Table of Contents

January 27, 2004; 101 (4)

FROM THE COVER

Commentaries

Commentary:
- Jinoh Kim
- and Randy Schekman
The ins and outs of presenilin 1 membrane topology
PNAS 2004 101:905-906; published online before print January 19, 2004, doi:10.1073/pnas.0307297101
- See companion article on page 1057 in issue 4 of volume 101
Commentary:
- Richard W. Ordway
Quantal size fits central synaptic depression
PNAS 2004 101:907-908; published online before print January 19, 2004, doi:10.1073/pnas.0307309101
- See companion article on page 1063 in issue 4 of volume 101

Physical Sciences

Computer Sciences

Select this article
Physical Sciences - Computer Sciences - Biological Sciences - Plant Biology:
- David Peak,
- Jevin D. West,
- Susanna M. Messinger,
- and Keith A. Mott
Evidence for complex, collective dynamics and emergent, distributed computation in plants
PNAS 2004 101:918-922; published online before print January 19, 2004, doi:10.1073/pnas.0307811100

Biological Sciences

Biochemistry

Select this article
Biological Sciences - Biochemistry:
- Dawn Mattoon,
- Peter Klein,
- Mark A. Lemmon,
- Irit Lax,
- and Joseph Schlessinger
The tethered configuration of the EGF receptor extracellular domain exerts only a limited control of receptor function
PNAS 2004 101:923-928; published online before print January 19, 2004, doi:10.1073/pnas.0307286101
Select this article
Biological Sciences - Biochemistry:
- Peter Klein,
- Dawn Mattoon,
- Mark A. Lemmon,
- and Joseph Schlessinger
A structure-based model for ligand binding and dimerization of EGF receptors
PNAS 2004 101:929-934; published online before print January 19, 2004, doi:10.1073/pnas.0307285101
Select this article
Biological Sciences - Biochemistry:
- Shaun K. Olsen,
- Omar A. Ibrahimi,
- Angela Raucci,
- Fuming Zhang,
- Anna V. Eliseenkova,
- Avner Yayon,
- Claudio Basilico,
- Robert J. Linhardt,
- Joseph Schlessinger,
- and Moosa Mohammadi
Insights into the molecular basis for fibroblast growth factor receptor autoinhibition and ligand-binding promiscuity
PNAS 2004 101:935-940; published online before print January 19, 2004, doi:10.1073/pnas.0307287101
Select this article
Biological Sciences - Biochemistry:
- Ana Karin Kusnetzow,
- Abhiram Dukkipati,
- Kunnel R. Babu,
- Lavoisier Ramos,
- Barry E. Knox,
- and Robert R. Birge
Vertebrate ultraviolet visual pigments: Protonation of the retinylidene Schiff base and a counterion switch during photoactivation
PNAS 2004 101:941-946; published online before print January 19, 2004, doi:10.1073/pnas.0305206101
Select this article
Biological Sciences - Biochemistry:
- Marina Cotsiki,
- Rowena L. Lock,
- Yuan Cheng,
- Grace L. Williams,
- Jean Zhao,
- David Perera,
- Raimundo Freire,
- Alan Entwistle,
- Erica A. Golemis,
- Thomas M. Roberts,
- Parmjit S. Jat,
- and Ole V. Gjoerup
Simian virus 40 large T antigen targets the spindle assembly checkpoint protein Bub1
PNAS 2004 101:947-952; published online before print January 19, 2004, doi:10.1073/pnas.0308006100
Select this article
Biological Sciences - Biochemistry:
- Shigeru Ariki,
- Kumiko Koori,
- Tsukasa Osaki,
- Kiyohito Motoyama,
- Kei-ichiro Inamori,
- and Shun-ichiro Kawabata
From the Cover: A serine protease zymogen functions as a pattern-recognition receptor for lipopolysaccharides
PNAS 2004 101:953-958; published online before print January 13, 2004, doi:10.1073/pnas.0306904101

Biophysics

Select this article
Biological Sciences - Biophysics:
- Sarah Yohannan,
- Salem Faham,
- Duan Yang,
- Julian P. Whitelegge,
- and James U. Bowie
The evolution of transmembrane helix kinks and the structural diversity of G protein-coupled receptors
PNAS 2004 101:959-963; published online before print January 19, 2004, doi:10.1073/pnas.0306077101

