Table of Contents

• Les P. Miranda
• and Paul F. Alewood

Accelerated chemical synthesis of peptides and small proteins

• Torsten Fiebig,
• Chaozhi Wan,
• Shana O. Kelley,
• Jacqueline K. Barton,
• and Ahmed H. Zewail

Femtosecond dynamics of the DNA intercalator ethidium and electron transfer with mononucleotides in water

• Evagelos Zacharis,
• Peter J. Halling,
• and D. Gareth Rees

Volatile buffers can override the “pH memory” of subtilisin catalysis in organic media

• David DeGusta,
• W. Henry Gilbert,
• and Scott P. Turner

Hypoglossal canal size and hominid speech

• Robert G. Franciscus

Neandertal nasal structures and upper respiratory tract “specialization”

• Evagelos Zacharis,
• Peter J. Halling,
• and D. Gareth Rees

Volatile buffers can override the “pH memory” of subtilisin catalysis in organic media

• Eugene V. Ryabov,
• David J. Robinson,
• and Michael E. Taliansky

A plant virus-encoded protein facilitates long-distance movement of heterologous viral RNA

• Patricia Mayville,
• Guangyong Ji,
• Ronald Beavis,
• Hongmei Yang,
• Michael Goger,
• Richard P. Novick,
• and Tom W. Muir

Structure-activity analysis of synthetic autoinducing thiolactone peptides from Staphylococcus aureus responsible for virulence

• Constanze Reinhard,
• Cordula Harter,
• Martina Bremser,
• Britta Brügger,
• Kai Sohn,
• J. Bernd Helms,
• and Felix Wieland

Receptor-induced polymerization of coatomer

• Thomas M. Kristie,
• Jodi L. Vogel,
• and Amy E. Sears

Nuclear localization of the C1 factor (host cell factor) in sensory neurons correlates with reactivation of herpes simplex virus from latency

• Nobuo Tsukamoto,
• Norihiko Kobayashi,
• Sakura Azuma,
• Tadashi Yamamoto,
• and Jun-ichiro Inoue

Two differently regulated nuclear factor κB activation pathways triggered by the cytoplasmic tail of CD40

• Tina Izard,
• Arnthor Ævarsson,
• Mark D. Allen,
• Adrie H. Westphal,
• Richard N. Perham,
• Aart de Kok,
• and Wim G. J. Hol

Principles of quasi-equivalence and Euclidean geometry govern the assembly of cubic and dodecahedral cores of pyruvate dehydrogenase complexes

• Ingrid Struman,
• Frauke Bentzien,
• Hsinyu Lee,
• Véronique Mainfroid,
• Gisela D’Angelo,
• Vincent Goffin,
• Richard I. Weiner,
• and Joseph A. Martial

Opposing actions of intact and N-terminal fragments of the human prolactin/growth hormone family members on angiogenesis: An efficient mechanism for the regulation of angiogenesis

• Howard Y. Chang,
• Xiaolu Yang,
• and David Baltimore

Dissecting Fas signaling with an altered-specificity death-domain mutant: Requirement of FADD binding for apoptosis but not Jun N-terminal kinase activation

• Yu Wai Chen,
• Kelvin Stott,
• and Max F. Perutz

Crystal structure of a dimeric chymotrypsin inhibitor 2 mutant containing an inserted glutamine repeat

• Tatyana Knubovets,
• John J. Osterhout,
• Peter J. Connolly,
• and Alexander M. Klibanov

Structure, thermostability, and conformational flexibility of hen egg-white lysozyme dissolved in glycerol

• Kazumitsu Ueda,
• Jun Komine,
• Michinori Matsuo,
• Susumu Seino,
• and Teruo Amachi

Cooperative binding of ATP and MgADP in the sulfonylurea receptor is modulated by glibenclamide

• Vijay S. Pande
• and Daniel S. Rokhsar

Folding pathway of a lattice model for proteins

• Yashomati M. Patel
• and M. Daniel Lane

Role of calpain in adipocyte differentiation

• Koh Fujinaga,
• Ran Taube,
• Jörg Wimmer,
• Thomas P. Cujec,
• and B. Matija Peterlin

Interactions between human cyclin T, Tat, and the transactivation response element (TAR) are disrupted by a cysteine to tyrosine substitution found in mouse cyclin T

• Werner Zwerschke,
• Sybille Mazurek,
• Paola Massimi,
• Lawrence Banks,
• Erich Eigenbrodt,
• and Pidder Jansen-Dürr

Modulation of type M₂ pyruvate kinase activity by the human papillomavirus type 16 E7 oncoprotein

• Thomas Scheibel,
• Heiko Ingo Siegmund,
• Rainer Jaenicke,
• Peter Ganz,
• Hauke Lilie,
• and Johannes Buchner

The charged region of Hsp90 modulates the function of the N-terminal domain

• Xiantuo Wu,
• Thomas E. Wilson,
• and Michael R. Lieber

A role for FEN-1 in nonhomologous DNA end joining: The order of strand annealing and nucleolytic processing events

• Duilio Arigoni,
• Wolfgang Eisenreich,
• Christoph Latzel,
• Silvia Sagner,
• Tanja Radykewicz,
• Meinhart H. Zenk,
• and Adelbert Bacher

