HYPERPYREXIA AND ANTIPYRESIS OWING TO SODIUM ACETYLSALICYLATE IN INTACT AND DECAPITATE CATS*,†

  1. David P. C. Lloyd
  1. THE ROCKEFELLER UNIVERSITY, NEW YORK, N.Y.

Abstract

Sodium acetylsalicylate (100 mg/kg) intravenously injected into anaesthetized intact or decapitate cats caused an increase in body temperature. At a dosage of 30 mg per kilogram it caused a lowering of body temperature in the intact preparations, but again an increase in decapitate preparations. At a dosage of 10 mg per kilogram, no significant temperature change occurred in either type of preparation. Aspirin (in the form of sodium acetylsalicylate) is a systemic pyrogen and a centrally acting antipyretic. When it occurs, aspirin antipyresis must take place in the face of systemic pyrogenesis. Notable is the fact that aspirin (30 mg/kg) in the intact preparation lowers body temperature not only from fever levels, but also from normal and subnormal levels.

Footnotes

  • ↵ * This investigation was supported by U.S. Public Health Service research grant NB02816 from the National Institute of Neurological Diseases and Stroke, USPHS.

  • ↵ † Read before the Academy, April 24, 1968, under the title “Action of Sodium Acetylsalicylate upon Body Temperature of the Cat.”

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  1. PNAS December 1, 1969 vol. 64 no. 4 1165-1171
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