Table of Contents

Commentaries

Commentary:
- Daniel A. Goodenough
Plugging the leaks
PNAS 1999 96:319-321
- See companion article on page 511 in issue 2 of volume 96
Commentary:
- Denis Duboule
No milk today (my Hox have gone away)
PNAS 1999 96:322-323
- See companion article on page 541 in issue 2 of volume 96
Commentary:
- Gary J. Nabel
Development of optimized vectors for gene therapy
PNAS 1999 96:324-326
- See companion article on page 355 in issue 2 of volume 96
Commentary:
- Paul Schimmel
- and Lluis Ribas de Pouplana
Genetic code origins: Experiments confirm phylogenetic predictions and may explain a puzzle
PNAS 1999 96:327-328
- See companion article on page 418 in issue 2 of volume 96
Commentary:
- Thomas A. Blanpied
- and George J. Augustine
Protein kinase A takes center stage in ATP-dependent insulin secretion
PNAS 1999 96:329-331
- See companion article on page 760 in issue 2 of volume 96
Commentary:
- Hongtao Yu
Extending the size limit of protein nuclear magnetic resonance
PNAS 1999 96:332-334
- See companion article on page 388 in issue 2 of volume 96
Commentary:
- Carlo Sala
- and Morgan Sheng
The fyn art of N-methyl-d-aspartate receptor phosphorylation
PNAS 1999 96:335-337
- See companion article on page 435 in issue 2 of volume 96

Physical Sciences

Chemistry

Select this article
Physical Sciences - Chemistry:
- Jianming Cao,
- Hyotcherl Ihee,
- and Ahmed H. Zewail
Ultrafast electron diffraction and direct observation of transient structures in a chemical reaction
PNAS 1999 96:338-342

Biological Sciences

Biophysics

Select this article
Biological Sciences - Biophysics:
- Sergio Gurrieri,
- Steven B. Smith,
- and Carlos Bustamante
Trapping of megabase-sized DNA molecules during agarose gel electrophoresis
PNAS 1999 96:453-458
Select this article
Biological Sciences - Biophysics:
- Barden Chan,
- Kristin Weidemaier,
- Wai-Tak Yip,
- Paul F. Barbara,
- and Karin Musier-Forsyth
Intra-tRNA distance measurements for nucleocapsid proteindependent tRNA unwinding during priming of HIV reverse transcription
PNAS 1999 96:459-464
Select this article
Biological Sciences - Biophysics:
- Matthew Walker,
- Xue-Zhong Zhang,
- Wei Jiang,
- John Trinick,
- and Howard D. White
Observation of transient disorder during myosin subfragment-1 binding to actin by stopped-flow fluorescence and millisecond time resolution electron cryomicroscopy: Evidence that the start of the crossbridge power stroke in muscle has variable geometry
PNAS 1999 96:465-470
Select this article
Biological Sciences - Biophysics:
- G. Sagvolden,
- I. Giaever,
- E. O. Pettersen,
- and J. Feder
Cell adhesion force microscopy
PNAS 1999 96:471-476
Select this article
Biological Sciences - Biophysics:
- Yawen Bai
Kinetic evidence for an on-pathway intermediate in the folding of cytochrome c
PNAS 1999 96:477-480
Select this article
Biological Sciences - Biophysics:
- Alexander Pertsemlidis,
- Alan K. Soper,
- Jon M. Sorenson,
- and Teresa Head-Gordon
Evidence for microscopic, long-range hydration forces for a hydrophobic amino acid
PNAS 1999 96:481-486
Select this article
Biological Sciences - Biophysics:
- Markus Eilers,
- Philip J. Reeves,
- Weiwen Ying,
- H. Gobind Khorana,
- and Steven O. Smith
Magic angle spinning NMR of the protonated retinylidene Schiff base nitrogen in rhodopsin: Expression of ¹⁵N-lysine- and ¹³C-glycine-labeled opsin in a stable cell line
PNAS 1999 96:487-492

