This Week in PNAS

Commentary

  • Commentary:
    • Curtis C. Harris

    Protein–protein interactions for cancer therapy

    PNAS 2006 103:1659-1660; published ahead of print February 1, 2006, doi:10.1073/pnas.0510948103
    • See companion article on page 1888 in issue 6 of volume 103

Perspective

Profiles

  • Profile:
    • Nick Zagorski

    Profile of Alan M. Lambowitz

    PNAS 2006 103:1669-1671; published ahead of print January 31, 2006, doi:10.1073/pnas.0508183103
    • See commentary article on page 45 in issue 1 of volume 102
  • Profile:
    • Regina Nuzzo

    Profile of George Oster

    PNAS 2006 103:1672-1674; published ahead of print January 30, 2006, doi:10.1073/pnas.0509056103
    • See commentary article on page 16539 in issue 46 of volume 102

Physical Sciences

Applied Mathematics

  • Physical Sciences - Applied Mathematics - Biological Sciences - Physiology:
    • J. Sneyd,
    • K. Tsaneva-Atanasova,
    • V. Reznikov,
    • Y. Bai,
    • M. J. Sanderson,
    • and D. I. Yule

    A method for determining the dependence of calcium oscillations on inositol trisphosphate oscillations

    PNAS 2006 103:1675-1680; published ahead of print January 30, 2006, doi:10.1073/pnas.0506135103
  • Physical Sciences - Applied Mathematics - Biological Sciences - Biophysics:
    • Daniel A. Koster,
    • Chris H. Wiggins,
    • and Nynke H. Dekker

    Multiple events on single molecules: Unbiased estimation in single-molecule biophysics

    PNAS 2006 103:1750-1755; published ahead of print January 26, 2006, doi:10.1073/pnas.0510509103

Chemistry

  • Physical Sciences - Chemistry - Biological Sciences - Biochemistry:
    • Dimitra K. Georgiou
    • and Peter G. Vekilov

    A fast response mechanism for insulin storage in crystals may involve kink generation by association of 2D clusters

    PNAS 2006 103:1681-1686; published ahead of print January 30, 2006, doi:10.1073/pnas.0506526103

Geology

  • Physical Sciences - Geology - Biological Sciences - Evolution:
    • Geerat J. Vermeij

    Historical contingency and the purported uniqueness of evolutionary innovations

    PNAS 2006 103:1804-1809; published ahead of print January 27, 2006, doi:10.1073/pnas.0508724103

Biological Sciences

Agricultural Sciences

  • Biological Sciences - Agricultural Sciences:
    • Andrew C. Brown,
    • Susan J. Baigent,
    • Lorraine P. Smith,
    • Jason P. Chattoo,
    • Lawrence J. Petherbridge,
    • Pippa Hawes,
    • Martin J. Allday,
    • and Venugopal Nair

    Interaction of MEQ protein and C-terminal-binding protein is critical for induction of lymphomas by Marek’s disease virus

    PNAS 2006 103:1687-1692; published ahead of print January 30, 2006, doi:10.1073/pnas.0507595103

Applied Biological Sciences

  • Biological Sciences - Applied Biological Sciences:
    • Stephan van Sint Fiet,
    • Jan B. van Beilen,
    • and Bernard Witholt

    Selection of biocatalysts for chemical synthesis

    PNAS 2006 103:1693-1698; published ahead of print January 30, 2006, doi:10.1073/pnas.0504733102
  • Biological Sciences - Applied Biological Sciences:
    • Tolunay Beker Aydemir,
    • Raymond K. Blanchard,
    • and Robert J. Cousins

    Zinc supplementation of young men alters metallothionein, zinc transporter, and cytokine gene expression in leukocyte populations

    PNAS 2006 103:1699-1704; published ahead of print January 24, 2006, doi:10.1073/pnas.0510407103

Biochemistry

  • Physical Sciences - Chemistry - Biological Sciences - Biochemistry:
    • Dimitra K. Georgiou
    • and Peter G. Vekilov

    A fast response mechanism for insulin storage in crystals may involve kink generation by association of 2D clusters

