This Week in PNAS

Commentaries

  • Commentary:
    • Cédric Feschotte

    The piggyBac transposon holds promise for human gene therapy

    PNAS 2006 103:14981-14982; published ahead of print October 2, 2006, doi:10.1073/pnas.0607282103
    • See companion article on page 15008 in issue 41 of volume 103
  • Commentary:
    • Tommaso Pizzari

    Of mice and sperm

    PNAS 2006 103:14983-14984; published ahead of print October 2, 2006, doi:10.1073/pnas.0607091103
    • See companion article on page 15113 in issue 41 of volume 103
  • Commentary:
    • Michael Leon
    • and Brett Johnson

    Functional units in the olfactory system

    PNAS 2006 103:14985-14986; published ahead of print October 2, 2006, doi:10.1073/pnas.0607416103
    • See companion article on page 15206 in issue 41 of volume 103

Physical Sciences

Chemistry

  • Physical Sciences - Chemistry - Biological Sciences - Biochemistry:
    • Anirban Banerjee
    • and Gregory L. Verdine

    A nucleobase lesion remodels the interaction of its normal neighbor in a DNA glycosylase complex

    PNAS 2006 103:15020-15025; published ahead of print October 2, 2006, doi:10.1073/pnas.0603644103

Physics

  • Biological Sciences - Biophysics - Physical Sciences - Physics:
    • Yaroslav Tserkovnyak
    • and David R. Nelson

    Conditions for extreme sensitivity of protein diffusion in membranes to cell environments

    PNAS 2006 103:15002-15007; published ahead of print September 28, 2006, doi:10.1073/pnas.0606992103

Biological Sciences

Applied Biological Sciences

  • Biological Sciences - Applied Biological Sciences:
    • Sareina Chiung-Yuan Wu,
    • Yaa-Jyuhn James Meir,
    • Craig J. Coates,
    • Alfred M. Handler,
    • Pawel Pelczar,
    • Stefan Moisyadi,
    • and Joseph M. Kaminski

    From the Cover: piggyBac is a flexible and highly active transposon as compared to Sleeping Beauty , Tol2 , and Mos1 in mammalian cells

    PNAS 2006 103:15008-15013; published ahead of print September 27, 2006, doi:10.1073/pnas.0606979103
    • See commentary article on page 14981 in issue 41 of volume 103
  • Biological Sciences - Applied Biological Sciences:
    • Zhiyong Ding,
    • Jiyong Liang,
    • Yiling Lu,
    • Qinghua Yu,
    • Zhou Songyang,
    • Shiaw-Yih Lin,
    • and Gordon B. Mills

    A retrovirus-based protein complementation assay screen reveals functional AKT1-binding partners

    PNAS 2006 103:15014-15019; published ahead of print October 3, 2006, doi:10.1073/pnas.0606917103

Biochemistry

  • Physical Sciences - Chemistry - Biological Sciences - Biochemistry:
    • Anirban Banerjee
    • and Gregory L. Verdine

    A nucleobase lesion remodels the interaction of its normal neighbor in a DNA glycosylase complex

    PNAS 2006 103:15020-15025; published ahead of print October 2, 2006, doi:10.1073/pnas.0603644103
  • Biological Sciences - Biochemistry:
    • Christoph Mueller-Dieckmann,
    • Stefan Kernstock,
    • Michael Lisurek,
    • Jens Peter von Kries,
    • Friedrich Haag,
    • Manfred S. Weiss,
    • and Friedrich Koch-Nolte

    The structure of human ADP-ribosylhydrolase 3 (ARH3) provides insights into the reversibility of protein ADP-ribosylation

    PNAS 2006 103:15026-15031; published ahead of print October 2, 2006, doi:10.1073/pnas.0606762103
  • Biological Sciences - Biochemistry:
    • Peter M. Brown,
    • Tom T. Caradoc-Davies,
    • James M. J. Dickson,
    • Garth J. S. Cooper,
    • Kerry M. Loomes,
    • and Edward N. Baker

    Crystal structure of a substrate complex of myo -inositol oxygenase, a di-iron oxygenase with a key role in inositol metabolism

    PNAS 2006 103:15032-15037; published ahead of print September 29, 2006, doi:10.1073/pnas.0605143103
  • Biological Sciences - Biochemistry:
    • Kristine M. Robinson,
    • Michael S. Janes,
    • Mariana Pehar,
    • Jeffrey S. Monette,
    • Meredith F. Ross,
    • Tory M. Hagen,
    • Michael P. Murphy,
    • and Joseph S. Beckman

