Commentary

  • Commentary:
    • Yaakov Levy
    • and José N. Onuchic

    Water and proteins: A love–hate relationship

    PNAS 2004 101:3325-3326; published ahead of print March 1, 2004, doi:10.1073/pnas.0400157101
    • See companion article on page 3352 in issue 10 of volume 101

Biography

  • Biography:
    • David Bradley

    Inaugural Article: Biography of Lewis C. Cantley

    PNAS 2004 101:3327-3328; published ahead of print March 1, 2004, doi:10.1073/pnas.0400872101
    • See commentary article on page 3329 in issue 10 of volume 101
  • Biography:
    • Christen Brownlee

    Inaugural Article: Biography of Stephen J. Elledge

    PNAS 2004 101:3336-3337; published ahead of print March 1, 2004, doi:10.1073/pnas.0400868101
    • See commentary article on page 3338 in issue 10 of volume 101

Physical Sciences

Applied Physical Sciences

  • Physical Sciences - Applied Physical Sciences - Biological Sciences - Applied Biological Sciences:
    • Stephan Thiberge,
    • Amotz Nechushtan,
    • David Sprinzak,
    • Opher Gileadi,
    • Vered Behar,
    • Ory Zik,
    • Yehuda Chowers,
    • Shulamit Michaeli,
    • Joseph Schlessinger,
    • and Elisha Moses

    Scanning electron microscopy of cells and tissues under fully hydrated conditions

    PNAS 2004 101:3346-3351; published ahead of print February 26, 2004, doi:10.1073/pnas.0400088101

Chemistry

  • Physical Sciences - Chemistry:
    • Garegin A. Papoian,
    • Johan Ulander,
    • Michael P. Eastwood,
    • Zaida Luthey-Schulten,
    • and Peter G. Wolynes

    From the Cover: Water in protein structure prediction

    PNAS 2004 101:3352-3357; published ahead of print February 26, 2004, doi:10.1073/pnas.0307851100
    • See commentary article on page 3325 in issue 10 of volume 101
  • Physical Sciences - Chemistry - Biological Sciences - Biochemistry:
    • Lei Zheng,
    • Ulrich Baumann,
    • and Jean-Louis Reymond

    Molecular mechanism of enantioselective proton transfer to carbon in catalytic antibody 14D9

    PNAS 2004 101:3387-3392; published ahead of print February 26, 2004, doi:10.1073/pnas.0400263101

Physics

  • Physical Sciences - Physics:
    • Joanna Aizenberg,
    • Vikram C. Sundar,
    • Andrew D. Yablon,
    • James C. Weaver,
    • and Gang Chen

    Biological glass fibers: Correlation between optical and structural properties

    PNAS 2004 101:3358-3363; published ahead of print March 1, 2004, doi:10.1073/pnas.0307843101

Social Sciences

Economic Sciences

  • Social Sciences - Economic Sciences:
    • Douglas A. Hibbs, Jr.
    • and Ola Olsson

    Geography, biogeography, and why some countries are rich and others are poor

    PNAS 2004 101:3715-3720; published ahead of print February 25, 2004, doi:10.1073/pnas.0305531101

Biological Sciences

Applied Biological Sciences

  • Physical Sciences - Applied Physical Sciences - Biological Sciences - Applied Biological Sciences:
    • Stephan Thiberge,
    • Amotz Nechushtan,
    • David Sprinzak,
    • Opher Gileadi,
    • Vered Behar,
    • Ory Zik,
    • Yehuda Chowers,
    • Shulamit Michaeli,
    • Joseph Schlessinger,
    • and Elisha Moses

    Scanning electron microscopy of cells and tissues under fully hydrated conditions

    PNAS 2004 101:3346-3351; published ahead of print February 26, 2004, doi:10.1073/pnas.0400088101

Biochemistry

  • Biological Sciences - Biochemistry:
    • Masao Fujinaga,
    • Maia M. Cherney,
    • Hiroshi Oyama,
    • Kohei Oda,
    • and Michael N. G. James

    The molecular structure and catalytic mechanism of a novel carboxyl peptidase from Scytalidium lignicolum

    PNAS 2004 101:3364-3369; published ahead of print March 1, 2004, doi:10.1073/pnas.0400246101
  • Biological Sciences - Biochemistry:
    • Magnus Hallberg,
    • Gennady V. Polozkov,
    • Guo-Zhen Hu,
    • Jenny Beve,
    • Claes M. Gustafsson,
    • Hans Ronne,
    • and Stefan Björklund