    PNAS 2006 103:1681-1686; published ahead of print January 30, 2006, doi:10.1073/pnas.0506526103
  • Biological Sciences - Biochemistry:
    • Alejandro Buschiazzo,
    • Maira Goytia,
    • Francis Schaeffer,
    • Wim Degrave,
    • William Shepard,
    • Christophe Grégoire,
    • Nathalie Chamond,
    • Alain Cosson,
    • Armand Berneman,
    • Nicolas Coatnoan,
    • Pedro M. Alzari,
    • and Paola Minoprio

    Crystal structure, catalytic mechanism, and mitogenic properties of Trypanosoma cruzi proline racemase

    PNAS 2006 103:1705-1710; published ahead of print January 30, 2006, doi:10.1073/pnas.0509010103
  • Biological Sciences - Biochemistry:
    • Hui Zhu,
    • Jayakrishnan Nandakumar,
    • Jideofor Aniukwu,
    • Li Kai Wang,
    • Michael S. Glickman,
    • Christopher D. Lima,
    • and Stewart Shuman

    Atomic structure and nonhomologous end-joining function of the polymerase component of bacterial DNA ligase D

    PNAS 2006 103:1711-1716; published ahead of print January 30, 2006, doi:10.1073/pnas.0509083103
  • Biological Sciences - Biochemistry:
    • Ewen Gallagher,
    • Min Gao,
    • Yun-Cai Liu,
    • and Michael Karin

    Activation of the E3 ubiquitin ligase Itch through a phosphorylation-induced conformational change

    PNAS 2006 103:1717-1722; published ahead of print January 30, 2006, doi:10.1073/pnas.0510664103
  • Biological Sciences - Biochemistry:
    • Lan Guan,
    • Irina N. Smirnova,
    • Gill Verner,
    • Shushi Nagamori,
    • and H. Ronald Kaback

    Manipulating phospholipids for crystallization of a membrane transport protein

    PNAS 2006 103:1723-1726; published ahead of print January 30, 2006, doi:10.1073/pnas.0510922103
  • Biological Sciences - Biochemistry:
    • Noriyuki Miyoshi,
    • Hammou Oubrahim,
    • P. Boon Chock,
    • and Earl R. Stadtman

    Age-dependent cell death and the role of ATP in hydrogen peroxide-induced apoptosis and necrosis

    PNAS 2006 103:1727-1731; published ahead of print January 27, 2006, doi:10.1073/pnas.0510346103
    Open Access Article

Biophysics

  • Biological Sciences - Biophysics:
    • Jin Kwang Kim,
    • In Seok Yang,
    • Hye Jeong Shin,
    • Ki Joon Cho,
    • Eui Kyung Ryu,
    • Sun Hwa Kim,
    • Sung Soo Park,
    • and Kyung Hyun Kim

    Insight into autoproteolytic activation from the structure of cephalosporin acylase: A protein with two proteolytic chemistries

    PNAS 2006 103:1732-1737; published ahead of print January 30, 2006, doi:10.1073/pnas.0507862103
  • Biological Sciences - Biophysics:
    • D. Flemming Hansen
    • and Jens J. Led

    Determination of the geometric structure of the metal site in a blue copper protein by paramagnetic NMR

    PNAS 2006 103:1738-1743; published ahead of print January 30, 2006, doi:10.1073/pnas.0507179103
  • Biological Sciences - Biophysics:
    • Joanna Makowska,
    • Sylwia Rodziewicz-Motowidło,
    • Katarzyna Bagińska,
    • Jorge A. Vila,
    • Adam Liwo,
    • Lech Chmurzyński,
    • and Harold A. Scheraga

    Polyproline II conformation is one of many local conformational states and is not an overall conformation of unfolded peptides and proteins

    PNAS 2006 103:1744-1749; published ahead of print January 30, 2006, doi:10.1073/pnas.0510549103
  • Physical Sciences - Applied Mathematics - Biological Sciences - Biophysics:
    • Daniel A. Koster,
    • Chris H. Wiggins,
    • and Nynke H. Dekker

    Multiple events on single molecules: Unbiased estimation in single-molecule biophysics

    PNAS 2006 103:1750-1755; published ahead of print January 26, 2006, doi:10.1073/pnas.0510509103
  • Biological Sciences - Biophysics:
    • Michael Habeck,
    • Wolfgang Rieping,
    • and Michael Nilges

