Commentary

  • Commentary:
    • Graciela Spivak

    The many faces of Cockayne syndrome

    PNAS 2004 101:15273-15274; published ahead of print October 19, 2004, doi:10.1073/pnas.0406894101
    • See companion article on page 15410 in issue 43 of volume 101

Physical Sciences

Chemistry

  • Physical Sciences - Chemistry:
    • Robert M. Dirks
    • and Niles A. Pierce

    From the Cover: Triggered amplification by hybridization chain reaction

    PNAS 2004 101:15275-15278; published ahead of print October 18, 2004, doi:10.1073/pnas.0407024101
  • Physical Sciences - Chemistry:
    • Antoine Richard,
    • Valérie Marchi-Artzner,
    • Marie-Noëlle Lalloz,
    • Marie-Josèphe Brienne,
    • Franck Artzner,
    • Thaddée Gulik-Krzywicki,
    • Marie-Alice Guedeau-Boudeville,
    • and Jean-Marie Lehn

    Fusogenic supramolecular vesicle systems induced by metal ion binding to amphiphilic ligands

    PNAS 2004 101:15279-15284; published ahead of print October 18, 2004, doi:10.1073/pnas.0406625101

Geology

  • Physical Sciences - Geology:
    • Oliver Heiri,
    • Willy Tinner,
    • and André F. Lotter

    Evidence for cooler European summers during periods of changing meltwater flux to the North Atlantic

    PNAS 2004 101:15285-15288; published ahead of print October 18, 2004, doi:10.1073/pnas.0406594101

Biological Sciences

Agricultural Sciences

  • Biological Sciences - Agricultural Sciences:
    • Hong-Kyu Choi,
    • Jeong-Hwan Mun,
    • Dong-Jin Kim,
    • Hongyan Zhu,
    • Jong-Min Baek,
    • Joanne Mudge,
    • Bruce Roe,
    • Noel Ellis,
    • Jeff Doyle,
    • Gyorgy B. Kiss,
    • Nevin D. Young,
    • and Douglas R. Cook

    Estimating genome conservation between crop and model legume species

    PNAS 2004 101:15289-15294; published ahead of print October 15, 2004, doi:10.1073/pnas.0402251101

Applied Biological Sciences

  • Biological Sciences - Applied Biological Sciences:
    • Frauke Rininsland,
    • Wensheng Xia,
    • Shannon Wittenburg,
    • Xiaobo Shi,
    • Casey Stankewicz,
    • Komandoor Achyuthan,
    • Duncan McBranch,
    • and David Whitten

    Metal ion-mediated polymer superquenching for highly sensitive detection of kinase and phosphatase activities

    PNAS 2004 101:15295-15300; published ahead of print October 19, 2004, doi:10.1073/pnas.0406832101

Biochemistry

  • Biological Sciences - Biochemistry:
    • Tímea Gérczei
    • and Carl C. Correll

    Imp3p and Imp4p mediate formation of essential U3–precursor rRNA (pre-rRNA) duplexes, possibly to recruit the small subunit processome to the pre-rRNA

    PNAS 2004 101:15301-15306; published ahead of print October 15, 2004, doi:10.1073/pnas.0406819101
  • Biological Sciences - Biochemistry:
    • Timothy A. Fritz,
    • James H. Hurley,
    • Loc-Ba Trinh,
    • Joseph Shiloach,
    • and Lawrence A. Tabak

    The beginnings of mucin biosynthesis: The crystal structure of UDP-GalNAc:polypeptide α- N -acetylgalactosaminyltransferase-T1

    PNAS 2004 101:15307-15312; published ahead of print October 14, 2004, doi:10.1073/pnas.0405657101
  • Biological Sciences - Biochemistry:
    • Hisashi Harada,
    • Bonnie Quearry,
    • Antonio Ruiz-Vela,
    • and Stanley J. Korsmeyer

    Survival factor-induced extracellular signal-regulated kinase phosphorylates BIM, inhibiting its association with BAX and proapoptotic activity

    PNAS 2004 101:15313-15317; published ahead of print October 14, 2004, doi:10.1073/pnas.0406837101
  • Biological Sciences - Biochemistry:
    • Chee-Kwee Ea,
    • Lijun Sun,
    • Jun-Ichiro Inoue,
    • and Zhijian J. Chen

    TIFA activates IκB kinase (IKK) by promoting oligomerization and ubiquitination of TRAF6

    PNAS 2004 101:15318-15323; published ahead of print October 18, 2004, doi:10.1073/pnas.0404132101

