CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASES, IV. WIDESPREAD OCCURRENCE OF ADENOSINE 3′,5′-MONOPHOSPHATE-DEPENDENT PROTEIN KINASE IN VARIOUS TISSUES AND PHYLA OF THE ANIMAL KINGDOM

CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASES, IV. WIDESPREAD OCCURRENCE OF ADENOSINE 3′,5′-MONOPHOSPHATE-DEPENDENT PROTEIN KINASE IN VARIOUS TISSUES AND PHYLA OF THE ANIMAL KINGDOM^*

J. F. Kuo and
Paul Greengard

DEPARTMENT OF PHARMACOLOGY, YALE UNIVERSITY SCHOOL OF MEDICINE, NEW HAVEN, CONNECTICUT

Abstract

Adenosine 3′,5′-monophosphate-dependent protein kinase activity was found in about thirty sources including many mammalian tissues as well as species representative of eight different invertebrate phyla. The data support a unifying theory for the mechanism of action of adenosine 3′,5′-monophosphate, namely that its many and diverse effects are mediated through activation of tissue-specific protein kinases.

Footnotes

↵ * Aided by a grant (GB-8391) from the National Science Foundation and a grant (NB-08440) from the USPHS. Papers I, II and III in this series are References 5, 6 and 11, respectively. We thank P. L. Reyes, J. Sanes, and B. Krueger for assistance.