Dachshund inhibits oncogene-induced breast cancer cellular migration and invasion through suppression of interleukin-8

DACH1 inhibits migration and invasion of highly metastatic MDA-MB-231 cells. (A) Phase contrast microscopy of MDA-MB-231 cells induced to express DACH1 (Lower) versus vehicle-treated cells (Upper). (Magnification: Left, 200×; Right, 400×.) (B–D) MDA-MB-231 cells stably expressing ponasterone A inducible DACH1 were assessed for either transwell migration (B), matrigel invasion (C), wound closure (D Left) or velocity-analyzed by videomicroscopy at a single-cell level (D Right), with mean data shown at 360 min. *, P < 0.01.