    Weighting of experimental evidence in macromolecular structure determination

    PNAS 2006 103:1756-1761; published ahead of print January 30, 2006, doi:10.1073/pnas.0506412103
  • Biological Sciences - Biophysics:
    • M. L. Gardel,
    • F. Nakamura,
    • J. H. Hartwig,
    • J. C. Crocker,
    • T. P. Stossel,
    • and D. A. Weitz

    Prestressed F-actin networks cross-linked by hinged filamins replicate mechanical properties of cells

    PNAS 2006 103:1762-1767; published ahead of print January 30, 2006, doi:10.1073/pnas.0504777103

Cell Biology

  • Biological Sciences - Cell Biology:
    • G. López-Lluch,
    • N. Hunt,
    • B. Jones,
    • M. Zhu,
    • H. Jamieson,
    • S. Hilmer,
    • M. V. Cascajo,
    • J. Allard,
    • D. K. Ingram,
    • P. Navas,
    • and R. de Cabo

    Calorie restriction induces mitochondrial biogenesis and bioenergetic efficiency

    PNAS 2006 103:1768-1773; published ahead of print January 30, 2006, doi:10.1073/pnas.0510452103
    Open Access Article
  • Biological Sciences - Cell Biology:
    • Yingxiao Wang,
    • Gang Jin,
    • Hui Miao,
    • Julie Y.-S. Li,
    • Shunichi Usami,
    • and Shu Chien

    Integrins regulate VE-cadherin and catenins: Dependence of this regulation on Src, but not on Ras

    PNAS 2006 103:1774-1779; published ahead of print January 30, 2006, doi:10.1073/pnas.0510774103
  • Biological Sciences - Cell Biology:
    • Fumihiko Furuya,
    • John A. Hanover,
    • and Sheue-yann Cheng

    Activation of phosphatidylinositol 3-kinase signaling by a mutant thyroid hormone β receptor

    PNAS 2006 103:1780-1785; published ahead of print January 30, 2006, doi:10.1073/pnas.0510849103
  • Biological Sciences - Cell Biology:
    • Juan E. Keymer,
    • Robert G. Endres,
    • Monica Skoge,
    • Yigal Meir,
    • and Ned S. Wingreen

    Chemosensing in Escherichia coli : Two regimes of two-state receptors

    PNAS 2006 103:1786-1791; published ahead of print January 30, 2006, doi:10.1073/pnas.0507438103

Developmental Biology

  • Biological Sciences - Developmental Biology:
    • Shiro Iuchi,
    • Sally Dabelsteen,
    • Karen Easley,
    • James G. Rheinwald,
    • and Howard Green

    Immortalized keratinocyte lines derived from human embryonic stem cells

    PNAS 2006 103:1792-1797; published ahead of print January 30, 2006, doi:10.1073/pnas.0510953103

Evolution

  • Biological Sciences - Evolution:
    • Roy Britten

    Transposable elements have contributed to thousands of human proteins

    PNAS 2006 103:1798-1803; published ahead of print January 27, 2006, doi:10.1073/pnas.0510007103
  • Physical Sciences - Geology - Biological Sciences - Evolution:
    • Geerat J. Vermeij

    Historical contingency and the purported uniqueness of evolutionary innovations

    PNAS 2006 103:1804-1809; published ahead of print January 27, 2006, doi:10.1073/pnas.0508724103

Genetics

  • Biological Sciences - Genetics:
    • Jonathan C. Cohen,
    • Alexander Pertsemlidis,
    • Saleemah Fahmi,
    • Sophie Esmail,
    • Gloria L. Vega,
    • Scott M. Grundy,
    • and Helen H. Hobbs

    Multiple rare variants in NPC1L1 associated with reduced sterol absorption and plasma low-density lipoprotein levels

    PNAS 2006 103:1810-1815; published ahead of print January 31, 2006, doi:10.1073/pnas.0508483103
    Open Access Article
  • Biological Sciences - Genetics:
    • Soma Banerjee,
    • Stephanie Smith,
    • and Kyungjae Myung

    Suppression of gross chromosomal rearrangements by yKu70-yKu80 heterodimer through DNA damage checkpoints

    PNAS 2006 103:1816-1821; published ahead of print January 30, 2006, doi:10.1073/pnas.0504063102
    Open Access Article

Immunology

  • Biological Sciences - Immunology:
    • Qing Ge,
    • Phillip D. Holler,
    • Vinay S. Mahajan,
    • Tam Nuygen,
    • Herman N. Eisen,
    • and Jianzhu Chen

