Commentaries

  • Commentary:
    • Michael Brenowitz,
    • Dorothy A. Erie,
    • and Mark R. Chance

    Catching RNA polymerase in the act of binding: Intermediates in transcription illuminated by synchrotron footprinting

    PNAS 2005 102:4659-4660; published ahead of print March 21, 2005, doi:10.1073/pnas.0501152102
    • See companion article on page 4706 in issue 13 of volume 102
  • Commentary:
    • Luis Aragón

    Sumoylation: A new wrestler in the DNA repair ring

    PNAS 2005 102:4661-4662; published ahead of print March 21, 2005, doi:10.1073/pnas.0501342102
    • See companion article on page 4777 in issue 13 of volume 102

In This Issue

Biography

  • Biography:
    • Regina Nuzzo

    Inaugural Article: Biography of George E. Andrews

    PNAS 2005 102:4663-4665; published ahead of print March 21, 2005, doi:10.1073/pnas.0501311102
    • See commentary article on page 4666 in issue 13 of volume 102

Physical Sciences

Applied Physical Sciences

  • Physical Sciences - Applied Physical Sciences:
    • Richard A. Gray
    • and Nipon Chattipakorn

    Termination of spiral waves during cardiac fibrillation via shock-induced phase resetting

    PNAS 2005 102:4672-4677; published ahead of print March 15, 2005, doi:10.1073/pnas.0407860102

Chemistry

  • Physical Sciences - Chemistry:
    • Myung-Han Yoon,
    • Antonio Facchetti,
    • and Tobin J. Marks

    From the Cover: σ-π molecular dielectric multilayers for low-voltage organic thin-film transistors

    PNAS 2005 102:4678-4682; published ahead of print March 21, 2005, doi:10.1073/pnas.0501027102
  • Physical Sciences - Chemistry:
    • Christophe Letondor,
    • Nicolas Humbert,
    • and Thomas R. Ward

    Artificial metalloenzymes based on biotin-avidin technology for the enantioselective reduction of ketones by transfer hydrogenation

    PNAS 2005 102:4683-4687; published ahead of print March 16, 2005, doi:10.1073/pnas.0409684102

Engineering

  • Physical Sciences - Engineering:
    • Pankaj Karande,
    • Amit Jain,
    • Kaitlin Ergun,
    • Vincent Kispersky,
    • and Samir Mitragotri

    Design principles of chemical penetration enhancers for transdermal drug delivery

    PNAS 2005 102:4688-4693; published ahead of print March 17, 2005, doi:10.1073/pnas.0501176102

Mathematics

  • Physical Sciences - Mathematics:
    • George E. Andrews

    Inaugural Article: Partitions with short sequences and mock theta functions

    PNAS 2005 102:4666-4671; published ahead of print February 16, 2005, doi:10.1073/pnas.0500218102
    • See commentary article on page 4663 in issue 13 of volume 102

Social Sciences

Social Sciences

  • Social Sciences - Social Sciences:
    • William R. Shankle,
    • A. Kimball Romney,
    • Junko Hara,
    • Dennis Fortier,
    • Malcolm B. Dick,
    • James M. Chen,
    • Timothy Chan,
    • and Xijiang Sun

    Methods to improve the detection of mild cognitive impairment

    PNAS 2005 102:4919-4924; published ahead of print March 21, 2005, doi:10.1073/pnas.0501157102

Biological Sciences

Applied Biological Sciences

  • Biological Sciences - Applied Biological Sciences:
    • Hui Song,
    • Renxiao Wang,
    • Shaomeng Wang,
    • and Jiayuh Lin

    A low-molecular-weight compound discovered through virtual database screening inhibits Stat3 function in breast cancer cells

    PNAS 2005 102:4700-4705; published ahead of print March 21, 2005, doi:10.1073/pnas.0409894102

Biochemistry

  • Biological Sciences - Biochemistry:
    • Bianca Sclavi,
    • Evgeny Zaychikov,
    • Anastasia Rogozina,
    • Ferdinand Walther,
    • Malcolm Buckle,
    • and Hermann Heumann

    From the Cover: Real-time characterization of intermediates in the pathway to open complex formation by Escherichia coli RNA polymerase at the T7A1 promoter

    PNAS 2005 102:4706-4711; published ahead of print February 28, 2005, doi:10.1073/pnas.0408218102
    • See commentary article on page 4659 in issue 13 of volume 102
  • Biological Sciences - Biochemistry:
    • Guanghan Gao,
    • Agda M. Simpson,
    • Xuedong Kang,
    • Kestrel Rogers,
    • Martina Nebohacova,
    • Feng Li,
    • and Larry Simpson

