Table of Contents

• Mahesh Anand,
• Lawrence A. Taylor,
• Mikhail A. Nazarov,
• J. Shu,
• H.-K. Mao,
• and Russell J. Hemley

Space weathering on airless planetary bodies: Clues from the lunar mineral hapkeite

• Sylvestre Marillonnet,
• Anatoli Giritch,
• Mario Gils,
• Romy Kandzia,
• Victor Klimyuk,
• and Yuri Gleba

In planta engineering of viral RNA replicons: Efficient assembly by recombination of DNA modules delivered by Agrobacterium

• Ludger Grosse-Hovest,
• Sigrid Müller,
• Rosa Minoia,
• Eckhard Wolf,
• Valeri Zakhartchenko,
• Hendrik Wenigerkind,
• Caroline Lassnig,
• Urban Besenfelder,
• Mathias Müller,
• Simon D. Lytton,
• Gundram Jung,
• and Gottfried Brem

Cloned transgenic farm animals produce a bispecific antibody for T cell-mediated tumor cell killing

• Alan B. Marnett,
• Anson M. Nomura,
• Nobuhisa Shimba,
• Paul R. Ortiz de Montellano,
• and Charles S. Craik

Communication between the active sites and dimer interface of a herpesvirus protease revealed by a transition-state inhibitor

• Chawnshang Chang,
• Yen-Ta Chen,
• Shauh-Der Yeh,
• Qingquan Xu,
• Ruey-Sheng Wang,
• Florian Guillou,
• Henry Lardy,
• and Shuyuan Yeh

Infertility with defective spermatogenesis and hypotestosteronemia in male mice lacking the androgen receptor in Sertoli cells

• Michelle C. Y. Chang,
• Cyril S. Yee,
• JoAnne Stubbe,
• and Daniel G. Nocera

Turning on ribonucleotide reductase by light-initiated amino acid radical generation

• Brent Segelke,
• Mark Knapp,
• Saloumeh Kadkhodayan,
• Rod Balhorn,
• and Bernhard Rupp

Crystal structure of Clostridium botulinum neurotoxin protease in a product-bound state: Evidence for noncanonical zinc protease activity

• Nick Shkriabai,
• Sachindra S. Patil,
• Sonja Hess,
• Scott R. Budihas,
• Robert Craigie,
• Terrence R. Burke, Jr.,
• Stuart F. J. Le Grice,
• and Mamuka Kvaratskhelia

Identification of an inhibitor-binding site to HIV-1 integrase with affinity acetylation and mass spectrometry

• Lori A. Plum,
• Jean M. Prahl,
• Xiaohong Ma,
• Rafal R. Sicinski,
• Sumithra Gowlugari,
• Margaret Clagett-Dame,
• and Hector F. DeLuca

Biologically active noncalcemic analogs of 1α,25-dihydroxyvitamin D with an abbreviated side chain containing no hydroxyl

• Aghdass Rasouli-Nia,
• Feridoun Karimi-Busheri,
• and Michael Weinfeld

Stable down-regulation of human polynucleotide kinase enhances spontaneous mutation frequency and sensitizes cells to genotoxic agents

• Mofang Liu,
• Michael Tolstorukov,
• Victor Zhurkin,
• Susan Garges,
• and Sankar Adhya

A mutant spacer sequence between -35 and -10 elements makes the P lac promoter hyperactive and cAMP receptor protein-independent

• Eric M. Tam,
• Charlotte J. Morrison,
• Yi I. Wu,
• M. Sharon Stack,
• and Christopher M. Overall

Membrane protease proteomics: Isotope-coded affinity tag MS identification of undescribed MT1–matrix metalloproteinase substrates

• María Gómez
• and Neil Brockdorff

Heterochromatin on the inactive X chromosome delays replication timing without affecting origin usage

• Sherry D. Painter,
• Scott F. Cummins,
• Amy E. Nichols,
• David-B. G. Akalal,
• Catherine H. Schein,
• Werner Braun,
• John S. Smith,
• Abraham J. Susswein,
• Miriam Levy,
• Pamela A. C. M. de Boer,
• Andries ter Maat,
• Mark W. Miller,
• Cory Scanlan,
• Richard M. Milberg,
• Jonathan V. Sweedler,
• and Gregg T. Nagle

Structural and functional analysis of Aplysia attractins, a family of water-borne protein pheromones with interspecific attractiveness

• Xiaochun Fan,
• Hua Shi,
• Karen Adelman,
• and John T. Lis

Probing TBP interactions in transcription initiation and reinitiation with RNA aptamers that act in distinct modes