    Site-specific Srb10-dependent phosphorylation of the yeast Mediator subunit Med2 regulates gene expression from the 2-μm plasmid

    PNAS 2004 101:3370-3375; published ahead of print February 26, 2004, doi:10.1073/pnas.0400221101
  • Biological Sciences - Biochemistry:
    • Fabienne Paumet,
    • Vahid Rahimian,
    • and James E. Rothman

    The specificity of SNARE-dependent fusion is encoded in the SNARE motif

    PNAS 2004 101:3376-3380; published ahead of print February 23, 2004, doi:10.1073/pnas.0400271101
  • Biological Sciences - Biochemistry:
    • Jung H. Suh,
    • Swapna V. Shenvi,
    • Brian M. Dixon,
    • Honglei Liu,
    • Anil K. Jaiswal,
    • Rui-Ming Liu,
    • and Tory M. Hagen

    Decline in transcriptional activity of Nrf2 causes age-related loss of glutathione synthesis, which is reversible with lipoic acid

    PNAS 2004 101:3381-3386; published ahead of print February 25, 2004, doi:10.1073/pnas.0400282101
  • Physical Sciences - Chemistry - Biological Sciences - Biochemistry:
    • Lei Zheng,
    • Ulrich Baumann,
    • and Jean-Louis Reymond

    Molecular mechanism of enantioselective proton transfer to carbon in catalytic antibody 14D9

    PNAS 2004 101:3387-3392; published ahead of print February 26, 2004, doi:10.1073/pnas.0400263101
  • Biological Sciences - Biochemistry:
    • Irwin A. Rose
    • and Todd M. Weaver

    The role of the allosteric B site in the fumarase reaction

    PNAS 2004 101:3393-3397; published ahead of print February 27, 2004, doi:10.1073/pnas.0307524101
  • Biological Sciences - Biochemistry:
    • Shuang Deng,
    • Richard A. Stein,
    • and N. Patrick Higgins

    Transcription-induced barriers to supercoil diffusion in the Salmonella typhimurium chromosome

    PNAS 2004 101:3398-3403; published ahead of print March 1, 2004, doi:10.1073/pnas.0307550101
  • Biological Sciences - Biochemistry:
    • John F. Cipollo,
    • Antoine Awad,
    • Catherine E. Costello,
    • Phillips W. Robbins,
    • and Carlos B. Hirschberg

    Biosynthesis in vitro of Caenorhabditis elegans phosphorylcholine oligosaccharides

    PNAS 2004 101:3404-3408; published ahead of print March 1, 2004, doi:10.1073/pnas.0400384101

Biophysics

  • Biological Sciences - Biophysics:
    • Judith Klein-Seetharaman,
    • Naveena V. K. Yanamala,
    • Fathima Javeed,
    • Philip J. Reeves,
    • Elena V. Getmanova,
    • Michele C. Loewen,
    • Harald Schwalbe,
    • and H. Gobind Khorana

    Differential dynamics in the G protein-coupled receptor rhodopsin revealed by solution NMR

    PNAS 2004 101:3409-3413; published ahead of print February 27, 2004, doi:10.1073/pnas.0308713101
  • Biological Sciences - Biophysics:
    • Lixin Ma,
    • Christopher T. Jones,
    • Teresa D. Groesch,
    • Richard J. Kuhn,
    • and Carol Beth Post

    Solution structure of dengue virus capsid protein reveals another fold

    PNAS 2004 101:3414-3419; published ahead of print March 1, 2004, doi:10.1073/pnas.0305892101
  • Biological Sciences - Biophysics:
    • Fumimasa Nomura,
    • Takehiko Inaba,
    • Satoshi Ishikawa,
    • Miki Nagata,
    • Sho Takahashi,
    • Hirokazu Hotani,
    • and Kingo Takiguchi

    Microscopic observations reveal that fusogenic peptides induce liposome shrinkage prior to membrane fusion

    PNAS 2004 101:3420-3425; published ahead of print February 26, 2004, doi:10.1073/pnas.0304660101
  • Biological Sciences - Biophysics:
    • Neil P. Johnson,
    • Walter A. Baase,
    • and Peter H. von Hippel

    Low-energy circular dichroism of 2-aminopurine dinucleotide as a probe of local conformation of DNA and RNA

    PNAS 2004 101:3426-3431; published ahead of print March 1, 2004, doi:10.1073/pnas.0400591101
  • Biological Sciences - Biophysics:
    • John Karanicolas
    • and Charles L. Brooks, III

    Integrating folding kinetics and protein function: Biphasic kinetics and dual binding specificity in a WW domain