Cell Biology

Select this article
Biological Sciences - Cell Biology:
- Kristin Walther,
- M. Kasim Diril,
- Nadja Jung,
- and Volker Haucke
Functional dissection of the interactions of stonin 2 with the adaptor complex AP-2 and synaptotagmin
PNAS 2004 101:964-969; published online before print January 15, 2004, doi:10.1073/pnas.0307862100
Select this article
Biological Sciences - Cell Biology:
- Michael E. Ward,
- Jane Y. Wu,
- and Yi Rao
From the Cover: Visualization of spatially and temporally regulated N-WASP activity during cytoskeletal reorganization in living cells
PNAS 2004 101:970-974; published online before print January 19, 2004, doi:10.1073/pnas.0306258101

Evolution

Select this article
Biological Sciences - Evolution:
- Christopher A. Edmonds,
- Anita S. Lillie,
- and L. Luca Cavalli-Sforza
Mutations arising in the wave front of an expanding population
PNAS 2004 101:975-979; published online before print January 19, 2004, doi:10.1073/pnas.0308064100

Genetics

Select this article
Biological Sciences - Genetics:
- Saumen Pal,
- Alan B. Cantor,
- Kirby D. Johnson,
- Tyler B. Moran,
- Meghan E. Boyer,
- Stuart H. Orkin,
- and Emery H. Bresnick
Coregulator-dependent facilitation of chromatin occupancy by GATA-1
PNAS 2004 101:980-985; published online before print January 8, 2004, doi:10.1073/pnas.0307612100
Select this article
Biological Sciences - Genetics:
- Ann G. Matthysse,
- Karine Deschet,
- Melanie Williams,
- Mazz Marry,
- Alan R. White,
- and William C. Smith
A functional cellulose synthase from ascidian epidermis
PNAS 2004 101:986-991; published online before print January 13, 2004, doi:10.1073/pnas.0303623101
Select this article
Biological Sciences - Genetics:
- Gregory E. Crawford,
- Ingeborg E. Holt,
- James C. Mullikin,
- Denise Tai,
- National Institutes of Health Intramural Sequencing Center,
- Eric D. Green,
- Tyra G. Wolfsberg,
- and Francis S. Collins
From the Cover: Identifying gene regulatory elements by genome-wide recovery of DNase hypersensitive sites
PNAS 2004 101:992-997; published online before print January 19, 2004, doi:10.1073/pnas.0307540100

Immunology

Select this article
Biological Sciences - Immunology:
- Mark J. Miller,
- Arsalan S. Hejazi,
- Sindy H. Wei,
- Michael D. Cahalan,
- and Ian Parker
T cell repertoire scanning is promoted by dynamic dendritic cell behavior and random T cell motility in the lymph node
PNAS 2004 101:998-1003; published online before print January 13, 2004, doi:10.1073/pnas.0306407101
Select this article
Biological Sciences - Immunology:
- Brian C. Schaefer,
- John W. Kappler,
- Abraham Kupfer,
- and Philippa Marrack
Complex and dynamic redistribution of NF-κB signaling intermediates in response to T cell receptor stimulation
PNAS 2004 101:1004-1009; published online before print January 14, 2004, doi:10.1073/pnas.0307858100
Select this article
Biological Sciences - Immunology:
- Kazuhiko Kuwahara,
- Satoru Fujimura,
- Yoshimasa Takahashi,
- Naomi Nakagata,
- Toshitada Takemori,
- Shinichi Aizawa,
- and Nobuo Sakaguchi
Germinal center-associated nuclear protein contributes to affinity maturation of B cell antigen receptor in T cell-dependent responses
PNAS 2004 101:1010-1015; published online before print January 8, 2004, doi:10.1073/pnas.0307609100
Select this article
Biological Sciences - Immunology:
- Noriko Toyama-Sorimachi,
- Yusuke Tsujimura,
- Mikako Maruya,
- Atsuko Onoda,
- Toshiyuki Kubota,
- Shigeo Koyasu,
- Kayo Inaba,
- and Hajime Karasuyama
Ly49Q, a member of the Ly49 family that is selectively expressed on myeloid lineage cells and involved in regulation of cytoskeletal architecture
PNAS 2004 101:1016-1021; published online before print January 19, 2004, doi:10.1073/pnas.0305400101
Select this article
Biological Sciences - Immunology:
- Jang-June Park,
- Suk-Jo Kang,
- A. Dharshan De Silva,
- Aleksandar K. Stanic,
- Giulia Casorati,
- David L. Hachey,
- Peter Cresswell,
- and Sebastian Joyce
Lipid–protein interactions: Biosynthetic assembly of CD1 with lipids in the endoplasmic reticulum is evolutionarily conserved
PNAS 2004 101:1022-1026; published online before print January 13, 2004, doi:10.1073/pnas.0307847100
Select this article
Biological Sciences - Immunology:
- Leo D. Wang,
- Jared Lopes,
- A. Byron Cooper,
- May Dang-Lawson,
- Linda Matsuuchi,
- and Marcus R. Clark
Selection of B lymphocytes in the periphery is determined by the functional capacity of the B cell antigen receptor
PNAS 2004 101:1027-1032; published online before print January 13, 2004, doi:10.1073/pnas.0307040101

