008 105: 4727-4732; published online on March 13, 2008, 10.1073/pnas.0708455105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Brian T. Baranick, Nathan A. Lemp, Jill Nagashima, Kei Hiraoka, Noriyuki Kasahara, and Christopher R. Logg Splicing mediates the activity of four putative cellular internal ribosome entry sites PNAS 2008 105: 4733-4738; published online on March 7, 2008, 10.1073/pnas.0710650105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information] OPEN ACCESS ARTICLE

Yonghui Jia, Fabien Loison, Hidenori Hattori, Yitang Li, Christophe Erneux, Shin-Young Park, Chong Gao, Li Chai, Leslie E. Silberstein, Stephane Schurmans, and Hongbo R. Luo

Inositol trisphosphate 3-kinase B (InsP3KB) as a physiological modulator of myelopoiesis
PNAS 2008 105: 4739-4744; published online on March 13, 2008, 10.1073/pnas.0800218105 [Abstract] [Full Text] [Figures Only] [PDF]  

Amandine Ginouvès, Karine Ilc, Nuria Macías, Jacques Pouysségur, and Edurne Berra

PHDs overactivation during chronic hypoxia "desensitizes" HIF and protects cells from necrosis
PNAS 2008 105: 4745-4750; published online on March 17, 2008, 10.1073/pnas.0705680105 [Abstract] [Full Text] [Figures Only] [PDF]  

Jenny Presto, Maria Thuveson, Pernilla Carlsson, Marta Busse, Maria Wilén, Inger Eriksson, Marion Kusche-Gullberg, and Lena Kjellén

Heparan sulfate biosynthesis enzymes EXT1 and EXT2 affect NDST1 expression and heparan sulfate sulfation
PNAS 2008 105: 4751-4756; published online on March 12, 2008, 10.1073/pnas.0705807105 [Abstract] [Full Text] [Figures Only] [PDF]  

Qiuming Kan, Shigeki Jinno, Hanako Yamamoto, Kohei Kobayashi, and Hiroto Okayama

ATP-dependent activation of p21^WAF1/CIP1-associated Cdk2 by Cdc6
PNAS 2008 105: 4757-4762; published online on March 20, 2008, 10.1073/pnas.0706392105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Developmental Biology

Ecology

Thomas Hartmann

Chemical Ecology Special Feature: The lost origin of chemical ecology in the late 19th century
PNAS 2008 105: 4541-4546; published online on January 24, 2008, 10.1073/pnas.0709231105 [Abstract] [Full Text] [PDF]  

Shree P. Pandey, Priyanka Shahi, Klaus Gase, and Ian T. Baldwin

Chemical Ecology Special Feature: Herbivory-induced changes in the small-RNA transcriptome and phytohormone signaling in Nicotiana attenuata
PNAS 2008 105: 4559-4564; published online on March 13, 2008, 10.1073/pnas.0711363105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Joaquín Goyret, Poppy M. Markwell, and Robert A. Raguso

Chemical Ecology Special Feature: Context- and scale-dependent effects of floral CO₂ on nectar foraging by Manduca sexta
PNAS 2008 105: 4565-4570; published online on January 22, 2008, 10.1073/pnas.0708629105 [Abstract] [Full Text] [Figures Only] [PDF]  

Elsa Youngsteadt, Satoshi Nojima, Christopher Häberlein, Stefan Schulz, and Coby Schal

Chemical Ecology Special Feature: Seed odor mediates an obligate ant–plant mutualism in Amazonian rainforests
PNAS 2008 105: 4571-4575; published online on January 22, 2008, 10.1073/pnas.0708643105 [Abstract] [Full Text] [Figures Only] [PDF]  

Gabrielle A. Nevitt, Marcel Losekoot, and Henri Weimerskirch

From the Cover: Chemical Ecology Special Feature: Evidence for olfactory search in wandering albatross, Diomedea exulans
PNAS 2008 105: 4576-4581; published online on March 6, 2008, 10.1073/pnas.0709047105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Ernesto Mollo, Margherita Gavagnin, Marianna Carbone, Francesco Castelluccio, Ferdinando Pozone, Vassilios Roussis, José Templado, Michael T. Ghiselin, and Guido Cimino

Chemical Ecology Special Feature: Factors promoting marine invasions: A chemoecological approach
PNAS 2008 105: 4582-4586; published online on March 12, 2008, 10.1073/pnas.0709355105 [Abstract] [Full Text] [Figures Only] [PDF]  