    PNAS 2004 101:3432-3437; published ahead of print February 23, 2004, doi:10.1073/pnas.0304825101

Cell Biology

  • Biological Sciences - Cell Biology:
    • Reuben J. Shaw,
    • Monica Kosmatka,
    • Nabeel Bardeesy,
    • Rebecca L. Hurley,
    • Lee A. Witters,
    • Ronald A. DePinho,
    • and Lewis C. Cantley

    Inaugural Article: The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress

    PNAS 2004 101:3329-3335; published ahead of print February 25, 2004, doi:10.1073/pnas.0308061100
    • See commentary article on page 3327 in issue 10 of volume 101
  • Biological Sciences - Cell Biology:
    • Kenna R. Mills,
    • Mauricio Reginato,
    • Jayanta Debnath,
    • Bridget Queenan,
    • and Joan S. Brugge

    Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is required for induction of autophagy during lumen formation in vitro

    PNAS 2004 101:3438-3443; published ahead of print March 1, 2004, doi:10.1073/pnas.0400443101
  • Biological Sciences - Cell Biology:
    • Lisa M. Klumpp,
    • Andreas Hoenger,
    • and Susan P. Gilbert

    Kinesin's second step

    PNAS 2004 101:3444-3449; published ahead of print February 25, 2004, doi:10.1073/pnas.0307691101
  • Biological Sciences - Cell Biology:
    • Eric J. Smart,
    • Robert A. De Rose,
    • and Steven A. Farber

    Annexin 2–caveolin 1 complex is a target of ezetimibe and regulates intestinal cholesterol transport

    PNAS 2004 101:3450-3455; published ahead of print February 25, 2004, doi:10.1073/pnas.0400441101
  • Biological Sciences - Cell Biology:
    • Qihong Huang,
    • Angel Raya,
    • Paul DeJesus,
    • Sheng-Hao Chao,
    • Kim C. Quon,
    • Jeremy S. Caldwell,
    • Sumit K. Chanda,
    • Juan C. Izpisua-Belmonte,
    • and Peter G. Schultz

    Identification of p53 regulators by genome-wide functional analysis

    PNAS 2004 101:3456-3461; published ahead of print February 27, 2004, doi:10.1073/pnas.0308562100
  • Biological Sciences - Cell Biology:
    • Motohiro Homma,
    • Daisuke Shiomi,
    • Michio Homma,
    • and Ikuro Kawagishi

    Attractant binding alters arrangement of chemoreceptor dimers within its cluster at a cell pole

    PNAS 2004 101:3462-3467; published ahead of print March 1, 2004, doi:10.1073/pnas.0306660101
  • Biological Sciences - Cell Biology:
    • Amandine Vanhoutteghem
    • and Philippe Djian

    Basonuclin 2: An extremely conserved homolog of the zinc finger protein basonuclin

    PNAS 2004 101:3468-3473; published ahead of print February 26, 2004, doi:10.1073/pnas.0400268101

Developmental Biology

  • Biological Sciences - Developmental Biology:
    • Michael T. Tetzlaff,
    • Wei Yu,
    • Mamie Li,
    • Pumin Zhang,
    • Milton Finegold,
    • Kathleen Mahon,
    • J. Wade Harper,
    • Robert J. Schwartz,
    • and Stephen J. Elledge

    Inaugural Article: From the Cover: Defective cardiovascular development and elevated cyclin E and Notch proteins in mice lacking the Fbw7 F-box protein

    PNAS 2004 101:3338-3345; published ahead of print February 6, 2004, doi:10.1073/pnas.0307875101
    • See commentary article on page 3336 in issue 10 of volume 101
  • Biological Sciences - Developmental Biology:
    • Lily Ng,
    • Richard J. Goodyear,
    • Chad A. Woods,
    • Mark J. Schneider,
    • Edward Diamond,
    • Guy P. Richardson,
    • Matthew W. Kelley,
    • Donald L. St. Germain,
    • Valerie Anne Galton,
    • and Douglas Forrest

    Hearing loss and retarded cochlear development in mice lacking type 2 iodothyronine deiodinase

    PNAS 2004 101:3474-3479; published ahead of print March 1, 2004, doi:10.1073/pnas.0307402101

Evolution

  • Biological Sciences - Evolution:
    • Swaine L. Chen,
    • William Lee,
    • Alison K. Hottes,
    • Lucy Shapiro,
    • and Harley H. McAdams