Biophysics

  • Biological Sciences - Biophysics:
    • Başar Bilgiçer
    • and Krishna Kumar

    From the Cover: De novo design of defined helical bundles in membrane environments

    PNAS 2004 101:15324-15329; published ahead of print October 14, 2004, doi:10.1073/pnas.0403314101
  • Biological Sciences - Biophysics:
    • Gerhard Hummer,
    • Friedrich Schotte,
    • and Philip A. Anfinrud

    Unveiling functional protein motions with picosecond x-ray crystallography and molecular dynamics simulations

    PNAS 2004 101:15330-15334; published ahead of print October 15, 2004, doi:10.1073/pnas.0405295101
  • Biological Sciences - Biophysics:
    • Ruxandra I. Dima
    • and D. Thirumalai

    Probing the instabilities in the dynamics of helical fragments from mouse PrP C

    PNAS 2004 101:15335-15340; published ahead of print October 19, 2004, doi:10.1073/pnas.0404235101
  • Biological Sciences - Biophysics:
    • Christoph H. Borchers,
    • Victor E. Marquez,
    • Gottfried K. Schroeder,
    • Steven A. Short,
    • Mark J. Snider,
    • J. Paul Speir,
    • and Richard Wolfenden

    Fourier transform ion cyclotron resonance MS reveals the presence of a water molecule in an enzyme transition-state analogue complex

    PNAS 2004 101:15341-15345; published ahead of print October 19, 2004, doi:10.1073/pnas.0406781101
  • Biological Sciences - Biophysics:
    • Bin Qian,
    • Angel R. Ortiz,
    • and David Baker

    Improvement of comparative model accuracy by free-energy optimization along principal components of natural structural variation

    PNAS 2004 101:15346-15351; published ahead of print October 18, 2004, doi:10.1073/pnas.0404703101
  • Biological Sciences - Biophysics:
    • Kang Chen,
    • Zhigang Liu,
    • and Neville R. Kallenbach

    The polyproline II conformation in short alanine peptides is noncooperative

    PNAS 2004 101:15352-15357; published ahead of print October 15, 2004, doi:10.1073/pnas.0406657101

Cell Biology

  • Biological Sciences - Cell Biology:
    • Megan Cully,
    • Andrew Elia,
    • Siew-Hwa Ong,
    • Vuk Stambolic,
    • Tony Pawson,
    • Ming-Sound Tsao,
    • and Tak W. Mak

    grb2 heterozygosity rescues embryonic lethality but not tumorigenesis in pten +/- mice

    PNAS 2004 101:15358-15363; published ahead of print October 18, 2004, doi:10.1073/pnas.0406613101
  • Biological Sciences - Cell Biology:
    • Marcel Tuynder,
    • Giusy Fiucci,
    • Sylvie Prieur,
    • Alexandra Lespagnol,
    • Anne Géant,
    • Séverine Beaucourt,
    • Dominique Duflaut,
    • Stéphanie Besse,
    • Laurent Susini,
    • Jean Cavarelli,
    • Dino Moras,
    • Robert Amson,
    • and Adam Telerman

    Translationally controlled tumor protein is a target of tumor reversion

    PNAS 2004 101:15364-15369; published ahead of print October 15, 2004, doi:10.1073/pnas.0406776101

Developmental Biology

  • Biological Sciences - Developmental Biology:
    • Qiang Tian,
    • Megan C. Feetham,
    • W. Andy Tao,
    • Xi C. He,
    • Linheng Li,
    • Ruedi Aebersold,
    • and Leroy Hood

    Proteomic analysis identifies that 14-3-3ζ interacts with β-catenin and facilitates its activation by Akt

    PNAS 2004 101:15370-15375; published ahead of print October 18, 2004, doi:10.1073/pnas.0406499101

Evolution

  • Biological Sciences - Evolution:
    • Rafael Sanjuán,
    • Andrés Moya,
    • and Santiago F. Elena

    The contribution of epistasis to the architecture of fitness in an RNA virus

    PNAS 2004 101:15376-15379; published ahead of print October 18, 2004, doi:10.1073/pnas.0404125101
  • Biological Sciences - Evolution:
    • Patrick J. Keeling
    • and Yuji Inagaki

    A class of eukaryotic GTPase with a punctate distribution suggesting multiple functional replacements of translation elongation factor 1α

    PNAS 2004 101:15380-15385; published ahead of print October 18, 2004, doi:10.1073/pnas.0404505101
  • Biological Sciences - Evolution:
    • Emmanuel J. P. Douzery,
    • Elizabeth A. Snell,
    • Eric Bapteste,
    • Frédéric Delsuc,
    • and Hervé Philippe

    The timing of eukaryotic evolution: Does a relaxed molecular clock reconcile proteins and fossils?