Christian P. Ridley, Ho Young Lee, and Chaitan Khosla

Chemical Ecology Special Feature: Evolution of polyketide synthases in bacteria
PNAS 2008 105: 4595-4600; published online on February 4, 2008, 10.1073/pnas.0710107105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Marius Gilbert, Xiangming Xiao, Dirk U. Pfeiffer, M. Epprecht, Stephen Boles, Christina Czarnecki, Prasit Chaitaweesub, Wantanee Kalpravidh, Phan Q. Minh, M. J. Otte, Vincent Martin, and Jan Slingenbergh Mapping H5N1 highly pathogenic avian influenza risk in Southeast Asia PNAS 2008 105: 4769-4774; published online on March 24, 2008, 10.1073/pnas.0710581105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information] OPEN ACCESS ARTICLE

Environmental Sciences

Evolution

A. R. Zangerl, M. C. Stanley, and M. R. Berenbaum

Chemical Ecology Special Feature: Selection for chemical trait remixing in an invasive weed after reassociation with a coevolved specialist
PNAS 2008 105: 4547-4552; published online on January 31, 2008, 10.1073/pnas.0710280105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Table]  

Christopher J. Tonkin, Bernardo J. Foth, Stuart A. Ralph, Nicole Struck, Alan F. Cowman, and Geoffrey I. McFadden

Evolution of malaria parasite plastid targeting sequences
PNAS 2008 105: 4781-4785; published online on March 19, 2008, 10.1073/pnas.0707827105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Sarah J. Adamowicz, Andy Purvis, and Matthew A. Wills

Increasing morphological complexity in multiple parallel lineages of the Crustacea
PNAS 2008 105: 4786-4791; published online on March 17, 2008, 10.1073/pnas.0709378105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Anthony Herrel, Katleen Huyghe, Bieke Vanhooydonck, Thierry Backeljau, Karin Breugelmans, Irena Grbac, Raoul Van Damme, and Duncan J. Irschick

Rapid large-scale evolutionary divergence in morphology and performance associated with exploitation of a different dietary resource
PNAS 2008 105: 4792-4795; published online on March 14, 2008, 10.1073/pnas.0711998105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Figure]  

Immunology

Anupama Ahuja, Shannon M. Anderson, Ashraf Khalil, and Mark J. Shlomchik

Maintenance of the plasma cell pool is independent of memory B cells
PNAS 2008 105: 4802-4807; published online on March 13, 2008, 10.1073/pnas.0800555105 [Abstract] [Full Text] [Figures Only] [PDF]  

Surinder Kaur, Antonella Sassano, Blazej Dolniak, Sonali Joshi, Beata Majchrzak-Kita, Darren P. Baker, Nissim Hay, Eleanor N. Fish, and Leonidas C. Platanias

Role of the Akt pathway in mRNA translation of interferon-stimulated genes
PNAS 2008 105: 4808-4813; published online on March 13, 2008, 10.1073/pnas.0710907105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Gabriele S. V. Campanella, Andrew M. Tager, Joseph K. El Khoury, Seddon Y. Thomas, Tabitha A. Abrazinski, Lindsay A. Manice, Richard A. Colvin, and Andrew D. Luster

Chemokine receptor CXCR3 and its ligands CXCL9 and CXCL10 are required for the development of murine cerebral malaria
PNAS 2008 105: 4814-4819; published online on March 17, 2008, 10.1073/pnas.0801544105 [Abstract] [Full Text] [Figures Only] [PDF]  

Medical Sciences

Marcel O. Vlad, Alexandru Dan Corlan, Federico Morán, Peter Oefner, and John Ross

Incremental parameter evaluation from incomplete data with application to the population pharmacology of anticoagulants
PNAS 2008 105: 4627-4632; published online on March 19, 2008, 10.1073/pnas.0711508105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Susana S. Silva, Rebecca K. Rowntree, Shila Mekhoubad, and Jeannie T. Lee

X-chromosome inactivation and epigenetic fluidity in human embryonic stem cells
PNAS 2008 105: 4820-4825; published online on March 13, 2008, 10.1073/pnas.0712136105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Lan Wang, Guang-Biao Zhou, Ping Liu, Jun-Hong Song, Yang Liang, Xiao-Jing Yan, Fang Xu, Bing-Shun Wang, Jian-Hua Mao, Zhi-Xiang Shen, Sai-Juan Chen, and Zhu Chen

Dissection of mechanisms of Chinese medicinal formula Realgar-Indigo naturalis as an effective treatment for promyelocytic leukemia
PNAS 2008 105: 4826-4831; published online on March 14, 2008, 10.1073/pnas.0712365105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Ahmad R. Sedaghat, Jason B. Dinoso, Lin Shen, Claus O. Wilke, and Robert F. Siliciano

