Myeloperoxidase up-regulates the catalytic activity of inducible nitric oxide synthase by preventing nitric oxide feedback inhibition

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Fig. 5.
Fig. 5.

Model showing the influence of the MPO/H2O2 system on the formation of the iNOS–nitrosyl complex during steady-state catalysis. Formation of the iNOS–nitrosyl complex is associated with the release of NO from iNOS unless the MPO/H2O2 system is present.


This Article

  1. Published online before print December 1, 2003, doi: 10.1073/pnas.2435008100 PNAS December 9, 2003 vol. 100 no. 25 14766-14771
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