    Functional complementation of Trypanosoma brucei RNA in vitro editing with recombinant RNA ligase

    PNAS 2005 102:4712-4717; published ahead of print March 21, 2005, doi:10.1073/pnas.0500553102
  • Biological Sciences - Biochemistry:
    • Fernando Rodríguez,
    • Catherine C. Allende,
    • and Jorge E. Allende

    Protein kinase casein kinase 2 holoenzyme produced ectopically in human cells can be exported to the external side of the cellular membrane

    PNAS 2005 102:4718-4723; published ahead of print March 17, 2005, doi:10.1073/pnas.0501074102
  • Biological Sciences - Biochemistry:
    • Kevin D. Healy,
    • Janeen L. Vanhooke,
    • Jean M. Prahl,
    • and Hector F. DeLuca

    Parathyroid hormone decreases renal vitamin D receptor expression in vivo

    PNAS 2005 102:4724-4728; published ahead of print March 15, 2005, doi:10.1073/pnas.0501312102

Biophysics

  • Biological Sciences - Biophysics:
    • Friedrich Förster,
    • Ohad Medalia,
    • Nathan Zauberman,
    • Wolfgang Baumeister,
    • and Deborah Fass

    Retrovirus envelope protein complex structure in situ studied by cryo-electron tomography

    PNAS 2005 102:4729-4734; published ahead of print March 17, 2005, doi:10.1073/pnas.0409178102
  • Biological Sciences - Biophysics:
    • Maria Rosario Fernandez-Fernandez,
    • Dmitry B. Veprintsev,
    • and Alan R. Fersht

    Proteins of the S100 family regulate the oligomerization of p53 tumor suppressor

    PNAS 2005 102:4735-4740; published ahead of print March 21, 2005, doi:10.1073/pnas.0501459102
  • Biological Sciences - Biophysics:
    • Haripada Maity,
    • Mita Maity,
    • Mallela M. G. Krishna,
    • Leland Mayne,
    • and S. Walter Englander

    Protein folding: The stepwise assembly of foldon units

    PNAS 2005 102:4741-4746; published ahead of print March 17, 2005, doi:10.1073/pnas.0501043102
  • Biological Sciences - Biophysics:
    • J. Zamoon,
    • F. Nitu,
    • C. Karim,
    • D. D. Thomas,
    • and G. Veglia

    Mapping the interaction surface of a membrane protein: Unveiling the conformational switch of phospholamban in calcium pump regulation

    PNAS 2005 102:4747-4752; published ahead of print March 21, 2005, doi:10.1073/pnas.0406039102
  • Biological Sciences - Biophysics:
    • Margaret S. Cheung,
    • Dmitri Klimov,
    • and D. Thirumalai

    Molecular crowding enhances native state stability and refolding rates of globular proteins

    PNAS 2005 102:4753-4758; published ahead of print March 21, 2005, doi:10.1073/pnas.0409630102
  • Biological Sciences - Biophysics:
    • Tomoyo Sakata,
    • Yuling Yan,
    • and Gerard Marriott

    Optical switching of dipolar interactions on proteins

    PNAS 2005 102:4759-4764; published ahead of print March 16, 2005, doi:10.1073/pnas.0405265102
  • Biological Sciences - Biophysics:
    • Chiaki Nishimura,
    • H. Jane Dyson,
    • and Peter E. Wright

    Enhanced picture of protein-folding intermediates using organic solvents in H/D exchange and quench-flow experiments

    PNAS 2005 102:4765-4770; published ahead of print March 15, 2005, doi:10.1073/pnas.0409538102
  • Biological Sciences - Biophysics:
    • Sandeep Krishna,
    • Bidisha Banerjee,
    • T. V. Ramakrishnan,
    • and G. V. Shivashankar

    Stochastic simulations of the origins and implications of long-tailed distributions in gene expression

    PNAS 2005 102:4771-4776; published ahead of print March 16, 2005, doi:10.1073/pnas.0406415102

Cell Biology

  • Biological Sciences - Cell Biology:
    • Xiaolan Zhao
    • and Günter Blobel

    From the Cover: A SUMO ligase is part of a nuclear multiprotein complex that affects DNA repair and chromosomal organization

