Commentaries

  • Commentary:
    • Steven A. Kliewer

    Cholesterol detoxification by the nuclear pregnane X receptor

    PNAS 2005 102:2675-2676; published ahead of print February 14, 2005, doi:10.1073/pnas.0500159102
    • See companion article on page 2198 in issue 6 of volume 102
  • Commentary:
    • David Stokoe
    • and Joseph F. Costello

    Phosphatase and tensin homologue growth suppression without phosphatase

    PNAS 2005 102:2677-2678; published ahead of print February 14, 2005, doi:10.1073/pnas.0500089102
    • See companion article on page 2703 in issue 8 of volume 102
  • Commentary:
    • Rubén Claudio Aguilar
    • and Beverly Wendland

    Endocytosis of membrane receptors: Two pathways are better than one

    PNAS 2005 102:2679-2680; published ahead of print February 14, 2005, doi:10.1073/pnas.0500213102
    • See companion article on page 2766 in issue 8 of volume 102
    • See companion article on page 2760 in issue 8 of volume 102
  • Commentary:
    • Lee Kroos

    Eukaryotic-like signaling and gene regulation in a prokaryote that undergoes multicellular development

    PNAS 2005 102:2681-2682; published ahead of print February 14, 2005, doi:10.1073/pnas.0500157102
    • See companion article on page 3010 in issue 8 of volume 102
  • Commentary:
    • Leslie A. Real

    The community-wide dilemma of hospital-acquired drug resistance

    PNAS 2005 102:2683-2684; published ahead of print February 14, 2005, doi:10.1073/pnas.0500088102
    • See companion article on page 3153 in issue 8 of volume 102

In This Issue

Physical Sciences

Engineering

  • Physical Sciences - Engineering - Biological Sciences - Genetics:
    • Kiran Raosaheb Patil
    • and Jens Nielsen

    Uncovering transcriptional regulation of metabolism by using metabolic network topology

    PNAS 2005 102:2685-2689; published ahead of print February 14, 2005, doi:10.1073/pnas.0406811102

Mathematics

  • Physical Sciences - Mathematics:
    • J. Haglund,
    • M. Haiman,
    • and N. Loehr

    From the Cover: Combinatorial theory of Macdonald polynomials I: Proof of Haglund's formula

    PNAS 2005 102:2690-2696; published ahead of print January 13, 2005, doi:10.1073/pnas.0408497102

Biological Sciences

Applied Biological Sciences

  • Biological Sciences - Applied Biological Sciences:
    • Mark R. Proctor,
    • Edward J. Taylor,
    • Didier Nurizzo,
    • Johan P. Turkenburg,
    • Ruth M. Lloyd,
    • Maria Vardakou,
    • Gideon J. Davies,
    • and Harry J. Gilbert

    Tailored catalysts for plant cell-wall degradation: Redesigning the exo/endo preference of Cellvibrio japonicus arabinanase 43A

    PNAS 2005 102:2697-2702; published ahead of print February 11, 2005, doi:10.1073/pnas.0500051102

Biochemistry

  • Biological Sciences - Biochemistry:
    • Koichi Okumura,
    • Mujun Zhao,
    • Ronald A. DePinho,
    • Frank B. Furnari,
    • and Webster K. Cavenee

    From the Cover: Cellular transformation by the MSP58 oncogene is inhibited by its physical interaction with the PTEN tumor suppressor

    PNAS 2005 102:2703-2706; published ahead of print January 19, 2005, doi:10.1073/pnas.0409370102
    • See commentary article on page 2677 in issue 8 of volume 102
  • Biological Sciences - Biochemistry:
    • Junhui Zhang,
    • Jessica Simisky,
    • Francis T. F. Tsai,
    • and David S. Geller

    A critical role of helix 3–helix 5 interaction in steroid hormone receptor function

    PNAS 2005 102:2707-2712; published ahead of print February 14, 2005, doi:10.1073/pnas.0409663102
  • Biological Sciences - Biochemistry:
    • Jason F. Flores,
    • Charles R. Fisher,
    • Susan L. Carney,
    • Brian N. Green,
    • John K. Freytag,
    • Stephen W. Schaeffer,
    • and William E. Royer, Jr.