    Selective fluorescent imaging of superoxide in vivo using ethidium-based probes

    PNAS 2006 103:15038-15043; published ahead of print October 2, 2006, doi:10.1073/pnas.0601945103
    Open Access Article
  • Biological Sciences - Biochemistry:
    • Robyn D. Moir,
    • JaeHoon Lee,
    • Rebecca A. Haeusler,
    • Neelam Desai,
    • David R. Engelke,
    • and Ian M. Willis

    Protein kinase A regulates RNA polymerase III transcription through the nuclear localization of Maf1

    PNAS 2006 103:15044-15049; published ahead of print September 27, 2006, doi:10.1073/pnas.0607129103

Biophysics

  • Biological Sciences - Biophysics - Physical Sciences - Physics:
    • Yaroslav Tserkovnyak
    • and David R. Nelson

    Conditions for extreme sensitivity of protein diffusion in membranes to cell environments

    PNAS 2006 103:15002-15007; published ahead of print September 28, 2006, doi:10.1073/pnas.0606992103
  • Biological Sciences - Biophysics:
    • L. J. G. W. van Wilderen,
    • M. A. van der Horst,
    • I. H. M. van Stokkum,
    • K. J. Hellingwerf,
    • R. van Grondelle,
    • and M. L. Groot

    Ultrafast infrared spectroscopy reveals a key step for successful entry into the photocycle for photoactive yellow protein

    PNAS 2006 103:15050-15055; published ahead of print October 2, 2006, doi:10.1073/pnas.0603476103
  • Biological Sciences - Biophysics:
    • Andreas C. Joerger,
    • Hwee Ching Ang,
    • and Alan R. Fersht

    From the Cover: Structural basis for understanding oncogenic p53 mutations and designing rescue drugs

    PNAS 2006 103:15056-15061; published ahead of print October 2, 2006, doi:10.1073/pnas.0607286103
  • Biological Sciences - Biophysics:
    • Junji Iwahara,
    • Markus Zweckstetter,
    • and G. Marius Clore

    NMR structural and kinetic characterization of a homeodomain diffusing and hopping on nonspecific DNA

    PNAS 2006 103:15062-15067; published ahead of print September 28, 2006, doi:10.1073/pnas.0605868103
  • Biological Sciences - Biophysics:
    • Philip D. Blood
    • and Gregory A. Voth

    Direct observation of Bin/amphiphysin/Rvs (BAR) domain-induced membrane curvature by means of molecular dynamics simulations

    PNAS 2006 103:15068-15072; published ahead of print September 28, 2006, doi:10.1073/pnas.0603917103

Cell Biology

  • Biological Sciences - Cell Biology:
    • Mark S. Eller,
    • Xiaodong Liao,
    • SuiYang Liu,
    • Kendra Hanna,
    • Helena Bäckvall,
    • Patricia L. Opresko,
    • Vilhelm A. Bohr,
    • and Barbara A. Gilchrest

    A role for WRN in telomere-based DNA damage responses

    PNAS 2006 103:15073-15078; published ahead of print October 2, 2006, doi:10.1073/pnas.0607332103
    Open Access Article
  • Biological Sciences - Cell Biology:
    • J. C. Tapia,
    • V. A. Torres,
    • D. A. Rodriguez,
    • L. Leyton,
    • and A. F. G. Quest

    Casein kinase 2 (CK2) increases survivin expression via enhanced β-catenin–T cell factor/lymphoid enhancer binding factor-dependent transcription

    PNAS 2006 103:15079-15084; published ahead of print September 27, 2006, doi:10.1073/pnas.0606845103
  • Biological Sciences - Cell Biology:
    • Ivan V. Litvinov,
    • Donald J. Vander Griend,
    • Lizamma Antony,
    • Susan Dalrymple,
    • Angelo M. De Marzo,
    • Charles G. Drake,
    • and John T. Isaacs

    Androgen receptor as a licensing factor for DNA replication in androgen-sensitive prostate cancer cells

    PNAS 2006 103:15085-15090; published ahead of print October 2, 2006, doi:10.1073/pnas.0603057103
  • Biological Sciences - Cell Biology:
    • Casey M. Clements,
    • Richard S. McNally,
    • Brian J. Conti,
    • Tak W. Mak,
    • and Jenny P.-Y. Ting

    DJ-1, a cancer- and Parkinson's disease-associated protein, stabilizes the antioxidant transcriptional master regulator Nrf2

    PNAS 2006 103:15091-15096; published ahead of print October 2, 2006, doi:10.1073/pnas.0607260103
    Open Access Article
  • Biological Sciences - Cell Biology:
    • Paul S. Maddox,
    • Nathan Portier,
    • Arshad Desai,
    • and Karen Oegema