Medical Sciences

Select this article
Biological Sciences - Medical Sciences:
- Chih-Wen Peng,
- Yong Xue,
- Bo Zhao,
- Eric Johannsen,
- Elliott Kieff,
- and Shizuko Harada
Direct interactions between Epstein–Barr virus leader protein LP and the EBNA2 acidic domain underlie coordinate transcriptional regulation
PNAS 2004 101:1033-1038; published online before print January 19, 2004, doi:10.1073/pnas.0307808100
Select this article
Biological Sciences - Medical Sciences:
- Carsten Schwaenen,
- Michelle Nessling,
- Swen Wessendorf,
- Tatjana Salvi,
- Gunnar Wrobel,
- Bernhard Radlwimmer,
- Hans A. Kestler,
- Christian Haslinger,
- Stephan Stilgenbauer,
- Hartmut Döhner,
- Martin Bentz,
- and Peter Lichter
Automated array-based genomic profiling in chronic lymphocytic leukemia: Development of a clinical tool and discovery of recurrent genomic alterations
PNAS 2004 101:1039-1044; published online before print January 16, 2004, doi:10.1073/pnas.0304717101
Select this article
Biological Sciences - Medical Sciences:
- Yumei Xiong,
- Norimasa Miyamoto,
- Kenji Shibata,
- Mark A. Valasek,
- Toshiyuki Motoike,
- Rafal M. Kedzierski,
- and Masashi Yanagisawa
Short-chain fatty acids stimulate leptin production in adipocytes through the G protein-coupled receptor GPR41
PNAS 2004 101:1045-1050; published online before print January 13, 2004, doi:10.1073/pnas.2637002100

Neuroscience

Select this article
Biological Sciences - Neuroscience:
- Xiao Yu,
- Kai-Lai Duan,
- Chun-Feng Shang,
- Han-Gang Yu,
- and Zhuan Zhou
Calcium influx through hyperpolarization-activated cation channels (I_h channels) contributes to activity-evoked neuronal secretion
PNAS 2004 101:1051-1056; published online before print January 14, 2004, doi:10.1073/pnas.0305167101
Select this article
Biological Sciences - Neuroscience:
- Nazneen N. Dewji,
- Dante Valdez,
- and S. J. Singer
From the Cover: The presenilins turned inside out: Implications for their structures and functions
PNAS 2004 101:1057-1062; published online before print January 19, 2004, doi:10.1073/pnas.0307290101
- See commentary article on page 905 in issue 4 of volume 101
Select this article
Biological Sciences - Neuroscience:
- Gong Chen,
- Nobutoshi C. Harata,
- and Richard W. Tsien
From the Cover: Paired-pulse depression of unitary quantal amplitude at single hippocampal synapses
PNAS 2004 101:1063-1068; published online before print January 13, 2004, doi:10.1073/pnas.0307149101
- See commentary article on page 907 in issue 4 of volume 101
Select this article
Biological Sciences - Neuroscience:
- Joseph W. Lewcock
- and Randall R. Reed
A feedback mechanism regulates monoallelic odorant receptor expression
PNAS 2004 101:1069-1074; published online before print January 19, 2004, doi:10.1073/pnas.0307986100
Select this article
Biological Sciences - Neuroscience:
- Celina V. Zerbinatti,
- David F. Wozniak,
- John Cirrito,
- Judy A. Cam,
- Hiroshi Osaka,
- Kelly R. Bales,
- Min Zhuo,
- Steven M. Paul,
- David M. Holtzman,
- and Guojun Bu
Increased soluble amyloid-β peptide and memory deficits in amyloid model mice overexpressing the low-density lipoprotein receptor-related protein
PNAS 2004 101:1075-1080; published online before print January 19, 2004, doi:10.1073/pnas.0305803101
Select this article
Biological Sciences - Neuroscience:
- Christopher Cherniak,
- Zekeria Mokhtarzada,
- Raul Rodriguez-Esteban,
- and Kelly Changizi
Global optimization of cerebral cortex layout
PNAS 2004 101:1081-1086; published online before print January 13, 2004, doi:10.1073/pnas.0305212101

