Leukemia Viruses Associated with Mouse Myeloma Cells*
Abstract
Myeloma cells derived from BALB/c and C3H mice show evidence of infection by a murine leumemia virus. The immunoglobulin-producing myelomas secrete an RNA-containing virus with a density of 1.20 to 1.22 gm/cm3. RNA with a sedimentation coefficient of 74 S in 0.1 M sodium sodium chloride has been isolated from secreted virus particles and has a base composition similar to that found for other murine leukemia virus RNA. An intracellular virus particle has been partially purified and has a density of 1.29 to 1.32 gm/cm3. Both extracellular and intracellular virus particles contain the leukemia virus group-specific antigen.
Footnotes
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↵ † Recipient of Public Health Service fellowship 1 FO2 A138301-01.
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↵ ‡ Dernham Senior Fellow (D-127) of the American Cancer Society, California Division.
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↵ * Supported by National Cancer Institute contract PH-43-67-1147 and by American Cancer Society, California Division, grant to S. S., also a National Institute of Allergy and Infectious Diseases research grant and a National Cancer Institute training grant to M. C.