    PNAS 2004 101:15386-15391; published ahead of print October 19, 2004, doi:10.1073/pnas.0403984101

Genetics

  • Biological Sciences - Genetics:
    • Lance D. Langston
    • and Lorraine S. Symington

    Gene targeting in yeast is initiated by two independent strand invasions

    PNAS 2004 101:15392-15397; published ahead of print October 15, 2004, doi:10.1073/pnas.0403748101
  • Biological Sciences - Genetics:
    • Paul D. Thomas
    • and Anish Kejariwal

    Coding single-nucleotide polymorphisms associated with complex vs. Mendelian disease: Evolutionary evidence for differences in molecular effects

    PNAS 2004 101:15398-15403; published ahead of print October 18, 2004, doi:10.1073/pnas.0404380101
  • Biological Sciences - Genetics:
    • Ji-Ming Gong,
    • David A. Waner,
    • Tomoaki Horie,
    • Shi Lun Li,
    • Rie Horie,
    • Khush B. Abid,
    • and Julian I. Schroeder

    Microarray-based rapid cloning of an ion accumulation deletion mutant in Arabidopsis thaliana

    PNAS 2004 101:15404-15409; published ahead of print October 14, 2004, doi:10.1073/pnas.0404780101
  • Biological Sciences - Genetics:
    • Katsuyoshi Horibata,
    • Yuka Iwamoto,
    • Isao Kuraoka,
    • Nicolaas G. J. Jaspers,
    • Akihiro Kurimasa,
    • Mitsuo Oshimura,
    • Masamitsu Ichihashi,
    • and Kiyoji Tanaka

    From the Cover: Complete absence of Cockayne syndrome group B gene product gives rise to UV-sensitive syndrome but not Cockayne syndrome

    PNAS 2004 101:15410-15415; published ahead of print October 14, 2004, doi:10.1073/pnas.0404587101
    • See commentary article on page 15273 in issue 43 of volume 101

Immunology

  • Biological Sciences - Immunology:
    • Kenya Honda,
    • Hideyuki Yanai,
    • Tatsuaki Mizutani,
    • Hideo Negishi,
    • Naoya Shimada,
    • Nobutaka Suzuki,
    • Yusuke Ohba,
    • Akinori Takaoka,
    • Wen-Chen Yeh,
    • and Tadatsugu Taniguchi

    Role of a transductional-transcriptional processor complex involving MyD88 and IRF-7 in Toll-like receptor signaling

    PNAS 2004 101:15416-15421; published ahead of print October 18, 2004, doi:10.1073/pnas.0406933101
  • Biological Sciences - Immunology:
    • Can Xie,
    • Motomu Shimaoka,
    • Tsan Xiao,
    • Pascale Schwab,
    • Lloyd B. Klickstein,
    • and Timothy A. Springer

    The integrin α-subunit leg extends at a Ca 2+ -dependent epitope in the thigh/genu interface upon activation

    PNAS 2004 101:15422-15427; published ahead of print October 19, 2004, doi:10.1073/pnas.0406680101
  • Biological Sciences - Immunology:
    • Ziqiang Li,
    • Zhonghui Luo,
    • and Matthew D. Scharff

    Differential regulation of histone acetylation and generation of mutations in switch regions is associated with Ig class switching

    PNAS 2004 101:15428-15433; published ahead of print October 14, 2004, doi:10.1073/pnas.0406827101
  • Biological Sciences - Immunology:
    • Jayagopala Reddy,
    • Zsolt Illes,
    • Xingmin Zhang,
    • Jeffrey Encinas,
    • Jason Pyrdol,
    • Lindsay Nicholson,
    • Raymond A. Sobel,
    • Kai W. Wucherpfennig,
    • and Vijay K. Kuchroo

    Myelin proteolipid protein-specific CD4 + CD25 + regulatory cells mediate genetic resistance to experimental autoimmune encephalomyelitis

    PNAS 2004 101:15434-15439; published ahead of print October 18, 2004, doi:10.1073/pnas.0404444101
  • Biological Sciences - Immunology:
    • David C. Jackson,
    • Yuk Fai Lau,
    • Thuy Le,
    • Andreas Suhrbier,
    • Georgia Deliyannis,
    • Christina Cheers,
    • Corey Smith,
    • Weiguang Zeng,
    • and Lorena E. Brown