Pharmacology

Select this article
Biological Sciences - Pharmacology:
- Jinzhe Mao,
- Xueren Wang,
- Fuxue Chen,
- Runping Wang,
- Asheebo Rojas,
- Yun Shi,
- Hailan Piao,
- and Chun Jiang
Molecular basis for the inhibition of G protein-coupled inward rectifier K⁺ channels by protein kinase C
PNAS 2004 101:1087-1092; published online before print January 19, 2004, doi:10.1073/pnas.0304827101

Plant Biology

Biological Sciences - Plant Biology:
- Christen Brownlee
Inaugural Article: Biography of June B. Nasrallah
PNAS 2004 101:909-910; published online before print January 19, 2004, doi:10.1073/pnas.0400056101
- See commentary article on page 911 in issue 4 of volume 101
Select this article
Biological Sciences - Plant Biology:
- Thanat Chookajorn,
- Aardra Kachroo,
- Daniel R. Ripoll,
- Andrew G. Clark,
- and June B. Nasrallah
Inaugural Article: Specificity determinants and diversification of the Brassica self-incompatibility pollen ligand
PNAS 2004 101:911-917; published online before print December 23, 2003, doi:10.1073/pnas.2637116100
- See commentary article on page 909 in issue 4 of volume 101
Select this article
Physical Sciences - Computer Sciences - Biological Sciences - Plant Biology:
- David Peak,
- Jevin D. West,
- Susanna M. Messinger,
- and Keith A. Mott
Evidence for complex, collective dynamics and emergent, distributed computation in plants
PNAS 2004 101:918-922; published online before print January 19, 2004, doi:10.1073/pnas.0307811100
Select this article
Biological Sciences - Plant Biology:
- Meng-Hsuan Han,
- Saiprasad Goud,
- Liang Song,
- and Nina Fedoroff
The Arabidopsis double-stranded RNA-binding protein HYL1 plays a role in microRNA-mediated gene regulation
PNAS 2004 101:1093-1098; published online before print January 13, 2004, doi:10.1073/pnas.0307969100
Select this article
Biological Sciences - Plant Biology:
- Chitose Kami,
- Keiko Mukougawa,
- Takuya Muramoto,
- Akiho Yokota,
- Tomoko Shinomura,
- J. Clark Lagarias,
- and Takayuki Kohchi
Complementation of phytochrome chromophore-deficient Arabidopsis by expression of phycocyanobilin:ferredoxin oxidoreductase
PNAS 2004 101:1099-1104; published online before print January 13, 2004, doi:10.1073/pnas.0307615100

Psychology

Select this article
Biological Sciences - Psychology:
- Tali Kimchi,
- Ariane S. Etienne,
- and Joseph Terkel
A subterranean mammal uses the magnetic compass for path integration
PNAS 2004 101:1105-1109; published online before print January 19, 2004, doi:10.1073/pnas.0307560100