Cell Biology

Select this article
Biological Sciences - Cell Biology:
- Sutapa Mukherjee,
- Krzysztof Palczewski,
- Vsevolod Gurevich,
- Jeffrey L. Benovic,
- J. Paul Banga,
- and Mary Hunzicker-Dunn
A direct role for arrestins in desensitization of the luteinizing hormone/choriogonadotropin receptor in porcine ovarian follicular membranes
PNAS 1999 96:493-498
Select this article
Biological Sciences - Cell Biology:
- Taroh Iiri,
- Sean M. Bell,
- Thomas J. Baranski,
- Toshiro Fujita,
- and Henry R. Bourne
A G_sα mutant designed to inhibit receptor signaling through G_s
PNAS 1999 96:499-504
Select this article
Biological Sciences - Cell Biology:
- Larry Pederson,
- Matthew Kremer,
- Jeffrey Judd,
- David Pascoe,
- Thomas C. Spelsberg,
- B. Lawrence Riggs,
- and Merry Jo Oursler
Androgens regulate bone resorption activity of isolated osteoclasts in vitro
PNAS 1999 96:505-510
Select this article
Biological Sciences - Cell Biology:
- Kazumasa Morita,
- Mikio Furuse,
- Kazushi Fujimoto,
- and Shoichiro Tsukita
Claudin multigene family encoding four-transmembrane domain protein components of tight junction strands
PNAS 1999 96:511-516
- See commentary article on page 319 in issue 2 of volume 96
Select this article
Biological Sciences - Cell Biology:
- Chang-rung Chen,
- Ying-chun Li,
- Jing Chen,
- Ming-chin Hou,
- Piyi Papadaki,
- and Eric C. Chang
Moe1, a conserved protein in Schizosaccharomyces pombe, interacts with a Ras effector, Scd1, to affect proper spindle formation
PNAS 1999 96:517-522

Developmental Biology

Select this article
Biological Sciences - Developmental Biology:
- Urte Gayko,
- Vaughn Cleghon,
- Terry Copeland,
- Deborah K. Morrison,
- and Norbert Perrimon
Synergistic activities of multiple phosphotyrosine residues mediate full signaling from the Drosophila Torso receptor tyrosine kinase
PNAS 1999 96:523-528
Select this article
Biological Sciences - Developmental Biology:
- Elisabeth Verpy,
- Michel Leibovici,
- and Christine Petit
Characterization of otoconin-95, the major protein of murine otoconia, provides insights into the formation of these inner ear biominerals
PNAS 1999 96:529-534
Select this article
Biological Sciences - Developmental Biology:
- Hailan Zhang
- and Michael Levine
Inaugural Article: Groucho and dCtBP mediate separate pathways of transcriptional repression in the Drosophila embryo
PNAS 1999 96:535-540
Select this article
Biological Sciences - Developmental Biology:
- Feng Chen
- and Mario R. Capecchi
Paralogous mouse Hox genes, Hoxa9, Hoxb9, and Hoxd9, function together to control development of the mammary gland in response to pregnancy
PNAS 1999 96:541-546
- See commentary article on page 322 in issue 2 of volume 96
Select this article
Biological Sciences - Developmental Biology:
- Olivia Wendling,
- Pierre Chambon,
- and Manuel Mark
Retinoid X receptors are essential for early mouse development and placentogenesis
PNAS 1999 96:547-551
Select this article
Biological Sciences - Developmental Biology:
- Jianrong Lu,
- Robert Webb,
- James A. Richardson,
- and Eric N. Olson
MyoR: A muscle-restricted basic helix–loop–helix transcription factor that antagonizes the actions of MyoD
PNAS 1999 96:552-557
Select this article
Biological Sciences - Developmental Biology:
- P. Callaerts,
- A. M. Munoz-Marmol,
- S. Glardon,
- E. Castillo,
- H. Sun,
- W.-H. Li,
- W. J. Gehring,
- and E. Salo
Isolation and expression of a Pax-6 gene in the regenerating and intact Planarian Dugesia(G)tigrina
PNAS 1999 96:558-563
Select this article
Biological Sciences - Developmental Biology:
- Bernd Hauck,
- Walter J. Gehring,
- and Uwe Walldorf
Functional analysis of an eye specific enhancer of the eyeless gene in Drosophila
PNAS 1999 96:564-569

Ecology

Select this article
Biological Sciences - Ecology:
- R. G. Nager,
- P. Monaghan,
- R. Griffiths,
- D. C. Houston,
- and R. Dawson
Experimental demonstration that offspring sex ratio varies with maternal condition
PNAS 1999 96:570-573

Evolution

Select this article
Biological Sciences - Evolution:
- James D. Fry,
- Peter D. Keightley,
- Stefanie L. Heinsohn,
- and Sergey V. Nuzhdin
New estimates of the rates and effects of mildly deleterious mutation in Drosophila melanogaster
PNAS 1999 96:574-579
Select this article
Biological Sciences - Evolution:
- Robert P. Hirt,
- John M. Logsdon, Jr.,
- Bryan Healy,
- Michael W. Dorey,
- W. Ford Doolittle,
- and T. Martin Embley
Microsporidia are related to Fungi: Evidence from the largest subunit of RNA polymerase II and other proteins
PNAS 1999 96:580-585

Plugging the leaks

No milk today (my Hox have gone away)

Development of optimized vectors for gene therapy

Genetic code origins: Experiments confirm phylogenetic predictions and may explain a puzzle

Protein kinase A takes center stage in ATP-dependent insulin secretion

Extending the size limit of protein nuclear magnetic resonance

The fyn art of N-methyl-d-aspartate receptor phosphorylation

Ultrafast electron diffraction and direct observation of transient structures in a chemical reaction

Persistence of an alternate chromatin structure at silenced loci in vitro

Tissue-specific and developmental stage-specific DNA binding by a mammalian SWI/SNF complex associated with human fetal-to-adult globin gene switching

Adenovirus-mediated regulable target gene expression in vivo

Silicatein filaments and subunits from a marine sponge direct the polymerization of silica and silicones in vitro

Site-directed hydroxyl radical probing of 30S ribosomal subunits by using Fe(II) tethered to an interruption in the 16S rRNA chain

Antitumor activity of mannan-binding protein in vivo as revealed by a virus expression system: Mannan-binding proteindependent cell-mediated cytotoxicity

The Med1 subunit of the yeast mediator complex is involved in both transcriptional activation and repression

Interaction between cyclin-dependent kinases and human papillomavirus replication-initiation protein E1 is required for efficient viral replication

Chemical ligation of folded recombinant proteins: Segmental isotopic labeling of domains for NMR studies

Myosin I heavy chain kinase: Cloning of the full-length gene and acidic lipid-dependent activation by Rac and Cdc42

Asparagine and glutamine rotamers: B-factor cutoff and correction of amide flips yield distinct clustering

A β-1,3-N-acetylglucosaminyltransferase with poly-N-acetyllactosamine synthase activity is structurally related to β-1,3-galactosyltransferases

Persistent membrane association of activated and depalmitoylated G protein α subunits

Substrate recognition by class I lysyl-tRNA synthetases: A molecular basis for gene displacement

Expression of the p48 xeroderma pigmentosum gene is p53-dependent and is involved in global genomic repair

Involvement of regulatory and catalytic subunits of phosphoinositide 3-kinase in NF-κB activation

PSD-95 promotes Fyn-mediated tyrosine phosphorylation of the N-methyl-d-aspartate receptor subunit NR2A

The Cdc6p nucleotide-binding motif is required for loading Mcm proteins onto chromatin

The enzymological basis for resistance of herpesvirus DNA polymerase mutants to acyclovir: Relationship to the structure of α-like DNA polymerases

Trapping of megabase-sized DNA molecules during agarose gel electrophoresis

Intra-tRNA distance measurements for nucleocapsid proteindependent tRNA unwinding during priming of HIV reverse transcription

Observation of transient disorder during myosin subfragment-1 binding to actin by stopped-flow fluorescence and millisecond time resolution electron cryomicroscopy: Evidence that the start of the crossbridge power stroke in muscle has variable geometry

Cell adhesion force microscopy

Kinetic evidence for an on-pathway intermediate in the folding of cytochrome c

Evidence for microscopic, long-range hydration forces for a hydrophobic amino acid

Magic angle spinning NMR of the protonated retinylidene Schiff base nitrogen in rhodopsin: Expression of 15N-lysine- and 13C-glycine-labeled opsin in a stable cell line

A direct role for arrestins in desensitization of the luteinizing hormone/choriogonadotropin receptor in porcine ovarian follicular membranes

A Gsα mutant designed to inhibit receptor signaling through Gs

Androgens regulate bone resorption activity of isolated osteoclasts in vitro

Claudin multigene family encoding four-transmembrane domain protein components of tight junction strands

Moe1, a conserved protein in Schizosaccharomyces pombe, interacts with a Ras effector, Scd1, to affect proper spindle formation

Synergistic activities of multiple phosphotyrosine residues mediate full signaling from the Drosophila Torso receptor tyrosine kinase

Characterization of otoconin-95, the major protein of murine otoconia, provides insights into the formation of these inner ear biominerals

Inaugural Article: Groucho and dCtBP mediate separate pathways of transcriptional repression in the Drosophila embryo

Paralogous mouse Hox genes, Hoxa9, Hoxb9, and Hoxd9, function together to control development of the mammary gland in response to pregnancy

Retinoid X receptors are essential for early mouse development and placentogenesis

MyoR: A muscle-restricted basic helix–loop–helix transcription factor that antagonizes the actions of MyoD

Isolation and expression of a Pax-6 gene in the regenerating and intact Planarian Dugesia(G)tigrina

Functional analysis of an eye specific enhancer of the eyeless gene in Drosophila

Experimental demonstration that offspring sex ratio varies with maternal condition

New estimates of the rates and effects of mildly deleterious mutation in Drosophila melanogaster

Microsporidia are related to Fungi: Evidence from the largest subunit of RNA polymerase II and other proteins

Magic angle spinning NMR of the protonated retinylidene Schiff base nitrogen in rhodopsin: Expression of ¹⁵N-lysine- and ¹³C-glycine-labeled opsin in a stable cell line

A G_sα mutant designed to inhibit receptor signaling through G_s