• Alexandre V. Morozov,
• Tanja Kortemme,
• Kiril Tsemekhman,
• and David Baker

Close agreement between the orientation dependence of hydrogen bonds observed in protein structures and quantum mechanical calculations

• Marc Delarue
• and Philippe Dumas

On the use of low-frequency normal modes to enforce collective movements in refining macromolecular structural models

• C. P. Johnson,
• I. Fujimoto,
• C. Perrin-Tricaud,
• U. Rutishauser,
• and D. Leckband

Mechanism of homophilic adhesion by the neural cell adhesion molecule: Use of multiple domains and flexibility

• John van Noort,
• Sander Verbrugge,
• Nora Goosen,
• Cees Dekker,
• and Remus Thei Dame

Dual architectural roles of HU: Formation of flexible hinges and rigid filaments

• Anne Aries,
• Pierre Paradis,
• Chantal Lefebvre,
• Robert J. Schwartz,
• and Mona Nemer

Essential role of GATA-4 in cell survival and drug-induced cardiotoxicity

• Tomas Vomastek,
• Hans-Joerg Schaeffer,
• Adel Tarcsafalvi,
• Mark E. Smolkin,
• Eric A. Bissonette,
• and Michael J. Weber

Modular construction of a signaling scaffold: MORG1 interacts with components of the ERK cascade and links ERK signaling to specific agonists

• Alexandra Fridkin,
• Erez Mills,
• Ayelet Margalit,
• Esther Neufeld,
• Kenneth K. Lee,
• Naomi Feinstein,
• Merav Cohen,
• Katherine L. Wilson,
• and Yosef Gruenbaum

Matefin, a Caenorhabditis elegans germ line-specific SUN-domain nuclear membrane protein, is essential for early embryonic and germ cell development

• Jee-Yin Ahn,
• Yuanxin Hu,
• Todd G. Kroll,
• Paulette Allard,
• and Keqiang Ye

PIKE-A is amplified in human cancers and prevents apoptosis by up-regulating Akt

• Brian G. Drew,
• Noel H. Fidge,
• Gabrielle Gallon-Beaumier,
• Bruce E. Kemp,
• and Bronwyn A. Kingwell

High-density lipoprotein and apolipoprotein AI increase endothelial NO synthase activity by protein association and multisite phosphorylation

• Mariko Katoh,
• Chad Shaw,
• Qikai Xu,
• Nancy Van Driessche,
• Takahiro Morio,
• Hidekazu Kuwayama,
• Shinji Obara,
• Hideko Urushihara,
• Yoshimasa Tanaka,
• and Gad Shaulsky

An orderly retreat: Dedifferentiation is a regulated process

• Joshua A. Bittker,
• Brian V. Le,
• Jane M. Liu,
• and David R. Liu

Directed evolution of protein enzymes using nonhomologous random recombination

• Natalia L. Komarova
• and Dominik Wodarz

The optimal rate of chromosome loss for the inactivation of tumor suppressor genes in cancer

• Jeffrey O. Bush,
• Yu Lan,
• and Rulang Jiang

The cleft lip and palate defects in Dancer mutant mice result from gain of function of the Tbx10 gene

• AeRi Kim
• and Ann Dean

Developmental stage differences in chromatin subdomains of the β-globin locus

• J. H. F. Pedra,
• L. M. McIntyre,
• M. E. Scharf,
• and Barry R. Pittendrigh

Genome-wide transcription profile of field- and laboratory-selected dichlorodiphenyltrichloroethane (DDT)-resistant Drosophila

• Z. W. Luo,
• R. M. Zhang,
• and M. J. Kearsey

Theoretical basis for genetic linkage analysis in autotetraploid species

• Magnus Lundgren,
• Anders Andersson,
• Lanming Chen,
• Peter Nilsson,
• and Rolf Bernander

Three replication origins in Sulfolobus species: Synchronous initiation of chromosome replication and asynchronous termination

• Andreas Villunger,
• Vanessa S. Marsden,
• Yifan Zhan,
• Miriam Erlacher,
• Andrew M. Lew,
• Philippe Bouillet,
• Stuart Berzins,
• Dale I. Godfrey,
• William R. Heath,
• and Andreas Strasser

Negative selection of semimature CD4 + 8 - HSA + thymocytes requires the BH3-only protein Bim but is independent of death receptor signaling

• Johan K. Sandberg,
• Cheryl A. Stoddart,
• Fabienne Brilot,
• Kimberly A. Jordan,
• and