    Molecular analysis of mitotic chromosome condensation using a quantitative time-resolved fluorescence microscopy assay

    PNAS 2006 103:15097-15102; published ahead of print September 27, 2006, doi:10.1073/pnas.0606993103

Developmental Biology

  • Biological Sciences - Developmental Biology:
    • Scott D. Weatherbee,
    • Richard R. Behringer,
    • John J. Rasweiler, IV,
    • and Lee A. Niswander

    Interdigital webbing retention in bat wings illustrates genetic changes underlying amniote limb diversification

    PNAS 2006 103:15103-15107; published ahead of print October 2, 2006, doi:10.1073/pnas.0604934103
  • Biological Sciences - Developmental Biology:
    • Nayoung Suh,
    • Britta Jedamzik,
    • Christian R. Eckmann,
    • Marvin Wickens,
    • and Judith Kimble

    The GLD-2 poly(A) polymerase activates gld-1 mRNA in the Caenorhabditis elegans germ line

    PNAS 2006 103:15108-15112; published ahead of print September 29, 2006, doi:10.1073/pnas.0607050103

Evolution

  • Biological Sciences - Evolution:
    • Montserrat Gomendio,
    • Juan Martin-Coello,
    • Cristina Crespo,
    • Concepción Magaña,
    • and Eduardo R. S. Roldan

    From the Cover: Sperm competition enhances functional capacity of mammalian spermatozoa

    PNAS 2006 103:15113-15117; published ahead of print September 21, 2006, doi:10.1073/pnas.0605795103
    Open Access Article
    • See commentary article on page 14983 in issue 41 of volume 103
  • Biological Sciences - Evolution:
    • Bryan N. Danforth,
    • Sedonia Sipes,
    • Jennifer Fang,
    • and Seán G. Brady

    The history of early bee diversification based on five genes plus morphology

    PNAS 2006 103:15118-15123; published ahead of print October 2, 2006, doi:10.1073/pnas.0604033103
    Open Access Article

Genetics

  • Biological Sciences - Genetics:
    • Joshua P. Gnerer,
    • Robert A. Kreber,
    • and Barry Ganetzky

    Inaugural Article: wasted away , a Drosophila mutation in triosephosphate isomerase, causes paralysis, neurodegeneration, and early death

    PNAS 2006 103:14987-14993; published ahead of print September 28, 2006, doi:10.1073/pnas.0606887103
    Open Access Article
    • See commentary article on page 11515 in issue 28 of volume 104
  • Biological Sciences - Genetics:
    • Ma-Li Wong,
    • Fiona Whelan,
    • Panagiotis Deloukas,
    • Pamela Whittaker,
    • Marcos Delgado,
    • Rita M. Cantor,
    • Samuel M. McCann,
    • and Julio Licinio

    Phosphodiesterase genes are associated with susceptibility to major depression and antidepressant treatment response

    PNAS 2006 103:15124-15129; published ahead of print September 28, 2006, doi:10.1073/pnas.0602795103
    Open Access Article

Immunology

  • Biological Sciences - Immunology:
    • Rick Janssens,
    • Sylvia Dekker,
    • Rudi W. Hendriks,
    • George Panayotou,
    • Alexandra van Remoortere,
    • John Kong-a San,
    • Frank Grosveld,
    • and Dubravka Drabek

    Generation of heavy-chain-only antibodies in mice

    PNAS 2006 103:15130-15135; published ahead of print October 2, 2006, doi:10.1073/pnas.0601108103
    Open Access Article
  • Biological Sciences - Immunology:
    • Hideo Negishi,
    • Yasuyuki Fujita,
    • Hideyuki Yanai,
    • Shinya Sakaguchi,
    • Xinshou Ouyang,
    • Masahiro Shinohara,
    • Hiroshi Takayanagi,
    • Yusuke Ohba,
    • Tadatsugu Taniguchi,
    • and Kenya Honda

    Evidence for licensing of IFN-γ-induced IFN regulatory factor 1 transcription factor by MyD88 in Toll-like receptor-dependent gene induction program

    PNAS 2006 103:15136-15141; published ahead of print October 3, 2006, doi:10.1073/pnas.0607181103
    Open Access Article
  • Biological Sciences - Immunology:
    • Roland Reibke,
    • Natalio Garbi,
    • Ruth Ganss,
    • Günter J. Hämmerling,
    • Bernd Arnold,
    • and Thilo Oelert

    CD8 + regulatory T cells generated by neonatal recognition of peripheral self-antigen

    PNAS 2006 103:15142-15147; published ahead of print September 28, 2006, doi:10.1073/pnas.0602622103