Correction

Correction:
Correction for Martinez-Castilla et al., Adaptive evolution in the Arabidopsis MADS-box gene family inferred from its complete resolved phylogeny, PNAS 2003 100:13407-13412
PNAS 2004 101:1110; published online before print January 7, 2004, doi:10.1073/pnas.0307417100

FROM THE COVER

The ins and outs of presenilin 1 membrane topology

Quantal size fits central synaptic depression

Evidence for complex, collective dynamics and emergent, distributed computation in plants

The tethered configuration of the EGF receptor extracellular domain exerts only a limited control of receptor function

A structure-based model for ligand binding and dimerization of EGF receptors

Insights into the molecular basis for fibroblast growth factor receptor autoinhibition and ligand-binding promiscuity

Vertebrate ultraviolet visual pigments: Protonation of the retinylidene Schiff base and a counterion switch during photoactivation

Simian virus 40 large T antigen targets the spindle assembly checkpoint protein Bub1

From the Cover: A serine protease zymogen functions as a pattern-recognition receptor for lipopolysaccharides

The evolution of transmembrane helix kinks and the structural diversity of G protein-coupled receptors

Functional dissection of the interactions of stonin 2 with the adaptor complex AP-2 and synaptotagmin

From the Cover: Visualization of spatially and temporally regulated N-WASP activity during cytoskeletal reorganization in living cells

Mutations arising in the wave front of an expanding population

Coregulator-dependent facilitation of chromatin occupancy by GATA-1

A functional cellulose synthase from ascidian epidermis

From the Cover: Identifying gene regulatory elements by genome-wide recovery of DNase hypersensitive sites

T cell repertoire scanning is promoted by dynamic dendritic cell behavior and random T cell motility in the lymph node

Complex and dynamic redistribution of NF-κB signaling intermediates in response to T cell receptor stimulation

Germinal center-associated nuclear protein contributes to affinity maturation of B cell antigen receptor in T cell-dependent responses

Ly49Q, a member of the Ly49 family that is selectively expressed on myeloid lineage cells and involved in regulation of cytoskeletal architecture

Lipid–protein interactions: Biosynthetic assembly of CD1 with lipids in the endoplasmic reticulum is evolutionarily conserved

Selection of B lymphocytes in the periphery is determined by the functional capacity of the B cell antigen receptor

Direct interactions between Epstein–Barr virus leader protein LP and the EBNA2 acidic domain underlie coordinate transcriptional regulation

Automated array-based genomic profiling in chronic lymphocytic leukemia: Development of a clinical tool and discovery of recurrent genomic alterations

Short-chain fatty acids stimulate leptin production in adipocytes through the G protein-coupled receptor GPR41

Calcium influx through hyperpolarization-activated cation channels (Ih channels) contributes to activity-evoked neuronal secretion

From the Cover: The presenilins turned inside out: Implications for their structures and functions

From the Cover: Paired-pulse depression of unitary quantal amplitude at single hippocampal synapses

A feedback mechanism regulates monoallelic odorant receptor expression

Increased soluble amyloid-β peptide and memory deficits in amyloid model mice overexpressing the low-density lipoprotein receptor-related protein

Global optimization of cerebral cortex layout

Molecular basis for the inhibition of G protein-coupled inward rectifier K+ channels by protein kinase C

Inaugural Article: Biography of June B. Nasrallah

Inaugural Article: Specificity determinants and diversification of the Brassica self-incompatibility pollen ligand

Evidence for complex, collective dynamics and emergent, distributed computation in plants

The Arabidopsis double-stranded RNA-binding protein HYL1 plays a role in microRNA-mediated gene regulation

Complementation of phytochrome chromophore-deficient Arabidopsis by expression of phycocyanobilin:ferredoxin oxidoreductase

A subterranean mammal uses the magnetic compass for path integration

Correction for Martinez-Castilla et al., Adaptive evolution in the Arabidopsis MADS-box gene family inferred from its complete resolved phylogeny, PNAS 2003 100:13407-13412

This Issue

Calcium influx through hyperpolarization-activated cation channels (I_h channels) contributes to activity-evoked neuronal secretion

Molecular basis for the inhibition of G protein-coupled inward rectifier K⁺ channels by protein kinase C