Little evidence of bone marrow-derived hepatocytes in the replacement of injured liver

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   Fig. 1.

   (A) GFP-positive nonhepatocytes observed in a liver section from CCl₄-treated mouse. Bromo-4-chloro-3-indolyl β-d-galactoside (X-gal) staining of the whole liver from TgN(MtnLacZ) as a positive control (B) and B6 transplanted with TgN(MtnLacZ) BM mononuclear cells and administered CCl₄ (C). No X-gal positive nodule was observed in the B6 liver. (D) Y chromosome-positive hepatocyte nucleus (arrow) from a mouse in CCl₄ liver injury model. (Scale bars: 50 μm, A; 30 μm, D.)