    Codon usage between genomes is constrained by genome-wide mutational processes

    PNAS 2004 101:3480-3485; published ahead of print February 27, 2004, doi:10.1073/pnas.0307827100
  • Biological Sciences - Evolution:
    • Joel D. Parker,
    • Karen M. Parker,
    • Barbara H. Sohal,
    • Rajindar S. Sohal,
    • and Laurent Keller

    Decreased expression of Cu–Zn superoxide dismutase 1 in ants with extreme lifespan

    PNAS 2004 101:3486-3489; published ahead of print March 1, 2004, doi:10.1073/pnas.0400222101
  • Biological Sciences - Evolution:
    • Andres Aguilar,
    • Gary Roemer,
    • Sally Debenham,
    • Matthew Binns,
    • David Garcelon,
    • and Robert K. Wayne

    High MHC diversity maintained by balancing selection in an otherwise genetically monomorphic mammal

    PNAS 2004 101:3490-3494; published ahead of print February 27, 2004, doi:10.1073/pnas.0306582101
  • Biological Sciences - Evolution:
    • Yang Liu,
    • Mark Gerstein,
    • and Donald M. Engelman

    Transmembrane protein domains rarely use covalent domain recombination as an evolutionary mechanism

    PNAS 2004 101:3495-3497; published ahead of print March 1, 2004, doi:10.1073/pnas.0307330101

Genetics

  • Biological Sciences - Genetics:
    • The U.S.–Venezuela Collaborative Research Project
    • and Nancy S. Wexler

    Venezuelan kindreds reveal that genetic and environmental factors modulate Huntington's disease age of onset

    PNAS 2004 101:3498-3503; published ahead of print March 1, 2004, doi:10.1073/pnas.0308679101
  • Biological Sciences - Genetics:
    • Timothy W. Hefferon,
    • Joshua D. Groman,
    • Catherine E. Yurk,
    • and Garry R. Cutting

    A variable dinucleotide repeat in the CFTR gene contributes to phenotype diversity by forming RNA secondary structures that alter splicing

    PNAS 2004 101:3504-3509; published ahead of print March 1, 2004, doi:10.1073/pnas.0400182101
  • Biological Sciences - Genetics:
    • Giusy Fiucci,
    • Séverine Beaucourt,
    • Dominique Duflaut,
    • Alexandra Lespagnol,
    • Pamela Stumptner-Cuvelette,
    • Anne Géant,
    • Gilles Buchwalter,
    • Marcel Tuynder,
    • Laurent Susini,
    • Jean-Michel Lassalle,
    • Christine Wasylyk,
    • Bohdan Wasylyk,
    • Moshe Oren,
    • Robert Amson,
    • and Adam Telerman

    Siah-1b is a direct transcriptional target of p53: Identification of the functional p53 responsive element in the siah-1b promoter

    PNAS 2004 101:3510-3515; published ahead of print February 25, 2004, doi:10.1073/pnas.0400177101

Immunology

  • Biological Sciences - Immunology:
    • Koichi Tabeta,
    • Philippe Georgel,
    • Edith Janssen,
    • Xin Du,
    • Kasper Hoebe,
    • Karine Crozat,
    • Suzanne Mudd,
    • Louis Shamel,
    • Sosathya Sovath,
    • Jason Goode,
    • Lena Alexopoulou,
    • Richard A. Flavell,
    • and Bruce Beutler

    Toll-like receptors 9 and 3 as essential components of innate immune defense against mouse cytomegalovirus infection

    PNAS 2004 101:3516-3521; published ahead of print March 1, 2004, doi:10.1073/pnas.0400525101
  • Biological Sciences - Immunology:
    • Cecilia Garlanda,
    • Federica Riva,
    • Nadia Polentarutti,
    • Chiara Buracchi,
    • Marina Sironi,
    • Maida De Bortoli,
    • Marta Muzio,
    • Raffaella Bergottini,
    • Eugenio Scanziani,
    • Annunciata Vecchi,
    • Emilio Hirsch,
    • and Alberto Mantovani

    Intestinal inflammation in mice deficient in Tir8 , an inhibitory member of the IL-1 receptor family

    PNAS 2004 101:3522-3526; published ahead of print March 1, 2004, doi:10.1073/pnas.0308680101
  • Biological Sciences - Immunology:
    • James R. Carlyle,
    • Amanda M. Jamieson,
    • Stephan Gasser,
    • Christopher S. Clingan,
    • Hisashi Arase,
    • and David H. Raulet

    Missing self-recognition of Ocil/Clr-b by inhibitory NKR-P1 natural killer cell receptors

    PNAS 2004 101:3527-3532; published ahead of print