Proviruses are adjacent to c-myc in some murine leukemia virus-induced lymphomas

Abstract

Sixty-one murine leukemia virus-induced lymphomas were examined for evidence of proviral insertions adjacent to known oncogenes. Five of these lymphomas were found to have alterations adjacent to c-myc. Two of the lymphomas with altered c-myc sequences were examined in detail. Evidence was obtained showing that the alterations in the c-myc sequences in these two lymphomas were the result of proviral integrations. This result suggests that lymphomagenesis by murine leukemia viruses can result from insertional mutagenesis of cellular oncogenes.