    Sulfide binding is mediated by zinc ions discovered in the crystal structure of a hydrothermal vent tubeworm hemoglobin

    PNAS 2005 102:2713-2718; published ahead of print February 14, 2005, doi:10.1073/pnas.0407455102
  • Biological Sciences - Biochemistry:
    • Elizabeth Buck
    • and James A. Wells

    Disulfide trapping to localize small-molecule agonists and antagonists for a G protein-coupled receptor

    PNAS 2005 102:2719-2724; published ahead of print February 14, 2005, doi:10.1073/pnas.0500016102
  • Biological Sciences - Biochemistry:
    • Tadashi Yamashita,
    • Yun-Ping Wu,
    • Roger Sandhoff,
    • Norbert Werth,
    • Hiroki Mizukami,
    • Jessica M. Ellis,
    • Jeffrey L. Dupree,
    • Rudolf Geyer,
    • Konrad Sandhoff,
    • and Richard L. Proia

    Interruption of ganglioside synthesis produces central nervous system degeneration and altered axon–glial interactions

    PNAS 2005 102:2725-2730; published ahead of print February 14, 2005, doi:10.1073/pnas.0407785102
  • Biological Sciences - Biochemistry:
    • Haiyu Zhang,
    • María R. Gómez-García,
    • Michael R. W. Brown,
    • and Arthur Kornberg

    Inorganic polyphosphate in Dictyostelium discoideum : Influence on development, sporulation, and predation

    PNAS 2005 102:2731-2735; published ahead of print February 8, 2005, doi:10.1073/pnas.0500023102

Biophysics

  • Biological Sciences - Biophysics:
    • H. El-Samad,
    • H. Kurata,
    • J. C. Doyle,
    • C. A. Gross,
    • and M. Khammash

    Surviving heat shock: Control strategies for robustness and performance

    PNAS 2005 102:2736-2741; published ahead of print January 24, 2005, doi:10.1073/pnas.0403510102
    • See commentary article on page 4219 in issue 12 of volume 102
  • Biological Sciences - Biophysics:
    • J. P. Johnson, Jr.
    • and William N. Zagotta

    The carboxyl-terminal region of cyclic nucleotide-modulated channels is a gating ring, not a permeation path

    PNAS 2005 102:2742-2747; published ahead of print February 14, 2005, doi:10.1073/pnas.0408323102
  • Biological Sciences - Biophysics:
    • Tetsunari Kimura,
    • Takanori Uzawa,
    • Koichiro Ishimori,
    • Isao Morishima,
    • Satoshi Takahashi,
    • Takashi Konno,
    • Shuji Akiyama,
    • and Tetsuro Fujisawa

    Specific collapse followed by slow hydrogen-bond formation of β-sheet in the folding of single-chain monellin

    PNAS 2005 102:2748-2753; published ahead of print February 14, 2005, doi:10.1073/pnas.0407982102
  • Biological Sciences - Biophysics:
    • Benjamin Schuler,
    • Everett A. Lipman,
    • Peter J. Steinbach,
    • Michael Kumke,
    • and William A. Eaton

    Polyproline and the “spectroscopic ruler” revisited with single-molecule fluorescence

    PNAS 2005 102:2754-2759; published ahead of print February 7, 2005, doi:10.1073/pnas.0408164102

Cell Biology

  • Biological Sciences - Cell Biology:
    • Sara Sigismund,
    • Tanja Woelk,
    • Claudia Puri,
    • Elena Maspero,
    • Carlo Tacchetti,
    • Pietro Transidico,
    • Pier Paolo Di Fiore,
    • and Simona Polo

    From the Cover: Clathrin-independent endocytosis of ubiquitinated cargos

    PNAS 2005 102:2760-2765; published ahead of print February 8, 2005, doi:10.1073/pnas.0409817102
    • See commentary article on page 2679 in issue 8 of volume 102
  • Biological Sciences - Cell Biology:
    • Hong Chen
    • and Pietro De Camilli

    From the Cover: The association of epsin with ubiquitinated cargo along the endocytic pathway is negatively regulated by its interaction with clathrin

    PNAS 2005 102:2766-2771; published ahead of print February 8, 2005, doi:10.1073/pnas.0409719102
    • See commentary article on page 2679 in issue 8 of volume 102
  • Biological Sciences - Cell Biology:
    • Marek Cyrklaff,
    • Cristina Risco,
    • Jose Jesús Fernández,
    • Maria Victoria Jiménez,
    • Mariano Estéban,
    • Wolfgang Baumeister,
    • and José L. Carrascosa

    Cryo-electron tomography of vaccinia virus

    PNAS 2005 102:2772-2777; published ahead of print February 7, 2005, doi:10.1073/pnas.0409825102
  • Biological Sciences - Cell Biology:
    • Zhigang Lu,
    • Chuanmao Zhang,
    • and Zhonghe Zhai