Decay dynamics of HIV-1 depend on the inhibited stages of the viral life cycle
PNAS 2008 105: 4832-4837; published online on March 24, 2008, 10.1073/pnas.0711372105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Yoshinori Abe, Eri Oda-Sato, Kei Tobiume, Keiko Kawauchi, Yoichi Taya, Koji Okamoto, Moshe Oren, and Nobuyuki Tanaka

Hedgehog signaling overrides p53-mediated tumor suppression by activating Mdm2
PNAS 2008 105: 4838-4843; published online on March 21, 2008, 10.1073/pnas.0712216105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Mathias Ehrich, Julia Turner, Peter Gibbs, Lara Lipton, Mara Giovanneti, Charles Cantor, and Dirk van den Boom Cytosine methylation profiling of cancer cell lines PNAS 2008 105: 4844-4849; published online on March 19, 2008, 10.1073/pnas.0712251105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information] OPEN ACCESS ARTICLE

Julien Fitamant, Céline Guenebeaud, Marie-May Coissieux, Catherine Guix, Isabelle Treilleux, Jean-Yves Scoazec, Thomas Bachelot, Agnès Bernet, and Patrick Mehlen

Netrin-1 expression confers a selective advantage for tumor cell survival in metastatic breast cancer
PNAS 2008 105: 4850-4855; published online on March 19, 2008, 10.1073/pnas.0709810105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Joseph F. Arboleda-Velasquez, Zhipeng Zhou, Hwa Kyoung Shin, Angeliki Louvi, Hyung-Hwan Kim, Sean I. Savitz, James K. Liao, Salvatore Salomone, Cenk Ayata, Michael A. Moskowitz, and Spyros Artavanis-Tsakonas

Linking Notch signaling to ischemic stroke
PNAS 2008 105: 4856-4861; published online on March 17, 2008, 10.1073/pnas.0709867105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Appendix]  

Freddy Jeanneteau, Michael J. Garabedian, and Moses V. Chao

Activation of Trk neurotrophin receptors by glucocorticoids provides a neuroprotective effect
PNAS 2008 105: 4862-4867; published online on March 17, 2008, 10.1073/pnas.0709102105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Microbiology

Rays H. Y. Jiang, Sucheta Tripathy, Francine Govers, and Brett M. Tyler

RXLR effector reservoir in two Phytophthora species is dominated by a single rapidly evolving superfamily with more than 700 members
PNAS 2008 105: 4874-4879; published online on March 14, 2008, 10.1073/pnas.0709303105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Van Q. Nguyen and Anita Sil

Temperature-induced switch to the pathogenic yeast form of Histoplasma capsulatum requires Ryp1, a conserved transcriptional regulator
PNAS 2008 105: 4880-4885; published online on March 13, 2008, 10.1073/pnas.0710448105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Jennifer Baysarowich, Kalinka Koteva, Donald W. Hughes, Linda Ejim, Emma Griffiths, Kun Zhang, Murray Junop, and Gerard D. Wright

Rifamycin antibiotic resistance by ADP-ribosylation: Structure and diversity of Arr
PNAS 2008 105: 4886-4891; published online on March 18, 2008, 10.1073/pnas.0711939105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Appendix]  

Neuroscience

Takahiro Miyawaki, Toshihiro Mashiko, Dimitry Ofengeim, Richard J. Flannery, Kyung-Min Noh, Sho Fujisawa, Laura Bonanni, Michael V. L. Bennett, R. Suzanne Zukin, and Elizabeth A. Jonas

Ischemic preconditioning blocks BAD translocation, Bcl-x_L cleavage, and large channel activity in mitochondria of postischemic hippocampal neurons
PNAS 2008 105: 4892-4897; published online on March 17, 2008, 10.1073/pnas.0800628105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

M. M. C. Gonzalez and G. Aston-Jones

Light deprivation damages monoamine neurons and produces a depressive behavioral phenotype in rats
PNAS 2008 105: 4898-4903; published online on March 17, 2008, 10.1073/pnas.0703615105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Marie Vandecasteele, Jacques Glowinski, Jean-Michel Deniau, and Laurent Venance

Chemical transmission between dopaminergic neuron pairs
PNAS 2008 105: 4904-4909; published online on March 17, 2008, 10.1073/pnas.0703121105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Satoko Yamaguchi, Reinhard Wolf, Claude Desplan, and Martin Heisenberg

Motion vision is independent of color in Drosophila
PNAS 2008 105: 4910-4915; published online on March 19, 2008, 10.1073/pnas.0711484105 [Abstract] [Full Text] [Figures Only] [PDF] [Supporting Information]  

Fred L. Robinson, Ingrid R. Niesman, Kristina K. Beiswenger, and Jack E. Dixon

Loss of the inactive myotubularin-related phosphatase Mtmr13 leads to a Charcot–Marie–Tooth 4B2-like peripheral neuropathy in mice<