    PNAS 2005 102:4777-4782; published ahead of print February 28, 2005, doi:10.1073/pnas.0500537102
    • See commentary article on page 4661 in issue 13 of volume 102

Developmental Biology

  • Biological Sciences - Developmental Biology:
    • Toshihiko Ezashi,
    • Padmalaya Das,
    • and R. Michael Roberts

    Low O 2 tensions and the prevention of differentiation of hES cells

    PNAS 2005 102:4783-4788; published ahead of print March 16, 2005, doi:10.1073/pnas.0501283102
  • Biological Sciences - Developmental Biology:
    • Takako Kondo,
    • Scott A. Johnson,
    • Mervin C. Yoder,
    • Raymond Romand,
    • and Eri Hashino

    From the Cover: Sonic hedgehog and retinoic acid synergistically promote sensory fate specification from bone marrow-derived pluripotent stem cells

    PNAS 2005 102:4789-4794; published ahead of print March 18, 2005, doi:10.1073/pnas.0408239102

Genetics

  • Biological Sciences - Genetics:
    • Elliott H. Margulies,
    • Jade P. Vinson,
    • NISC Comparative Sequencing Program,
    • Webb Miller,
    • David B. Jaffe,
    • Kerstin Lindblad-Toh,
    • Jean L. Chang,
    • Eric D. Green,
    • Eric S. Lander,
    • James C. Mullikin,
    • and Michele Clamp

    An initial strategy for the systematic identification of functional elements in the human genome by low-redundancy comparative sequencing

    PNAS 2005 102:4795-4800; published ahead of print March 18, 2005, doi:10.1073/pnas.0409882102
  • Biological Sciences - Genetics:
    • J. Perren Cobb,
    • Michael N. Mindrinos,
    • Carol Miller-Graziano,
    • Steve E. Calvano,
    • Henry V. Baker,
    • Wenzhong Xiao,
    • Krzysztof Laudanski,
    • Bernard H. Brownstein,
    • Constance M. Elson,
    • Douglas L. Hayden,
    • David N. Herndon,
    • Stephen F. Lowry,
    • Ronald V. Maier,
    • David A. Schoenfeld,
    • Lyle L. Moldawer,
    • Ronald W. Davis,
    • Ronald G. Tompkins,
    • and Inflammation and Host Response to Injury Large-Scale Collaborative Research Program

    Application of genome-wide expression analysis to human health and disease

    PNAS 2005 102:4801-4806; published ahead of print March 21, 2005, doi:10.1073/pnas.0409768102
  • Biological Sciences - Genetics:
    • Bernadette Neve,
    • Martin E. Fernandez-Zapico,
    • Vered Ashkenazi-Katalan,
    • Christian Dina,
    • Yasmin H. Hamid,
    • Erik Joly,
    • Emmanuel Vaillant,
    • Yamina Benmezroua,
    • Emmanuelle Durand,
    • Nicolas Bakaher,
    • Valerie Delannoy,
    • Martine Vaxillaire,
    • Tiffany Cook,
    • Geesje M. Dallinga-Thie,
    • Hans Jansen,
    • Marie-Aline Charles,
    • Karine Clément,
    • Pilar Galan,
    • Serge Hercberg,
    • Nicole Helbecque,
    • Guillaume Charpentier,
    • Marc Prentki,
    • Torben Hansen,
    • Oluf Pedersen,
    • Raul Urrutia,
    • Danielle Melloul,
    • and Philippe Froguel

    From the Cover: Role of transcription factor KLF11 and its diabetes-associated gene variants in pancreatic beta cell function

    PNAS 2005 102:4807-4812; published ahead of print March 17, 2005, doi:10.1073/pnas.0409177102
  • Biological Sciences - Genetics:
    • Jiguo Chen
    • and Ivan Sadowski

    Identification of the mismatch repair genes PMS2 and MLH1 as p53 target genes by using serial analysis of binding elements

    PNAS 2005 102:4813-4818; published ahead of print March 21, 2005, doi:10.1073/pnas.0407069102

Immunology

  • Biological Sciences - Immunology:
    • Massimo Morra,
    • Robert A. Barrington,
    • Ana C. Abadia-Molina,
    • Susumo Okamoto,
    • Aimee Julien,
    • Charles Gullo,
    • Anuj Kalsy,
    • Matthew J. Edwards,
    • Gang Chen,
    • Rosanne Spolski,
    • Warren J. Leonard,
    • Brigitte T. Huber,
    • Persephone Borrow,
    • Christine A. Biron,
    • Abhay R. Satoskar,
    • Michael C. Carroll,
    • and Cox Terhorst