Medical Sciences

  • Biological Sciences - Medical Sciences:
    • Kazuto Nakada,
    • Akitsugu Sato,
    • Kayo Yoshida,
    • Takashi Morita,
    • Hiromitsu Tanaka,
    • Shin-Ichi Inoue,
    • Hiromichi Yonekawa,
    • and Jun-Ichi Hayashi

    Mitochondria-related male infertility

    PNAS 2006 103:15148-15153; published ahead of print September 27, 2006, doi:10.1073/pnas.0604641103
  • Biological Sciences - Medical Sciences:
    • Michael Cappello,
    • Richard D. Bungiro,
    • Lisa M. Harrison,
    • Larry J. Bischof,
    • Joel S. Griffitts,
    • Brad D. Barrows,
    • and Raffi V. Aroian

    A purified Bacillus thuringiensis crystal protein with therapeutic activity against the hookworm parasite Ancylostoma ceylanicum

    PNAS 2006 103:15154-15159; published ahead of print September 27, 2006, doi:10.1073/pnas.0607002103
  • Biological Sciences - Medical Sciences:
    • Rebecca L. Dunfee,
    • Elaine R. Thomas,
    • Paul R. Gorry,
    • Jianbin Wang,
    • Joann Taylor,
    • Kevin Kunstman,
    • Steven M. Wolinsky,
    • and Dana Gabuzda

    The HIV Env variant N283 enhances macrophage tropism and is associated with brain infection and dementia

    PNAS 2006 103:15160-15165; published ahead of print October 2, 2006, doi:10.1073/pnas.0605513103
    Open Access Article
  • Biological Sciences - Medical Sciences:
    • Hatem E. Sabaawy,
    • Mizuki Azuma,
    • Lisa J. Embree,
    • Huai-Jen Tsai,
    • Matthew F. Starost,
    • and Dennis D. Hickstein

    TEL-AML1 transgenic zebrafish model of precursor B cell acute lymphoblastic leukemia

    PNAS 2006 103:15166-15171; published ahead of print October 2, 2006, doi:10.1073/pnas.0603349103
  • Biological Sciences - Medical Sciences:
    • William S. Sly,
    • Carole Vogler,
    • Jeffrey H. Grubb,
    • Beth Levy,
    • Nancy Galvin,
    • Yun Tan,
    • Tatsuo Nishioka,
    • and Shunji Tomatsu

    Enzyme therapy in mannose receptor-null mucopolysaccharidosis VII mice defines roles for the mannose 6-phosphate and mannose receptors

    PNAS 2006 103:15172-15177; published ahead of print October 2, 2006, doi:10.1073/pnas.0607053103
  • Biological Sciences - Medical Sciences:
    • Shenping Liu,
    • Jeanne S. Chang,
    • John T. Herberg,
    • Miao-Miao Horng,
    • Paul K. Tomich,
    • Alice H. Lin,
    • and Keith R. Marotti

    Allosteric inhibition of Staphylococcus aureus d -alanine: d -alanine ligase revealed by crystallographic studies

    PNAS 2006 103:15178-15183; published ahead of print October 2, 2006, doi:10.1073/pnas.0604905103
  • Biological Sciences - Medical Sciences:
    • Marika Massaro,
    • Aida Habib,
    • Laura Lubrano,
    • Serena Del Turco,
    • Guido Lazzerini,
    • Todd Bourcier,
    • Babette B. Weksler,
    • and Raffaele De Caterina

    The omega-3 fatty acid docosahexaenoate attenuates endothelial cyclooxygenase-2 induction through both NADP(H) oxidase and PKCε inhibition

    PNAS 2006 103:15184-15189; published ahead of print October 3, 2006, doi:10.1073/pnas.0510086103

Microbiology

  • Biological Sciences - Microbiology:
    • James R. Boyne
    • and Adrian Whitehouse

    Nucleolar trafficking is essential for nuclear export of intronless herpesvirus mRNA

    PNAS 2006 103:15190-15195; published ahead of print September 27, 2006, doi:10.1073/pnas.0604890103
  • Biological Sciences - Microbiology:
    • Nichole A. Broderick,
    • Kenneth F. Raffa,
    • and Jo Handelsman

    Midgut bacteria required for Bacillus thuringiensis insecticidal activity

    PNAS 2006 103:15196-15199; published ahead of print September 27, 2006, doi:10.1073/pnas.0604865103
  • Biological Sciences - Microbiology:
    • B. S. Goldman,
    • W. C. Nierman,
    • D. Kaiser,
    • S. C. Slater,
    • A. S. Durkin,
    • J. A. Eisen,
    • C. M. Ronning,
      • <