Sterol-regulated transport of SREBPs from endoplasmic reticulum to Golgi: Insig renders sorting signal in Scap inaccessible to COPII proteins
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Fig. 6.
Differential mechanisms by which cholesterol and oxysterols trigger Insig binding to Scap, which in turn abrogates COPII binding to the MELADL sorting signal in Scap, inhibiting the ER-to-Golgi transport of SREBPs.
This Article
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PNAS April 17, 2007 vol. 104 no. 16 6519-6526
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