    Defective B cell responses in the absence of SH2D1A

    PNAS 2005 102:4819-4823; published ahead of print March 17, 2005, doi:10.1073/pnas.0408681102
  • Biological Sciences - Immunology:
    • Pablo A. González,
    • Leandro J. Carreño,
    • Daniel Coombs,
    • Jorge E. Mora,
    • Edith Palmieri,
    • Byron Goldstein,
    • Stanley G. Nathenson,
    • and Alexis M. Kalergis

    T cell receptor binding kinetics required for T cell activation depend on the density of cognate ligand on the antigen-presenting cell

    PNAS 2005 102:4824-4829; published ahead of print March 16, 2005, doi:10.1073/pnas.0500922102
  • Biological Sciences - Immunology:
    • Chun Kim,
    • Nadesan Gajendran,
    • Hans-Willi Mittrücker,
    • Matthias Weiwad,
    • Young-Hwa Song,
    • Robert Hurwitz,
    • Matthias Wilmanns,
    • Gunter Fischer,
    • and Stefan H. E. Kaufmann

    Human α-defensins neutralize anthrax lethal toxin and protect against its fatal consequences

    PNAS 2005 102:4830-4835; published ahead of print March 16, 2005, doi:10.1073/pnas.0500508102

Medical Sciences

  • Biological Sciences - Medical Sciences:
    • Daniel P. Webster,
    • Susanna Dunachie,
    • Jenni M. Vuola,
    • Tamara Berthoud,
    • Sheila Keating,
    • Stephen M. Laidlaw,
    • Samuel J. McConkey,
    • Ian Poulton,
    • Laura Andrews,
    • Rikke F. Andersen,
    • Philip Bejon,
    • Geoff Butcher,
    • Robert Sinden,
    • Michael A. Skinner,
    • Sarah C. Gilbert,
    • and Adrian V. S. Hill

    Enhanced T cell-mediated protection against malaria in human challenges by using the recombinant poxviruses FP9 and modified vaccinia virus Ankara

    PNAS 2005 102:4836-4841; published ahead of print March 21, 2005, doi:10.1073/pnas.0406381102
  • Biological Sciences - Medical Sciences:
    • Chitra Subramanian,
    • Anthony W. Opipari, Jr.,
    • Xin Bian,
    • Valerie P. Castle,
    • and Roland P. S. Kwok

    Ku70 acetylation mediates neuroblastoma cell death induced by histone deacetylase inhibitors

    PNAS 2005 102:4842-4847; published ahead of print March 18, 2005, doi:10.1073/pnas.0408351102
  • Biological Sciences - Medical Sciences:
    • Richard Malley,
    • Krzysztof Trzcinski,
    • Amit Srivastava,
    • Claudette M. Thompson,
    • Porter W. Anderson,
    • and Marc Lipsitch

    CD4 + T cells mediate antibody-independent acquired immunity to pneumococcal colonization

    PNAS 2005 102:4848-4853; published ahead of print March 21, 2005, doi:10.1073/pnas.0501254102
  • Biological Sciences - Medical Sciences:
    • Katarzyna E. Kolodziejska,
    • Alan R. Burns,
    • Robert H. Moore,
    • David L. Stenoien,
    • and N. Tony Eissa

    Regulation of inducible nitric oxide synthase by aggresome formation

    PNAS 2005 102:4854-4859; published ahead of print March 21, 2005, doi:10.1073/pnas.0500485102

Microbiology

  • Biological Sciences - Microbiology:
    • Largus T. Angenent,
    • Scott T. Kelley,
    • Allison St. Amand,
    • Norman R. Pace,
    • and Mark T. Hernandez

    Molecular identification of potential pathogens in water and air of a hospital therapy pool

    PNAS 2005 102:4860-4865; published ahead of print March 15, 2005, doi:10.1073/pnas.0501235102
  • Biological Sciences - Microbiology:
    • Nadim Shohdy,
    • Jem A. Efe,
    • Scott D. Emr,
    • and Howard A. Shuman

    Pathogen effector protein screening in yeast identifies Legionella factors that interfere with membrane trafficking

    PNAS 2005 102:4866-4871; published ahead of print March 21, 2005, doi:10.1073/pnas.0501315102

Neuroscience

  • Biological Sciences - Neuroscience:
    • M