    Nucleoplasmin regulates chromatin condensation during apoptosis

    PNAS 2005 102:2778-2783; published ahead of print February 7, 2005, doi:10.1073/pnas.0405374102
  • Biological Sciences - Cell Biology:
    • Kai-Feng Xu,
    • Xiaoyan Shen,
    • Hewang Li,
    • Gustavo Pacheco-Rodriguez,
    • Joel Moss,
    • and Martha Vaughan

    Interaction of BIG2, a brefeldin A-inhibited guanine nucleotide-exchange protein, with exocyst protein Exo70

    PNAS 2005 102:2784-2789; published ahead of print February 10, 2005, doi:10.1073/pnas.0409871102
  • Biological Sciences - Cell Biology:
    • Elöd Z. Szabó,
    • Masayuki Numata,
    • Viktoria Lukashova,
    • Pietro Iannuzzi,
    • and John Orlowski

    β-Arrestins bind and decrease cell-surface abundance of the Na + /H + exchanger NHE5 isoform

    PNAS 2005 102:2790-2795; published ahead of print February 7, 2005, doi:10.1073/pnas.0407444102
  • Biological Sciences - Cell Biology:
    • Noriaki Kitamura,
    • Masahiko Ikekita,
    • Takeshi Sato,
    • Yoshihiro Akimoto,
    • Yasumaru Hatanaka,
    • Hayato Kawakami,
    • Mitsushi Inomata,
    • and Kiyoshi Furukawa

    Mouse Na + /K + -ATPase β1-subunit has a K + -dependent cell adhesion activity for β-GlcNAc-terminating glycans

    PNAS 2005 102:2796-2801; published ahead of print February 10, 2005, doi:10.1073/pnas.0409344102
  • Biological Sciences - Cell Biology:
    • Qinghong Zhang,
    • Amanda Nottke,
    • and Richard H. Goodman

    Homeodomain-interacting protein kinase-2 mediates CtBP phosphorylation and degradation in UV-triggered apoptosis

    PNAS 2005 102:2802-2807; published ahead of print February 11, 2005, doi:10.1073/pnas.0409373102

Developmental Biology

  • Biological Sciences - Developmental Biology:
    • Igor Martianov,
    • Stefano Brancorsini,
    • Raffaella Catena,
    • Anne Gansmuller,
    • Noora Kotaja,
    • Martti Parvinen,
    • Paolo Sassone-Corsi,
    • and Irwin Davidson

    Polar nuclear localization of H1T2, a histone H1 variant, required for spermatid elongation and DNA condensation during spermiogenesis

    PNAS 2005 102:2808-2813; published ahead of print February 14, 2005, doi:10.1073/pnas.0406060102
  • Biological Sciences - Developmental Biology:
    • Yoko Omoto,
    • Richard Lathe,
    • Margaret Warner,
    • and Jan-Åke Gustafsson

    Early onset of puberty and early ovarian failure in CYP7B1 knockout mice

    PNAS 2005 102:2814-2819; published ahead of print February 14, 2005, doi:10.1073/pnas.0500198102
  • Biological Sciences - Developmental Biology:
    • Ching-Wei Luo,
    • Elizabeth M. Dewey,
    • Satoko Sudo,
    • John Ewer,
    • Sheau Yu Hsu,
    • Hans-Willi Honegger,
    • and Aaron J. W. Hsueh

    Bursicon, the insect cuticle-hardening hormone, is a heterodimeric cystine knot protein that activates G protein-coupled receptor LGR2

    PNAS 2005 102:2820-2825; published ahead of print February 9, 2005, doi:10.1073/pnas.0409916102

Ecology

  • Biological Sciences - Ecology:
    • Thorsten B. H. Reusch,
    • Anneli Ehlers,
    • August Hämmerli,
    • and Boris Worm

    Ecosystem recovery after climatic extremes enhanced by genotypic diversity

    PNAS 2005 102:2826-2831; published ahead of print February 14, 2005, doi:10.1073/pnas.0500008102

Evolution

  • Biological Sciences - Evolution:
    • Sara L. Sawyer,
    • Lily I. Wu,
    • Michael Emerman,
    • and Harmit S. Malik

    Positive selection of primate TRIM5 α identifies a critical species-specific retroviral restriction domain

    PNAS 2005 102:2832-2837; published ahead of print February 2, 2005, doi:10.1073/pnas.0409853102
    • See commentary article on page 3179 in issue 9 of volume 102
  • Biological Sciences - Evolution:
    • Jenni E. Pettay,
    • Loeske E. B. Kruuk,
    • Jukka Jokela,
    • and Virpi Lummaa