    Development of CD4 + T cells expressing a nominally MHC class I-restricted T cell receptor by two different mechanisms

    PNAS 2006 103:1822-1827; published ahead of print January 27, 2006, doi:10.1073/pnas.0510561103
  • Biological Sciences - Immunology:
    • Jongdae Lee,
    • Christina C. N. Wu,
    • Ki Jeong Lee,
    • Tsung-Hsien Chuang,
    • Kyoko Katakura,
    • Yu-Tsueng Liu,
    • Michael Chan,
    • Rommel Tawatao,
    • Michelle Chung,
    • Carol Shen,
    • Howard B. Cottam,
    • Michael M. C. Lai,
    • Eyal Raz,
    • and Dennis A. Carson

    Activation of anti-hepatitis C virus responses via Toll-like receptor 7

    PNAS 2006 103:1828-1833; published ahead of print January 30, 2006, doi:10.1073/pnas.0510801103
  • Biological Sciences - Immunology:
    • Thorsten Berger,
    • Atsushi Togawa,
    • Gordon S. Duncan,
    • Andrew J. Elia,
    • Annick You-Ten,
    • Andrew Wakeham,
    • Hannah E. H. Fong,
    • Carol C. Cheung,
    • and Tak W. Mak

    Lipocalin 2-deficient mice exhibit increased sensitivity to Escherichia coli infection but not to ischemia-reperfusion injury

    PNAS 2006 103:1834-1839; published ahead of print January 30, 2006, doi:10.1073/pnas.0510847103
    Open Access Article
  • Biological Sciences - Immunology:
    • Jean da Silva Correia,
    • Yvonne Miranda,
    • Nikki Austin-Brown,
    • Jenny Hsu,
    • John Mathison,
    • Rong Xiang,
    • Huamin Zhou,
    • Qinxi Li,
    • Jiahuai Han,
    • and Richard J. Ulevitch

    Nod1-dependent control of tumor growth

    PNAS 2006 103:1840-1845; published ahead of print January 30, 2006, doi:10.1073/pnas.0509228103
  • Biological Sciences - Immunology:
    • Helen Dooley,
    • Robyn L. Stanfield,
    • Rebecca A. Brady,
    • and Martin F. Flajnik

    First molecular and biochemical analysis of in vivo affinity maturation in an ectothermic vertebrate

    PNAS 2006 103:1846-1851; published ahead of print January 30, 2006, doi:10.1073/pnas.0508341103

Medical Sciences

  • Biological Sciences - Medical Sciences:
    • Yijen L. Wu,
    • Qing Ye,
    • Lesley M. Foley,
    • T. Kevin Hitchens,
    • Kazuya Sato,
    • John B. Williams,
    • and Chien Ho

    In situ labeling of immune cells with iron oxide particles: An approach to detect organ rejection by cellular MRI

    PNAS 2006 103:1852-1857; published ahead of print January 27, 2006, doi:10.1073/pnas.0507198103
  • Biological Sciences - Medical Sciences:
    • Chenzhong Kuang,
    • Yan Xiao,
    • Xubao Liu,
    • Teresa M. Stringfield,
    • Shaobo Zhang,
    • Zhenzhen Wang,
    • and Yan Chen

    In vivo disruption of TGF-β signaling by Smad7 leads to premalignant ductal lesions in the pancreas

    PNAS 2006 103:1858-1863; published ahead of print January 27, 2006, doi:10.1073/pnas.0508977103
  • Biological Sciences - Medical Sciences:
    • Vladimir Vartanian,
    • Brian Lowell,
    • Irina G. Minko,
    • Thomas G. Wood,
    • Jeffrey D. Ceci,
    • Shakeeta George,
    • Scott W. Ballinger,
    • Christopher L. Corless,
    • Amanda K. McCullough,
    • and R. Stephen Lloyd

    The metabolic syndrome resulting from a knockout of the NEIL1 DNA glycosylase

    PNAS 2006 103:1864-1869; published ahead of print January 30, 2006, doi:10.1073/pnas.0507444103
    Open Access Article
  • Biological Sciences - Medical Sciences:
    • Srinivasa Raju Mantena,
    • Athilakshmi Kannan,
    • Yong-Pil Cheon,
    • Quanxi Li,
    • Peter F. Johnson,
    • Indrani C. Bagchi,
    • and