Dimethylallyl pyrophosphate is not the committed precursor of isopentenyl pyrophosphate during terpenoid biosynthesis from 1-deoxyxylulose in higher plants

• Marco Linari,
• Marius Ueffing,
• Forbes Manson,
• Alan Wright,
• Thomas Meitinger,
• and Jörg Becker

The retinitis pigmentosa GTPase regulator, RPGR, interacts with the delta subunit of rod cyclic GMP phosphodiesterase

• Nabil G. Seidah,
• Seyed J. Mowla,
• Josée Hamelin,
• Aida M. Mamarbachi,
• Suzanne Benjannet,
• Barry B. Touré,
• Ajoy Basak,
• Jon Scott Munzer,
• Jadwiga Marcinkiewicz,
• Mei Zhong,
• Jean-Christophe Barale,
• Claude Lazure,
• Richard A. Murphy,
• Michel Chrétien,
• and Mieczyslaw Marcinkiewicz

Mammalian subtilisin/kexin isozyme SKI-1: A widely expressed proprotein convertase with a unique cleavage specificity and cellular localization

• Torsten Exner,
• Ole N. Jensen,
• Matthias Mann,
• Christiane Kleuss,
• and Bernd Nürnberg

Posttranslational modification of Gα_o1 generates Gα_o3, an abundant G protein in brain

• B. Stallmeyer,
• G. Schwarz,
• J. Schulze,
• A. Nerlich,
• J. Reiss,
• J. Kirsch,
• and R. R. Mendel

The neurotransmitter receptor-anchoring protein gephyrin reconstitutes molybdenum cofactor biosynthesis in bacteria, plants, and mammalian cells

• Michael C.-Y. Hu,
• Pedro Tranque,
• Gerald M. Edelman,
• and Vincent P. Mauro

rRNA-complementarity in the 5′ untranslated region of mRNA specifying the Gtx homeodomain protein: Evidence that base- pairing to 18S rRNA affects translational efficiency

• Brent A. Altheim
• and Michael C. Schultz

Histone modification governs the cell cycle regulation of a replication-independent chromatin assembly pathway in Saccharomyces cerevisiae

• André Krammer,
• Hui Lu,
• Barry Isralewitz,
• Klaus Schulten,
• and Viola Vogel

Forced unfolding of the fibronectin type III module reveals a tensile molecular recognition switch

• Hiroshi Yamaguchi,
• James N. Muth,
• Maria Varadi,
• Arnold Schwartz,
• and Gyula Varadi

Critical role of conserved proline residues in the transmembrane segment 4 voltage sensor function and in the gating of L-type calcium channels

• Wolfgang Reuter,
• Georg Wiegand,
• Robert Huber,
• and Manuel E. Than

Structural analysis at 2.2 Å of orthorhombic crystals presents the asymmetry of the allophycocyanin–linker complex, AP⋅L_C^7.8, from phycobilisomes of Mastigocladus laminosus

• Christopher D. Rosin,
• Richard K. Belew,
• Garrett M. Morris,
• Arthur J. Olson,
• and David S. Goodsell

Coevolutionary analysis of resistance-evading peptidomimetic inhibitors of HIV-1 protease

• Thorsten Winkler,
• Ulrich Kettling,
• Andre Koltermann,
• and Manfred Eigen

Confocal fluorescence coincidence analysis: An approach to ultra high-throughput screening

• Esben P. Friis,
• Jens E. T. Andersen,
• Yu. I. Kharkats,
• A. M. Kuznetsov,
• R. J. Nichols,
• J.-D. Zhang,
• and Jens Ulstrup

An approach to long-range electron transfer mechanisms in metalloproteins: In situ scanning tunneling microscopy with submolecular resolution

• Jean-Luc Battini,
• John E. J. Rasko,
• and A. Dusty Miller

A human cell-surface receptor for xenotropic and polytropic murine leukemia viruses: Possible role in G protein-coupled signal transduction

• Jochen Walter,
• Alice Schindzielorz,
• Jürgen Grünberg,
• and Christian Haass

Phosphorylation of presenilin-2 regulates its cleavage by caspases and retards progression of apoptosis

• Xingyong Wu
• and Robert E. Palazzo

Differential regulation of maternal vs. paternal centrosomes

• Akihiro Kurimasa,
• Honghai Ouyang,
• Li-jin Dong,
• Sa Wang,
• Xiaoling Li,
• Carlos Cordon-Cardo,
• David J. Chen,
• and Gloria C. Li

Catalytic subunit of DNA-dependent protein kinase: Impact on lymphocyte development and tumorigenesis

• Debra F. Nathan,
• Melissa Harju Vos,
• and Susan Lindquist

Identification of SSF1, CNS1, and HCH1 as multicopy suppressors of a Saccharomyces cerevisiae Hsp90 loss-of-function mutation

• David A. Tice,
• Jacqueline S. Biscardi,
• Amanda L. Nickles,
• and Sarah J. Parsons

Mechanism of biological synergy between cellular Src and epidermal growth factor receptor

• Ho H. Lee,
• Paul W. Dempsey,
• Thomas P. Parks,
• Xiaoqing Zhu,
• David Baltimore,
• and Genhong Cheng