    A totally synthetic vaccine of generic structure that targets Toll-like receptor 2 on dendritic cells and promotes antibody or cytotoxic T cell responses

    PNAS 2004 101:15440-15445; published ahead of print October 15, 2004, doi:10.1073/pnas.0406740101

Medical Sciences

  • Biological Sciences - Medical Sciences:
    • Danielle L. Krebs,
    • Donald Metcalf,
    • Tobias D. Merson,
    • Anne K. Voss,
    • Tim Thomas,
    • Jian-Guo Zhang,
    • Steven Rakar,
    • Moira K. O'Bryan,
    • Tracy A. Willson,
    • Elizabeth M. Viney,
    • Lisa A. Mielke,
    • Nicos A. Nicola,
    • Douglas J. Hilton,
    • and Warren S. Alexander

    Development of hydrocephalus in mice lacking SOCS7

    PNAS 2004 101:15446-15451; published ahead of print October 19, 2004, doi:10.1073/pnas.0406870101
  • Biological Sciences - Medical Sciences:
    • Catherine M. Finnegan,
    • Satinder S. Rawat,
    • Anu Puri,
    • Ji Ming Wang,
    • Francis W. Ruscetti,
    • and Robert Blumenthal

    Ceramide, a target for antiretroviral therapy

    PNAS 2004 101:15452-15457; published ahead of print October 15, 2004, doi:10.1073/pnas.0402874101
  • Biological Sciences - Medical Sciences:
    • Henri J. Vial,
    • Sharon Wein,
    • Christine Farenc,
    • Clemens Kocken,
    • Olivier Nicolas,
    • Marie Laure Ancelin,
    • Francoise Bressolle,
    • Alan Thomas,
    • and Michèle Calas

    Prodrugs of bisthiazolium salts are orally potent antimalarials

    PNAS 2004 101:15458-15463; published ahead of print October 18, 2004, doi:10.1073/pnas.0404037101
  • Biological Sciences - Medical Sciences:
    • Claire Vandiedonck,
    • Geneviève Beaurain,
    • Matthieu Giraud,
    • Catherine Hue-Beauvais,
    • Bruno Eymard,
    • Christine Tranchant,
    • Philippe Gajdos,
    • Jean Dausset,
    • and Henri-Jean Garchon

    Pleiotropic effects of the 8.1 HLA haplotype in patients with autoimmune myasthenia gravis and thymus hyperplasia

    PNAS 2004 101:15464-15469; published ahead of print October 15, 2004, doi:10.1073/pnas.0406756101

Microbiology

  • Biological Sciences - Microbiology:
    • Adam L. Feire,
    • Heidi Koss,
    • and Teresa Compton

    Cellular integrins function as entry receptors for human cytomegalovirus via a highly conserved disintegrin-like domain

    PNAS 2004 101:15470-15475; published ahead of print October 19, 2004, doi:10.1073/pnas.0406821101

Neuroscience

  • Biological Sciences - Neuroscience:
    • Flavia Troglio,
    • Cinara Echart,
    • Alberto Gobbi,
    • Tony Pawson,
    • Pier Giuseppe Pelicci,
    • Maria Grazia De Simoni,
    • and Giuliana Pelicci

    From the Cover: The Rai (Shc C) adaptor protein regulates the neuronal stress response and protects against cerebral ischemia

    PNAS 2004 101:15476-15481; published ahead of print October 19, 2004, doi:10.1073/pnas.0403283101
  • Biological Sciences - Neuroscience:
    • Nancy Kopell
    • and Bard Ermentrout

    Chemical and electrical synapses perform complementary roles in the synchronization of interneuronal networks

    PNAS 2004 101:15482-15487; published ahead of print October 15, 2004, doi:10.1073/pnas.0406343101
  • Biological Sciences - Neuroscience:
    • W.-C. Li,
    • S. R. Soffe,
    • and Alan Roberts

    From the Cover: Glutamate and acetylcholine corelease at developing synapses

    PNAS 2004 101:15488-15493; published ahead of print October 19, 2004, doi:10.1073/pnas.0404864101
  • Biological Sciences - Neuroscience:
    • Sebastian Brauchi,
    • Patricio Orio,
    • and Ramon Latorre

    Clues to understanding cold sensation: Thermodynamics and electrophysiological analysis of the cold receptor TRPM8

    PNAS 2004 101:15494-15499; published ahead of print October 18, 2004, doi:10.1073/pnas.0406773101
  • Biological Sciences - Neuroscience: