Library of libraries: approach to synthetic combinatorial library design and screening of "pharmacophore" motifs
- N F Sepetov,
- V Krchnák,
- M Stanková,
- S Wade,
- K S Lam, and
- M Lebl
Abstract
Construction of synthetic combinatorial libraries is described that allows for the generation of a library of motifs rather than a library of compounds. Peptide libraries based on this strategy were synthesized and screened with model targets streptavidin and anti-beta-endorphin antibody. The screens resulted in observation of expected motifs providing evidence of the effectiveness of the suggested approach.
