A Cell-Associated Factor Essential for Formation of an Infectious Form of Rous Sarcoma Virus*

  1. H. Hanafusa,
  2. T. Miyamoto, and
  3. T. Hanafusa
  1. THE PUBLIC HEALTH RESEARCH INSTITUTE OF THE CITY OF NEW YORK, INC.

Abstract

Formation of a specific type of infectious Rous sarcoma virus called RSV(0) has been found to occur only in a certain type of chick embryo cell in the absence of avian leukosis virus. Although these chick cells lack any complete form of avian leukovirus, they appear to carry a genetic factor essential for formation of infectious RSV(0). A factor-deficient cell can be converted to a producer of infectious RSV(0) by infection with Rous sarcoma virus or avian leukosis virus which has been grown in factor-containing cells. Evidence is presented to show that the factor determines both the antigenic and host range specificity of RSV(0).

Footnotes

  • ↵ * This investigation was supported in part by the U.S. Public Health Service research grant CA 08747 from the National Cancer Institute.

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  1. PNAS June 1, 1970 vol. 66 no. 2 314-321
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