Cover illustration

February 3, 2004; 101 (5)
Cover image expansion

Cover image: In response to bacterial infection, the host immune system mounts a robust attack to clear the invading pathogen. A leukocyte (blue) attacks uropathogenic Escherichia coli (UPEC; green) on the surface of a mouse bladder epithelium (purple). UPEC employ strategies to evade host inflammatory response, including biofilm formation inside the bladder epithelialcells. See the article by Justice et al. on pages 1333–1338.