    Heritability and genetic constraints of life-history trait evolution in preindustrial humans

    PNAS 2005 102:2838-2843; published ahead of print February 8, 2005, doi:10.1073/pnas.0406709102
  • Biological Sciences - Evolution:
    • Yunling Wang,
    • Lene Jensen,
    • Peter Højrup,
    • and David Morse

    Synthesis and degradation of dinoflagellate plastid-encoded psbA proteins are light-regulated, not circadian-regulated

    PNAS 2005 102:2844-2849; published ahead of print February 9, 2005, doi:10.1073/pnas.0406522102

Genetics

  • Physical Sciences - Engineering - Biological Sciences - Genetics:
    • Kiran Raosaheb Patil
    • and Jens Nielsen

    Uncovering transcriptional regulation of metabolism by using metabolic network topology

    PNAS 2005 102:2685-2689; published ahead of print February 14, 2005, doi:10.1073/pnas.0406811102
  • Biological Sciences - Genetics:
    • Gene W. Yeo,
    • Eric Van Nostrand,
    • Dirk Holste,
    • Tomaso Poggio,
    • and Christopher B. Burge

    Identification and analysis of alternative splicing events conserved in human and mouse

    PNAS 2005 102:2850-2855; published ahead of print February 11, 2005, doi:10.1073/pnas.0409742102
  • Biological Sciences - Genetics:
    • Nilangshu Das,
    • Majda Valjavec-Gratian,
    • Ashish N. Basuray,
    • Richard A. Fekete,
    • Peter P. Papp,
    • Johan Paulsson,
    • and Dhruba K. Chattoraj

    Multiple homeostatic mechanisms in the control of P1 plasmid replication

    PNAS 2005 102:2856-2861; published ahead of print February 11, 2005, doi:10.1073/pnas.0409790102
  • Biological Sciences - Genetics:
    • Igor Zwir,
    • Dongwoo Shin,
    • Akinori Kato,
    • Kunihiko Nishino,
    • Tammy Latifi,
    • Felix Solomon,
    • Janelle M. Hare,
    • Henry Huang,
    • and Eduardo A. Groisman

    Dissecting the PhoP regulatory network of Escherichia coli and Salmonella enterica

    PNAS 2005 102:2862-2867; published ahead of print February 9, 2005, doi:10.1073/pnas.0408238102
  • Biological Sciences - Genetics:
    • Jackie Haines,
    • Victoria Johnson,
    • Kevin Pack,
    • Nirosha Suraweera,
    • Predrag Slijepcevic,
    • Erik Cabuy,
    • Margaret Coster,
    • Mohammad Ilyas,
    • Jennifer Wilding,
    • Oliver Sieber,
    • Walter Bodmer,
    • Ian Tomlinson,
    • and Andrew Silver

    Genetic basis of variation in adenoma multiplicity in Apc Min /+ Mom1 S mice

    PNAS 2005 102:2868-2873; published ahead of print February 14, 2005, doi:10.1073/pnas.0500039102

Immunology

  • Biological Sciences - Immunology:
    • Julia Hauer,
    • Stephanie Püschner,
    • Parameswaran Ramakrishnan,
    • Ute Simon,
    • Martina Bongers,
    • Christine Federle,
    • and Hartmut Engelmann

    TNF receptor (TNFR)-associated factor (TRAF) 3 serves as an inhibitor of TRAF2/5-mediated activation of the noncanonical NF-κB pathway by TRAF-binding TNFRs

    PNAS 2005 102:2874-2879; published ahead of print February 11, 2005, doi:10.1073/pnas.0500187102
  • Biological Sciences - Immunology:
    • Mansour Mohamadzadeh,
    • Scott Olson,
    • Warren V. Kalina,
    • Gordon Ruthel,
    • Gretchen L. Demmin,
    • Kelly L. Warfield,
    • Sina Bavari,
    • and Todd R. Klaenhammer

    Lactobacilli activate human dendritic cells that skew T cells toward T helper 1 polarization

    PNAS 2005 102:2880-2885; published ahead of print February 14, 2005, doi:10.1073/pnas.0500098102
  • Biological Sciences - Immunology:
    • Domenico Mavilio,
    • Gabriella Lombardo,
    • Janet Benjamin,
    • Diana Kim,
    • Dean Follman,
    • Emanuela Marcenaro,
    • M. Angeline O'Shea,
    • Audre